University of Kentucky Markey Cancer Center – Cancer Center Support Grant

肯塔基大学马基癌症中心 — 癌症中心支持补助金

• 批准号: 10712114
• 负责人: Bernard Mark Evers
• 金额: $ 269.97万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-08 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10712114
• 关键词: Acceleration; Achievement; Address; Appalachian Region; Award; Basic Science; Behavioral; Bioinformatics; Biometry; Cancer Burden; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Patient; Catchment Area; Centers of Research Excellence; Climate; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Community Outreach; Comprehensive Cancer Center; Development; Devices; Education; Education and Outreach; Epigenetic Process; Faculty Recruitment; Flow Cytometry; Foundations; Funding; Genetic; Geography; Goals; Grant; Immunologic Monitoring; Incidence; Informatics; Infrastructure; Institution; International; Intervention; Intervention Studies; Intervention Trial; Investigational Therapies; Investments; Kentucky; Leadership; Legal patent; Link; Malignant Neoplasms; Mediator; Mentors; Metabolic; Metabolism; Methods; Mission; Molecular; NCI Center for Cancer Research; National Cancer Institute; Needs Assessment; Oncology; Outcome; Oxidation-Reduction; Paper; Participant; Pathology; Patients; Peer Review; Phase; Policies; Population; Population Sciences; Positioning Attribute; Preclinical Testing; Prevalence; Prevention; Program Development; Publications; Publishing; Quality of life; Research; Research Personnel; Resource Sharing; Resources; Risk Factors; Rural; Rural Appalachia; SEER Program; Science; Scientist; Series; Services; Shapes; Signal Transduction; Strategic Planning; Students; Textiles; Therapeutic Clinical Trial; Therapeutic Trials; Training; Training Programs; Training and Education; Translating; Translational Research; Underserved Population; Universities; Validation; Vision; Vulnerable Populations; Work; Workforce Development; Youth; acronyms; anticancer research; burden of illness; cancer care; cancer education; cancer genomics; cancer health disparity; cancer prevention; cancer risk; cancer site; cancer survival; career; cellular oncology; clinical practice; clinical translation; community engagement; community organizations; equity, diversity, and inclusion; expectation; health disparity; health equity; improved; in vivo; innovation; instrumentation; interdisciplinary collaboration; investigator-initiated trial; member; molecular oncology; mortality; neoplasm registry; next generation; novel therapeutics; patient oriented; personalized diagnostics; personalized therapeutic; precision medicine; programs; recruit; social; translational impact; translational oncology; translational pipeline; treatment response; tumor

PROJECT SUMMARY/ABSTRACT The Markey Cancer Center (MCC) is a university-based matrix cancer center at the University of Kentucky (UK) with a mission to reduce the cancer burden with a focus on Kentucky and its most vulnerable populations through research, prevention, treatment, education and community engagement. As the only National Cancer Institute (NCI)-designated Cancer Center in the state, the MCC is vital to Kentucky, the U.S. leader for highest all-site cancer incidence and mortality. Notably, recognition of the extraordinary disease burden in Kentucky’s vulnerable populations, as a significant underpinning of that national ranking, shapes the MCC vision and goals and drives its unique focus on prevalent cancers and cancer risk factors in the catchment population. Over $569M in state, institutional and philanthropic investment since 2009 has supported significant research and resource expansion, propelling new faculty recruitment, program development, clinical and shared resource space renovations, new state-of-the art instrumentation and statewide education and community outreach. MCC’s 159 members align with one of three MCC Research Programs: Cancer Prevention and Control, Molecular and Cellular Oncology and Translational Oncology, and are supported by seven Shared Resource Facilities that facilitate cutting-edge research via robust infrastructure, specialized expertise and advanced methods: Biospecimen Procurement and Translational Pathology, Biostatistics and Bioinformatics, Cancer Research Informatics, Flow Cytometry and Immune Monitoring, Oncogenomics, Patient-Oriented and Population Sciences and Redox Metabolism. Significant achievements in this funding period include an increased research depth and breadth as indicated by increased total cancer-relevant funding (41%), peer- reviewed funding (35%) and NCI funding (55%). Expanded transdisciplinary collaborations, driven in part through a strategic focus on precision medicine and a more streamlined translational pipeline, resulted in 26 new therapeutic trials, 8 concepts or devices in Phase I or II clinical trials, 10 agents or devices undergoing in vivo validation, 43 patent applications and 17 patents during the current funding period—all based on MCC science. In collaboration with other U.S. and international cancer centers, the number of U- and P-series grants awarded to the MCC increased by 80%. The number of member publications increased by 28% (total of 1,093) with 62% of the publications with cancer investigators at other institutions. Expanded education and training initiatives include a new NCI T32 focused on rural cancer health disparities, a new NCI R25 Youth Enjoy Science award to engage Appalachian students in cancer research and two new training programs emphasizing diversity, equity and inclusion. With unique research strengths and integrated statewide community outreach and engagement, MCC’s programs provide robust capacity to deliver transformative interventional research to Kentucky’s underserved populations, thereby contributing to national efforts to conquer cancer through discovery and clinical translation, cancer prevention and community outreach.

