Improving Biopsies using Magnetic Nanoparticles

使用磁性纳米颗粒改善活检

基本信息

批准号：
7477619
负责人：
EDWARD R FLYNN
金额：
$ 33.47万
依托单位：
SENIOR SCIENTIFIC
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-07-20 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7477619
关键词：
Acute Lymphocytic Leukemia Acute Promyelocytic Leukemia Adjuvant Therapy Adopted Antibodies Antineoplastic Agents Applications Grants Area Aspirate substance Binding Biochemical Biocompatible Biological Biological Markers Biopsy Blood Tests Blood Vessels Blood specimen Bone Marrow Bone Marrow Involvement Bone marrow biopsy Breast Cancerous Cells Characteristics Child Chronic Myeloid Leukemia Clinical Clinical Trials Collecting Cell Collection Condition Cytometry Data Detection Development Disease Drug usage Dysmyelopoietic Syndromes Europe Excision Future Goals Heating Hodgkin Disease Human Human body Label Lead Left Life Lymphoma Magnetism Malignant Neoplasms Marrow Measurement Measures Metals Methodology Methods Microscopic Molecular Profiling Monitor Nanostructures Nanotechnology Nature Needle biopsy procedure Needles Numbers Ovarian Pain Patient Monitoring Patients Personal Satisfaction Phase Plastics Procedures Process Property Prostate Public Health Randomized Range Reporting Research Ethics Committees Residual Neoplasm Residual Tumors Sampling Sensitivity and Specificity Site Specificity Squid Staging Standards of Weights and Measures T-Cell Leukemia Techniques Testing Therapeutic Therapeutic Agents Therapeutic Intervention Time Tissues Woman angiogenesis base bcr-abl Fusion Proteins bone cancer cell cancer site cancer type cell type chemotherapy clinical application controlled release design experience hyperthermia treatment improved leukemia magnetic field malignant breast neoplasm millisecond movie nanoparticle nanosystems novel older patient outcome forecast particle peripheral blood prognostic programs radius bone structure sensor size tool

项目摘要

DESCRIPTION (provided by applicant): In children with acute lymphomatic leukemia (ALL) and in myelodysplastic syndrome (MDS) with older patients it is extremely important to measure the minimal residual disease (MRD) to monitor the progress of chemotherapy at early stages Such measurements determine the prognosis, efficacy, and levels of the treatment. The normal method for detection and monitoring is through bone marrow biopsies. Unfortunately, this method requires multiple biopsies to obtain sufficient samples and these must be made at periodic intervals to monitor the treatment. It is possible to substantially improve the efficiency of biopsies through the use of appropriately labeled magnetic nanoparticles and using magnetic collection methods. These antibody-labeled magnetic nanoparticles seek out, and attach themselves to, cancer cells, which can then be collected magnetically. This grant application describes the methodology behind this biopsy technique using a }smart} magnetic biopsy needle making it possible to substantially increase the efficiency of the biopsy as well as the specificity for particular leukemia cancer types but also including the sampling of metastatic rare cancer cells in the marrow. By using magnetic nanoparticles coated with anti-cancer agents and magnetically concentrated, direct therapeutic intervention at the cancer site is possible. PUBLIC HEALTH RELEVANCE: Nanotechnology for Disease Detection, Magnetic Nanoparticles for targeting Disease, Magnetic Needle for Bone Marrow Biopsy

描述（由申请人提供）：对于患有急性淋巴细胞白血病（ALL）的儿童和老年患者的骨髓增生异常综合征（MDS），测量微小残留病（MRD）以监测早期化疗的进展非常重要。确定治疗的预后、疗效和水平。检测和监测的常规方法是通过骨髓活检。不幸的是，这种方法需要多次活检才能获得足够的样本，并且必须定期进行活检以监测治疗情况。通过使用适当标记的磁性纳米粒子和使用磁性收集方法，可以显着提高活检的效率。这些抗体标记的磁性纳米粒子会寻找癌细胞并将其附着在癌细胞上，然后可以通过磁性方式收集癌细胞。该拨款申请描述了这种活检技术背后的方法，使用“智能”磁性活检针，可以大幅提高活检的效率以及特定白血病癌症类型的特异性，而且还包括对转移性罕见癌细胞进行采样。骨髓。通过使用涂有抗癌剂并磁性浓缩的磁性纳米颗粒，可以对癌症部位进行直接治疗干预。公共卫生相关性：用于疾病检测的纳米技术、用于靶向疾病的磁性纳米颗粒、用于骨髓活检的磁针