Pathophysiology of OSAS in Obese Children 8-17 Years Old

8-17 岁肥胖儿童 OSAS 的病理生理学

基本信息

批准号：
7588797
负责人：
Raanan Arens
金额：
$ 50.74万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-03-20 至 2012-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7588797
关键词：
17 year old Abdomen Accounting Adenoidal structure Adolescence Adolescent Medicine Affect African African American Americas Anatomy Apnea Architecture Area Biomechanics Biometry Body Weight Changes Body Weight decreased Body mass index Breathing Cardiovascular system Child Childhood Cognitive Continuous Positive Airway Pressure Coupled Data Development Devices Dimensions Enrollment Epidemiology Fatty acid glycerol esters Functional disorder Growth Health Hispanics Hour Hypertrophy Image Length Liquid substance Magnetic Resonance Imaging Measurement Measures Mechanics Methodology Monitor Morbidity - disease rate Morphology Neck New York City Obesity Obstructive Sleep Apnea Operative Surgical Procedures Patients Phase Physiological Population Predictive Value Prevalence Public Health Pulmonology Recruitment Activity Relative (related person)Reporting Research Design Research Personnel Resistance Respiration Risk Risk Factors Scheme Severities Sex Characteristics Sleep Structure Tonsil Visceral Wakefulness Weight Gain Weight maintenance regimen base computerized indexing inner city novel novel strategies nutrition pediatrician pharyngeal critical pressure pressure programs respiratory soft tissue subcutaneous

项目摘要

DESCRIPTION (provided by applicant): Obesity is the number one health concern for pediatricians today. Almost 20% of children in the United Sates have a body mass index (BMI) = 95th percentile standard. The prevalence of obesity in New York City is particularly high and reached 31% in Hispanic and 23% in African American children in 2002-2003. One of the most important obesity-associated risks for children is obstructive sleep apnea syndrome (OSAS), with a reported prevalence rate between 46-59% compared with 2% in the general pediatric population. OSAS in turn, contributes to significant cardiovascular and cognitive morbidities in children. However, the pathophysiology of OSAS in obese children and why some obese children have OSAS while others do not is still unknown. Accelerated somatic growth may compromise airway size as well as airway collapsibility. Our team of pediatric researchers with expertise in sleep, pulmonology, public health, nutrition, and adolescent medicine, coupled with experts in the field of epidemiology and biostatistics, MRI, and biomechanics will study the anatomical, functional, and mechanical mechanisms leading to OSAS in inner city obese children 8-17 years of age using novel non-invasive methodologies. Our main focus will be to determine the anatomic and functional risk factors relating obesity to OSAS that have predictive value for distinguishing between obese children who will or will not have or develop OSAS. Further, we will determine how adenotonsillectomy and weight changes (both weight loss and weight gain) modify the above proposed mechanisms leading to OSAS in this group of children. Project Narrative: Obesity is the number one health concern for pediatricians today. One of the most important associated risks for obese children is obstructive sleep apnea syndrome (OSAS). This study will determine the anatomic and functional risk factors related to obesity and OSAS in inner city children 8-17 years of age using physiological studies coupled with novel imaging and computerized methodology.

描述（由申请人提供）：肥胖是当今儿科医生的头号健康问题。几乎20％的联合儿童具有体重指数（BMI）= 95％的标准。纽约市的肥胖症患病率特别高，在2002 - 2003年的西班牙裔肥胖症中达到31％，非裔美国人儿童的患病率达到31％。与肥胖相关的最重要的儿童风险之一是阻塞性睡眠呼吸暂停综合征（OSA），据报道的患病率在46-59％之间，而普通儿科人口为2％。 OSA反过来，有助于儿童的大量心血管和认知病变。但是，肥胖儿童中OSA的病理生理学以及为什么有些肥胖儿童患有OSA而另一些肥胖儿童的病理学仍然未知。加速的体细胞生长可能会损害气道大小以及气道可折叠性。我们在睡眠，肺病学，公共卫生，营养和青少年医学方面具有专业知识的儿科研究人员团队，再加上流行病学和生物统计学领域，MRI和生物力学领域的专家，将研究解剖学，功能性，功能性，功能性，机械机制，并使用新颖的NOMEN INMINIVE INVAS INVAS INVAS Invas VAINGIAD INV ADIVE INVAS Invas INVAS Invas VAINGIAD INV ADVAS Invas VAINCAL INV ADVAS INV的机制。我们的主要重点是确定肥胖与OSA有关的解剖和功能危险因素，这些因素与OSA有关，这些因素具有预测价值，以区分肥胖的儿童，而肥胖儿童将或将不会有或不会发展OSA。此外，我们将确定腺孔切除术和体重变化（体重减轻和体重增加）如何改变上述提议的机制，导致这组儿童的OSA。项目叙述：肥胖是当今儿科医生的第一名。肥胖儿童最重要的相关风险之一是阻塞性睡眠呼吸暂停综合征（OSA）。这项研究将通过生理研究以及新型成像和计算机化方法的生理学研究确定与肥胖和OSA有关的解剖和功能危险因素8-17岁。