CYCLOTRON AND RADIOCHEMISTRY SPECIALIZED RESOURCE

回旋加速器和放射化学专业资源

基本信息

批准号：
7918209
负责人：
NAGICHETTIAR SATYAMURTHY
金额：
$ 4.88万
依托单位：
CALIFORNIA INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7918209
关键词：
Accidents Accountability Acetonitriles Acids Affinity Air Antibodies Area Award Binding Biodistribution Biological Biological Markers Biological Sciences Biology Bypass Calibration California Camptothecin Cancer Center Carbonates Cell surface Chemicals Chemistry Collaborations Committee Members Communities Computers Construction Materials Cyclodextrins Cyclotrons Data Data Analyses Data Collection Decontamination Deoxyglucose Department of Energy Detection Development Devices Disease Doctor of Philosophy Dose Dose-Rate Duct (organ) structure Employee Strikes Ensure Environmental air flow Equipment Equipment and supply inventories Ethanol Extravasation Fluoride Ion Fluorine Funding Goals Grant Guidelines High Pressure Liquid Chromatography Housing Human Resources Hydrolysis Image Individual Injection of therapeutic agent Institutes Ion-Exchange Chromatography Procedure Ions Isotopes Joints Label Laboratories Laboratory Personnel Laws Left Link Liquid substance Literature Location Maintenance Malignant Neoplasms Mannose Manuals Measurement Measures Membrane Methods Microfluidics Molecular Molecular Medicine Molecular Probes Monitor Mus Names Nature Neurology Neutrons Nuclear Operative Surgical Procedures Output Oxygen Particulate Pharmaceutical Preparations Polymers Positioning Attribute Positron Positron-Emission Tomography Potassium Preparation Procedures Process Product Labeling Production Protocols documentation Protons Pyrogens Quality Control Radiation Radiation Monitoring Radiation Protection Radioactive Radioactivity Radiochemistry Radioisotopes Radiolabeled Radiologic Health Radiopharmaceuticals Reaction Reading Records Refuse Disposal Regulation Research Research Personnel Research Support Resistance Resolution Resources Rest Rewards Safety Scintillation Counter Services Solvents Source Spottings Sterility Sturnus vulgaris Support System Surface Surveys System Tantalum Techniques Technology Testing Thymidine Time Toxic effect Tracer Training Tube Universities Validation Water Work air monitoring alovudine analog aqueous base chemical reaction cost design detector elastomeric exhaust imaging probe in vivo Cellular and Molecular Imaging Centers instrument instrumentation irradiation macromolecule meetings meter methyl iodide molecular imaging mouse model nanoparticle nanosystems oncology prevent programs radiochemical radiotracer repaired research study response small molecule water flow

项目摘要

C1.1.1. Introduction: The CRSR is a Core component of the NSBCC, the NCI UCLA-ICMIC, UCLA Institute for Molecular Medicine (IMED) and Crump Institute for Molecular Imaging. The prime objective of the CRSR is to provide positron emitting radioisotopes and radiolabeled PET probes and biomarkers for investigators in NSBCC, ICMIC, IMED and the Crump Institute. The core is directed by Dr. Satyamuthy. The CRSR was established in 1971 by the Department of Energy as a part of IMED. It currently houses two RDS -112 negative ion cyclotron (CTI, Knoxville, TN) systems that are supported with a wide array of target systems, semiautomated and automated systems producing various radiolabeled precursors for synthesizing molecular probes and biomarkers, and for producing final labeled products as discussed below in detail. The CRSR has more than enough capacity to meet the needs of NSBCC. It has been both scientifically profitable and personally rewarding for the CRSR staff to expand our interactions with the physical and biological sciences community at UCLA. With the NSBCC program, that extension will now include Caltech and ISB researchers. In fact, for some of the NSBCC Projects preliminary results were obtained through joint Caltech/UCLA collaborations. Approximately 10% of our radiosynthesis work over the initial NSBCC funding period will be NSCBB-related, with about 50% of the rest of the work supported by various other NCI supported research and educational programs as discussed in the proposal. In reality, the DoE support supplements, to some extent, programs that are under the aegis of the NSBCC.

C1.1.1。简介：CRSR 是 NSBCC、NCI UCLA-ICMIC、UCLA 研究所的核心组成部分分子医学 (IMED) 和克伦普分子成像研究所。 CRSR 的主要目标是为研究人员提供正电子发射放射性同位素、放射性标记 PET 探针和生物标记物 NSBCC、ICMIC、IMED 和克伦普研究所。核心由 Satyamuthy 博士指导。 CRSR 于 1971 年由能源部成立，是 IMED 的一部分。目前拥有两栋 RDS -112 负离子回旋加速器（CTI，诺克斯维尔，田纳西州）系统，支持多种目标生产各种放射性标记前体用于合成的系统、半自动和自动化系统分子探针和生物标志物，以及用于生产最终标记的产品，如下文详细讨论的。这 CRSR的能力足以满足NSBCC的需求。对于 CRSR 员工来说，扩大我们的互动不仅在科学上有利可图，而且个人也得到了回报与加州大学洛杉矶分校的物理和生物科学界合作。通过 NSBCC 计划，该延期将现在包括加州理工学院和 ISB 的研究人员。事实上，NSBCC 的一些项目的初步结果是通过加州理工学院/加州大学洛杉矶分校联合合作获得。我们的大约 10% 放射合成工作 NSBCC 初始资助期将与 NSCBB 相关，大约其余工作的50% 得到其他各种 NCI 的支持支持的研究和教育计划如提案中进行了讨论。在现实，能源部的支持某种程度的补充，下的计划 NSBCC 的支持。