Supplement to R01 NS124477

R01 NS124477 的补充

• 批准号: 10719354
• 负责人: MICHAEL Ilya BUKRINSKY
• 金额: $ 3.42万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10719354
• 关键词: Administrative Supplement; Affect; Bone Marrow; Brain; Cells; Country; Development; Distress; Exposure to; Funding; Future; Grant; HIV; HIV-1; Hand; Immune; Immunity; Immunology; Investigation; Myeloid Cells; National Institute of Neurological Disorders and Stroke; Neurobiology; Neuroglia; Pathogenesis; Pathogenicity; Play; Politics; Positioning Attribute; Postdoctoral Fellow; Recording of previous events; Research; Role; Scientist; Time; Training; Ukraine; War; antiviral drug development; brain cell; career; experience; extracellular vesicles; imprint; nef Protein; nervous system disorder; neuroinflammation; novel; parent grant; peripheral blood; programs; virology

Abstract We request an Administrative Supplement to our NINDS-funded grant R01 NS124477 ‘Novel pathogenic mechanism of HIV-associated CNS neurological disorders’ to fund a postdoctoral position for a Ukrainian scientist, Dr. Daria Starosyla. She will take over a new research direction in the project funded by the parent grant, investigation of the role that trained immunity plays in the neuroinflammation underlying pathogenesis of HAND. Our recent discoveries suggested a possibility that neuroinflammation is ‘imprinted’ in brain myeloid and glial cells by exposure to extracellular vesicles carrying HIV-1 protein Nef. So far, we have demonstrated this effect in peripheral blood and bone marrow myeloid cells, and the foray into the brain cells will be a novel development in neurobiology and contribute significantly to all Specific Aims of the parent grant. Given Dr. Starosyla’s experience in immunology, virology and development of anti-viral treatments, we believe she is well fit to take over the leading role on this part of the project. In addition to scientific reasons behind this request for Supplemental Funding, it also carries a humanitarian and political significance. The ongoing war in Ukraine severely affects all scientific enterprises in the country and endangers not only the present, but also the future scientific progress in Ukraine. It is critical to provide support and training to Ukrainian scientists during this tragic period in the history of their country, so that when the war ends, they can return to Ukraine ready to rebuild scientific programs. The training provided to Dr. Starosyla will prepare her for a future research career in the overlap of neurobiology and virology.

抽象的 我们请求对 NINDS 资助的拨款 R01 NS124477“新型致病菌”提供行政补充 HIV相关中枢神经系统疾病的机制”为一名乌克兰人提供博士后职位资助 科学家 Daria Starosyla 博士将接手该项目的新研究方向，该项目由母公司资助。 授予，研究训练有素的免疫在神经炎症发病机制中所起的作用 手。我们最近的发现表明神经炎症可能“印记”在大脑骨髓和 到目前为止，我们已经证明了这一点。 外周血和骨髓髓细胞中的作用，进军脑细胞将是一个新的研究 神经生物学的发展并对母基金的所有具体目标做出了重大贡献。 Starosyla 在免疫学、病毒学和抗病毒治疗开发方面的经验，我们相信她很好 除了这一要求背后的科学原因之外，他还适合担任该项目这一部分的主导角色。 补充资金，还承载着乌克兰持续战争的人道主义和政治意义。 严重影响了国家所有的科学事业，不仅危及现在，而且危及未来 在这场悲剧期间，为乌克兰科学家提供支持和培训至关重要。 他们国家历史上的一段时期，这样当战争结束后，他们就可以返回乌克兰准备重建 为 Starosyla 博士提供的培训将为她未来的研究生涯做好准备。 神经生物学和病毒学的重叠。