Supplement to R01 NS124477

R01 NS124477 的补充

• 批准号: 10719354
• 负责人: MICHAEL Ilya BUKRINSKY
• 金额: $ 3.42万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10719354
• 关键词: Administrative Supplement; Affect; Bone Marrow; Brain; Cells; Country; Development; Distress; Exposure to; Funding; Future; Grant; HIV; HIV-1; Hand; Immune; Immunity; Immunology; Investigation; Myeloid Cells; National Institute of Neurological Disorders and Stroke; Neurobiology; Neuroglia; Pathogenesis; Pathogenicity; Play; Politics; Positioning Attribute; Postdoctoral Fellow; Recording of previous events; Research; Role; Scientist; Time; Training; Ukraine; War; antiviral drug development; brain cell; career; experience; extracellular vesicles; imprint; nef Protein; nervous system disorder; neuroinflammation; novel; parent grant; peripheral blood; programs; virology

Abstract We request an Administrative Supplement to our NINDS-funded grant R01 NS124477 ‘Novel pathogenic mechanism of HIV-associated CNS neurological disorders’ to fund a postdoctoral position for a Ukrainian scientist, Dr. Daria Starosyla. She will take over a new research direction in the project funded by the parent grant, investigation of the role that trained immunity plays in the neuroinflammation underlying pathogenesis of HAND. Our recent discoveries suggested a possibility that neuroinflammation is ‘imprinted’ in brain myeloid and glial cells by exposure to extracellular vesicles carrying HIV-1 protein Nef. So far, we have demonstrated this effect in peripheral blood and bone marrow myeloid cells, and the foray into the brain cells will be a novel development in neurobiology and contribute significantly to all Specific Aims of the parent grant. Given Dr. Starosyla’s experience in immunology, virology and development of anti-viral treatments, we believe she is well fit to take over the leading role on this part of the project. In addition to scientific reasons behind this request for Supplemental Funding, it also carries a humanitarian and political significance. The ongoing war in Ukraine severely affects all scientific enterprises in the country and endangers not only the present, but also the future scientific progress in Ukraine. It is critical to provide support and training to Ukrainian scientists during this tragic period in the history of their country, so that when the war ends, they can return to Ukraine ready to rebuild scientific programs. The training provided to Dr. Starosyla will prepare her for a future research career in the overlap of neurobiology and virology.

抽象的 我们要求对我们的Ninds资助的赠款R01 NS124477进行管理补充 艾滋病毒相关的中枢神经系统神经疾病的机制为乌克兰人提供博士后职位 科学家Daria Starosyla博士。她将接管父母资助的项目的新研究方向 授予，训练免疫学在神经炎症中扮演的作用的投资 手。我们最近的发现表明，神经炎症是在脑髓样中“烙印”的，并且 神经胶质细胞通过暴露于携带HIV-1蛋白NEF的细胞外蔬菜。到目前为止，我们已经证明了这一点 对外周血和骨髓髓样细胞的作用，脑细胞的锻造将是一种新颖的 神经生物学的发展，并为父母赠款的所有特定目标做出了重大贡献。给予博士 Starosyla在抗病毒治疗的免疫学，病毒学和发展方面的经验，我们认为她很好 适合在项目的这一部分中担任领导角色。除了此请求背后的科学原因 补充资金，它还具有人道主义和政治意义。乌克兰正在进行的战争 严重影响该国的所有科学企业，不仅危害现在，而且危害了未来 乌克兰的科学进步。在这一悲剧性期间，向乌克兰科学家提供支持和培训至关重要 在他们国家的历史上，当战争结束时，他们可以返回乌克兰准备重建 科学计划。向Starosyla博士提供的培训将为她做好准备，为未来的研究职业做好准备 神经生物学和病毒学的重叠。