项目摘要/摘要 Marky癌症中心（MCC）是肯塔基大学的大学基质癌中心 （英国）旨在减少癌症伯恩的使命，重点是肯塔基州及其最脆弱的人群 通过研究，预防，治疗，教育和社区参与。作为唯一的全国癌症 该州指定的癌症中心，MCC对美国领导者肯塔基州至关重要 全部位癌症事件和死亡率。值得注意的是，肯塔基州对伯恩的非凡疾病的认识 脆弱的人口是该国家排名的重大基础，塑造了MCC的愿景和目标 并将其独特的重点放在流域人口中普遍的癌症和癌症危险因素上。超过 自2009年以来，州，机构和慈善投资的5.69亿美元支持了大量研究和 资源扩展，推动新教师招聘，计划开发，临床和共享资源 太空改革，新的最先进的工具以及全州教育和社区宣传。 MCC的159名成员与三个MCC研究计划之一：预防癌症和控制， 分子和细胞肿瘤学和翻译肿瘤学，并由七个共享资源支持 通过强大的基础架构，专业知识和高级研究来促进尖端研究的设施 方法：生物环形采购和转化病理学，生物统计学和生物信息学，癌症 研究信息学，流式细胞仪和免疫监测，致癌基因组学，面向患者和 人口科学和氧化还原代谢。在此资助期内取得的重大成就包括 研究深度和广度增加，如癌症总相关的资金增加（41％），同行 审查资金（35％）和NCI资金（55％）。扩大的跨学科合作，部分驱动 通过战略关注精密医学和更简化的翻译管道，导致26 新的治疗试验，8阶段或II临床试验中的8个概念或设备，10个正在进行的代理或设备 当前资金期间，体内验证，43项专利申请和17项专利 - 所有基于MCC 科学。与其他美国和国际癌症中心合作，U-和P系列赠款的数量 授予MCC的人增加了80％。会员出版物的数量增加了28％（总计1,093） 其他机构有62％的出版物与癌症调查员。扩大教育和培训 举措包括专注于粗糙癌症健康分布的新的NCI T32，新的NCI R25青年享受 科学奖使阿巴拉契亚学生参与癌症研究和两个新的培训计划 强调多样性，公平性和包容性。具有独特的研究优势和全州综合 社区外展和参与，MCC的计划提供了强大的能力来实现变革性 对肯塔基州服务不足的人群的介入研究，从而为国家努力做出了贡献 通过发现和临床翻译，预防癌症和社区外展来征服癌症。

项目成果

Designing a Framework for Remote Cancer Care Through Community Co-design: Participatory Development Study.

• DOI: 10.2196/29492
• 发表时间: 2022-04-12
• 期刊: Journal of medical Internet research
• 影响因子: 7.4
• 作者: Aronoff-Spencer E;McComsey M;Chih MY;Hubenko A;Baker C;Kim J;Ahern DK;Gibbons MC;Cafazzo JA;Nyakairu P;Vanderpool RC;Mullett TW;Hesse BW
• 通讯作者: Hesse BW

COVID-19 Test Strategy to Guide Quarantine Interval in University Student.

指导大学生隔离间隔的 COVID-19 检测策略。

• DOI: 10.1101/2020.12.09.20246785
• 发表时间: 2020
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Kolesar,JillM;Gayheart,Tyler;Poston,Lance;Monday,Eric;Forster,Derek;Belcher,Elizabeth;Jaiswal,Rani;Turner,JKirsten;Arnett,DonnaK;Durbin,EricB;Monroe,Joseph;Romanelli,Frank;Arnold,SusanneM;Jennings,CDarrell;Weiss,Heidi;D
• 通讯作者: D

Barriers and Facilitators to Stool-Based Screening for Colorectal Cancer Among Black Louisville Residents.

路易斯维尔黑人居民粪便筛查结直肠癌的障碍和促进因素。

• DOI: 10.1007/s13187-022-02231-2
• 发表时间: 2023
• 期刊: Journal of cancer education : the official journal of the American Association for Cancer Education
• 作者: Kruse-Diehr,AaronJ;Cegelka,Derek;Holtsclaw,Elizabeth;Stapleton,Jerod;Burnett,Camille;Wood,Rose;Combs,Carlee;Williams,LovoriaB
• 通讯作者: Williams,LovoriaB

Financial distress among cancer survivors in Appalachian Kentucky.

阿巴拉契亚肯塔基州癌症幸存者面临财务困境。

• DOI: 10.1002/cnr2.1221
• 发表时间: 2020
• 期刊: Cancer reports (Hoboken, N.J.)
• 作者: Vanderpool,RobinC;Chen,Quan;Johnson,MeghanF;Lei,Feitong;Stradtman,LindsayR;Huang,Bin
• 通讯作者: Huang,Bin

Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1.

• DOI: 10.1016/j.celrep.2023.112274
• 发表时间: 2023-03-28
• 期刊: Cell reports
• 影响因子: 8.8