New Classes of Electron Paramagnetic Resonance Imaging Probes With High-Spin Metal Complexes

具有高自旋金属配合物的新型电子顺磁共振成像探针

• 批准号: 10712009
• 负责人: Joseph M Zadrozny
• 金额: --
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10712009
• 关键词: Amendment; Anatomy; Chemicals; Chemistry; Dangerousness; Electron Spin Resonance Spectroscopy; Electronics; Electrons; Frequencies; Functional Imaging; Goals; Hybrids; Image; Inorganic Chemistry; Ions; Knowledge; Laboratories; Magnetic Resonance Imaging; Maps; Metals; Modernization; Molecular Probes; Physiological; Process; Property; Resolution; System; Techniques; Work; analog; biomedical imaging; body map; design; imaging probe; magnetic field; meetings; metal complex; microwave electromagnetic radiation; molecular imaging; non-invasive imaging

Project Summary/Abstract The focus of the Zadrozny laboratory is the design of metal complexes for noninvasive sensing of physiological chemistry. The broader goal of the effort is to make molecular probes that overcome inherent challenges in electron paramagnetic resonance imaging (EPRI), the unpaired electron analog to conventional 1H MRI. EPRI can sense local chemistry and could produce comprehensive chemical and anatomical maps of the body if merged with 1H MRI. Modern EPRI molecular imaging probes are organic radicals which require dangerous high-energy microwaves for use in the large magnetic field of an MRI scanner. Hence, the two techniques remain disconnected. For EPRI to enable imaging of physiological chemistry by integration with MRI, new probes must be developed to avoid high frequency microwaves at high magnetic fields. The next five years of the Zadrozny lab’s work involve exploring high-spin metal complexes as an alternative platform to radicals for molecular probes in EPRI. A key inherent advantage of metal ions is that the unique electronic feature of large zero-field splitting enables the possibility of safe, low-frequency microwave use at high magnetic field. Hence, metal complexes with this feature could provide a completely new set of EPRI molecular imaging probes with capabilities unmatched by organic radicals. However, all of the basic EPR spectral properties of metal complexes with low frequency microwaves are unmapped. The Zadrozny lab will amend this knowledge gap. The work will use synthetic inorganic chemistry and spectroscopic analyses to (1) understand how to target the frequency/field of the resonance to match the magnetic fields of MRI scanners with low-frequency microwaves (2) understand how to control the linewidth of the low-frequency EPR resonances to enhance resolution, and (3) how to merge radical/metal chemistry in hybrid molecules to gain the advantages of both metals and radicals for a single molecular probe system. Meeting these objectives will provide a new class of imaging probe capable of mapping physiological chemistry in a conventional MRI scanner.

项目摘要/摘要 Zadrozny实验室的重点是用于非侵入性感觉的金属配合物的设计 物理化学。努力的更广泛的目标是解决分子问题 克服电子顺磁共振成像（EPRI）中固有的挑战，未配对 电子类似于常规1H MRI。 EPRI可以感觉到局部化学反应，并可以产生 如果与1H MRI合并，则身体的综合化学和解剖图。现代EPRI 分子成像问题是有机自由基，需要危险的高能微波 用于MRI扫描仪的大磁场。因此，这两种技术仍然存在 断开连接。让EPRI通过与MRI整合进行新的化学成像 必须开发探针以避免在高磁场处的高频微波炉。下一个 Zadrozny Lab的五年工作涉及探索高旋转金属复合体作为一种 EPRI分子问题的自由基的替代平台。金属的关键继承优势 离子是，大零场拆分的独特电子特征使您有可能安全， 在高磁场上使用低频微波。因此，具有此功能的金属复合物 可以提供全新的EPRI分子成像问题，并具有功能 有机自由基无与伦比。但是，金属的所有基本EPR光谱特性 具有低频微波的复合物是未塑造的。 Zadrozny实验室将修改此事 知识差距。这项工作将使用合成无机化学和光谱分析 （1）了解如何靶向共振的频率/场以匹配磁场 具有低频微波的MRI扫描仪（2）了解如何控制线宽 低频EPR共振以增强分辨率，以及（3）如何合并自由基/金属 杂化分子中的化学性能获得金属和自由基的优势 分子探针系统。实现这些目标将提供新的成像探针 能够在常规的MRI扫描仪中绘制物理化学作用。