New Investigation Initiatives for the Prevention of Complications of Thalassemia

预防地中海贫血并发症的新研究举措

• 批准号: 7682881
• 负责人: ALEXIS A THOMPSON
• 金额: $ 20万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2012-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7682881
• 关键词: New; Investigation; Initiatives; Prevention; Complications

Project Abstract The Comprehensive Thalassemia Program of the Children's Memorial Hospital (CMH) is committed to providing state-ofthe-art medical service services using a multidisciplinary approach, including ongoing hemo-vigilance activities. Patients with thalassemia are a vulnerable population who comprise the single largest group of red cell transfusion users at Children's Memorial Hospital and other major U.S. thalassemia treatment centers. As such, they remain at high risk from both known and potential blood-borne pathogens and other complications related to transfusion therapy. This application will delineate expected contributions of CMH to ongoing initiatives by the CDC on blood safety in thalassemia and will describe current and proposed activities to enhance medical services and facilitate research in the prevention and improved management of disease- and/or transfusion-related complications. As the largest thalassemia treatment center in the Midwestern United States, the Comprehensive Thalassemia Program of the Children's Memorial Hospital is uniquely positioned to provide expertise over a wide geographic area to an increasingly diverse ethnic and cultural population affected by this condition. Relevance Red cell transfusions are a cornerstone for the management of thalassemia, a serious inherited blood disorder. Activities directed at improvements in blood safety monitoring have broad implication on the health of the general public. Projects proposed in this application are aimed at improvements in surveillance for blood borne infections, iron overload and other transfusion-related complications.

项目摘要 儿童纪念医院 (CMH) 综合地中海贫血项目 致力于通过先进的技术提供最先进的医疗服务 多学科方法，包括持续的血液警戒活动。患者患有 地中海贫血症是一个弱势群体，由最大的红色群体组成 儿童纪念医院和美国其他主要地中海贫血医院的细胞输血使用者 治疗中心。因此，他们仍然面临已知和潜在的高风险 血源性病原体和其他与输血治疗相关的并发症。这 申请将描述 CMH 对正在进行的举措的预期贡献 疾病预防控制中心关于地中海贫血的血液安全性，并将描述当前和拟议的活动 加强医疗服务并促进预防和改进方面的研究 疾病和/或输血相关并发症的管理。作为最大的 美国中西部地中海贫血综合治疗中心 儿童纪念医院的地中海贫血项目具有独特的优势 为日益多样化的种族和群体提供广泛地理区域的专业知识 受这种情况影响的文化人口。关联 红细胞输注是治疗地中海贫血的基石，地中海贫血是一种严重的疾病 遗传性血液疾病。旨在改进血液安全监测的活动 对广大群众的健康有着广泛的影响。本报告中提出的项目 应用旨在改善血源性感染、铁 超负荷和其他输血相关的并发症。