Sleep health in special populations

特殊人群的睡眠健康

• 批准号: 10737735
• 负责人: Jennifer L Martin
• 金额: $ 13.02万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-21 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10737735
• 关键词: Address; Adherence; Aftercare; Anxiety; Area; Attenuated; Award; Behavior; Behavioral; Clinical; Clinical Trials; Cognitive; Cognitive Therapy; Combined Modality Therapy; Comorbid Insomnia; Data Analyses; Dedications; Development; Disadvantaged; Discipline; Education; Educational Curriculum; Elderly; Environment; Epidemiology; Evidence based intervention; Exercise; Feeling suicidal; Funding; Geriatrics; Goals; Health; Hospitalization; Individual; Institutionalization; Intervention; Leadership; Learning; Los Angeles; Mental Depression; Mental Health; Mentors; Mentorship; Methodology; Methods; National Heart, Lung, and Blood Institute; Neurobehavioral Manifestations; Nurses; Outcome; Outcome Measure; Participant; Patient-Focused Outcomes; Patients; Physicians; Population; Population Heterogeneity; Populations at Risk; Post-Traumatic Stress Disorders; Process Measure; Psychologist; Quality of life; Randomized; Relaxation; Research; Research Personnel; Resources; Respiration Disorders; Risk; Scientist; Severities; Sleep; Sleep Apnea Syndromes; Sleep Deprivation; Sleep Disorders; Sleep Disorders Therapy; Sleeplessness; Special Population; Spinal cord injury patients; Stimulus; Symptoms; Techniques; Testing; Time; Training; United States National Institutes of Health; Veterans; Woman; Work; avoidance behavior; career; clinical center; comorbidity; comparative effectiveness; data dissemination; design; diaries; effectiveness evaluation; evidence base; experience; flexibility; follow-up; health disparity; implementation evaluation; implementation research; implementation science; improved; improvement on sleep; innovation; interest; leadership development; medical specialties; mindfulness; novel; patient oriented; patient oriented research; patient population; positive airway pressure; programs; psychiatric comorbidity; psychologic; randomized trial; reducing suicide; sleep health; sleep quality; sleep-focused interventions; theories; treatment response

PROJECT SUMMARY The goal of this renewal application is to provide support for mentoring of trainees and junior investigators in the areas of sleep disorders and sleep health among patient populations who are “at risk.” The applicant’s current research program focuses on treatment of sleep disorders in populations who have not been studied or who have achieved less benefit from current evidence-based interventions. This program provides rich opportunities for mentees to experience direct engagement in patient-oriented sleep research. Currently funded work focuses on veterans with comorbid insomnia disorder and post-traumatic stress disorder (PTSD) for whom standard cognitive-behavioral therapy for insomnia (CBT-I) is less acceptable and less efficacious than among individuals without PTSD. Based on emerging evidence that the theoretical underpinning and specific exercises of Acceptance and Commitment Therapy (ACT) present a viable approach to improving sleep when combined with evidence-based behavioral strategies, a novel ACT-based insomnia treatment, called "Acceptance and the Behavioral Changes to Treat Insomnia (ABC-I) is being tested in a clinical trial. ABC-I combines core behavioral components (sleep restriction, stimulus control, sleep hygiene, relaxation) with ACT-based techniques will be evaluated in a randomized trial. Using a comparative effectiveness design (n=200 randomized to ABC-I or cognitive-behavioral therapy for insomnia (CBT-I)), the primary aims of the study are to evaluate the benefits of ABC-I in reducing insomnia severity (non-inferiority) and PTSD symptoms (superiority) as compared to CBT-I. Additional aims address potential mechanisms of change from before to after treatment and explore potential ancillary benefits in terms of reducing other symptoms. The proposed analytic plan will simultaneously address superiority of ABC-I over CBT-I for improving PTSD symptoms and non-inferiority of ABC-I compared to CBT-I for improving insomnia symptoms. In addition to other ongoing and recently-completed projects, the study provides rich opportunities for trainees to engage in all aspects of patient-oriented research on sleep disorders, including direct interaction with research participants and engagement with data analysis and dissemination of findings. The research environment at UCLA and VAGLAHS is rich with opportunities for learning and for collaborative mentoring in areas of sleep health and sleep disorders. Building upon activities during the prior K- 24 award, the applicant will engage in formal leadership training and engage the support of a Leadership Development Council.

项目概要 此更新申请的目标是为培训生和初级研究人员的指导提供支持 申请人目前“处于危险之中”的患者群体的睡眠障碍和睡眠健康状况。 研究计划的重点是治疗尚未研究过的人群或患有睡眠障碍的人群 从当前基于证据的干预措施中获得的益处较少。该计划提供了丰富的机会。 让学员能够直接参与以患者为导向的睡眠研究。 患有共病失眠症和创伤后应激障碍（PTSD）的退伍军人的标准 与个体相比，失眠认知行为疗法 (CBT-I) 的接受度较低且疗效较差 没有 PTSD 的理论基础和具体练习的新证据。 接受与承诺疗法 (ACT) 提供了一种与以下方法相结合来改善睡眠的可行方法： 基于证据的行为策略，一种基于 ACT 的新型失眠治疗方法，称为“接受和 行为改变治疗失眠 (ABC-I) 正在临床试验中进行测试 ABC-I 结合了行为核心。 采用基于 ACT 的技术的组成部分（睡眠限制、刺激控制、睡眠卫生、放松）将 使用比较有效性设计（n=200 随机分配至 ABC-I 或 失眠认知行为疗法（CBT-I）），该研究的主要目的是评估认知行为疗法的益处 与 CBT-I 相比，ABC-I 在减轻失眠严重程度（非劣效性）和 PTSD 症状（优效性）方面。 其他目标涉及治疗前和治疗后潜在变化机制以及探索潜力 拟议的分析计划将同时解决减少其他症状方面的附带好处。 ABC-I 在改善 PTSD 症状方面优于 CBT-I，且 ABC-I 与 CBT-I 相比的非劣效性 除了其他正在进行和最近完成的项目外，该研究还旨在改善失眠症状。 为学员提供丰富的机会参与以患者为中心的睡眠障碍研究的各个方面， 包括与研究的直接互动以及参与数据分析和传播 加州大学洛杉矶分校和 VAGLAHS 的研究环境充满了学习和学习的机会。 以之前 K-期间的活动为基础，在睡眠健康和睡眠障碍领域进行协作指导。 24 获奖后，申请人将参加正式的领导力培训并获得领导力的支持 发展委员会。

项目成果

Use of alcohol as a sleep aid, unhealthy drinking behaviors, and sleeping pill use among women veterans.

女退伍军人使用酒精作为助眠剂、不健康的饮酒行为和使用安眠药。

• 发表时间: 2019-10
• 影响因子: 4.1
• 作者: Schweizer, C Amanda;Hoggatt, Katherine J;Washington, Donna L;Bean;Yano, Elizabeth M;Mitchell, Michael N;Alessi, Cathy A;Martin, Jennifer L
• 通讯作者: Martin, Jennifer L

How can we address poor sleep in nursing homes?

我们如何解决疗养院睡眠质量差的问题？

• 发表时间: 2021-03
• 影响因子: 7
• 作者: Martin, Jennifer L;Chodosh, Joshua
• 通讯作者: Chodosh, Joshua

Short Sleep, Insomnia, and Cardiovascular Disease.

睡眠不足、失眠和心血管疾病。

• 发表时间: 2019-12
• 影响因子: 1.8
• 作者: Hsieh, Caleb G;Martin, Jennifer L
• 通讯作者: Martin, Jennifer L