Patient-Oriented Research in Global Cardiovascular Diseases and Interactions with HIV

全球心血管疾病及其与艾滋病毒相互作用的以患者为导向的研究

• 批准号: 10762609
• 负责人: Robert N Peck
• 金额: $ 12.63万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10762609
• 关键词: AIDS prevention; Address; Adolescent; Adult; Africa; African; Ambulatory Care Facilities; Award; Biological Markers; Blood Pressure; Cardiovascular Diseases; Caring; Chronic Disease; Clinic; Clinical; Clinical Investigator; Clinical Trials; Cluster randomized trial; Communities; Community Health Aides; Development; Diagnosis; Diastolic heart failure; Disease; Echocardiography; Environment; Event; Eye; Faculty; Family; Fellowship; Foundations; Functional disorder; Funding; Galectin 3; Goals; Grant; Guidelines; HIV; Heart; Hospital Mortality; Hospitalization; Hospitals; Hybrids; Hypertension; Institution; Interdisciplinary Study; International; Intervention; Kenya; Kidney; Leadership; Learning; Life Style; Link; Low income; Medicine; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Modeling; Morbidity - disease rate; Myocardial dysfunction; Nursing Faculty; Organ; Patients; Persons; Pharmaceutical Preparations; Physicians; Plasma; Population; Prevention therapy; Privatization; Productivity; Proteins; Proteomics; Reference Standards; Religion; Research; Research Personnel; Research Project Grants; Research Training; Risk Factors; Role; Rural; Sampling; Schools; Scientist; Site; Sleep; Social Workers; Tanzania; Testing; Time; Training; Troponin I; Trust; United States; United States National Institutes of Health; biobank; biomarker identification; blood pressure elevation; blood pressure reduction; cardiovascular disorder epidemiology; cardiovascular disorder prevention; cardiovascular disorder risk; clinical implementation; cohort; community center; community engagement; cost; cost effective; design; empowerment; evidence base; experience; follow-up; health disparity; hypertension treatment; hypertensive; implementation science; implementation trial; implementation/effectiveness; improved; innovation; medical schools; member; mortality; novel; novel marker; patient oriented; patient oriented research; point of care; point of care testing; poor communities; poor sleep; predictive marker; prevent; pro-brain natriuretic peptide (1-76); research study; risk stratification; skills; training opportunity; young adult

ABSTRACT: The goals of this K24 application are for Dr. Robert Peck to train physician-scientists in the conduct of patient-oriented cardiovascular disease (CVD) research in East Africa, and to conduct a new study of novel biomarkers predicting the onset of diastolic dysfunction of the heart (Aim 1). The candidate has lived and conducted research in Tanzania for the past 15 years. He helped to establish a new medical college and developed longstanding partnerships with leading research organizations in Tanzania (MITU) and Kenya (KWTRP). These partnerships, with the ongoing research studies, provide him with an outstanding research environment to study CVD in the context of Africa while also training a cadre of young investigators. The training that he offers leverage 3 NIH R01 funded projects in Tanzania (Aims 2-4), foundation awards (Aim 5), and a newly funded CVD research project in Kenya (Aim 6). United States (US) trainees from Weill Cornell Medicine will be supported by NIH T32 training grants and spend ~50% of their time at research sites in East Africa, which have longstanding international collaborators and excellent research training environments. East African trainees will be supported by two NIH D43 training grants and institutional funds. The common theme is that all of the research projects have patient-oriented research on CVD as the focus, with an emphasis on interactions with HIV, and will serve as vehicles for mentored research training. The specific aims include: 1. Biomarkers for incident diastolic dysfunction in people living with HIV (PLWH) in Tanzania 2. HIV, sleep, nocturnal blood pressure, and CVD in Tanzania 3. A cluster randomized trial of engaging religious leaders to reduce blood pressure in Tanzania 4. Reducing post-hospital mortality related to severe hypertension in Tanzania 5. Causes and consequences of hypertension in adolescents in Tanzania 6. Point-of-care risk stratification for community-centered hypertension treatment in Kenya The focus of research training will be on a diverse pool of clinical trainees, ranging from residents to fellows to clinical faculty. The candidate has a strong track record of mentoring patient-oriented researchers in Tanzania and participates in multiple private and NIH sponsored research fellowships at Weill Cornell. Trainees will participate in research projects in Tanzania (Aims 1-5) and also in Kenya (Aim 6). Trainees learn through the conduct of their mentored research project and partnerships with colleagues from the US and East Africa on related studies. The K24 award will enable the candidate to decrease his administrative responsibilities and commit at least 25% effort to CVD research mentorship of US and Tanzanian trainees. As part of the K24, he will pursue formal training in mentorship as well as strengthening his skills in translational biomarker research.

摘要：此 K24 应用程序的目标是 Robert Peck 博士在以下领域培训医师科学家： 在东非开展以患者为导向的心血管疾病（CVD）研究，并开展一项新研究 预测心脏舒张功能障碍发作的新型生物标志物（目标 1）。候选人曾住过 过去15年在坦桑尼亚进行了研究。他帮助建立了一所新的医学院并 与坦桑尼亚 (MITU) 和肯尼亚的领先研究组织建立了长期合作伙伴关系 （KWTRP）。这些合作伙伴关系以及正在进行的研究为他提供了杰出的研究成果 为在非洲研究心血管疾病提供了环境，同时还培训了一批年轻的研究人员。这 他提供的培训杠杆 3 个 NIH R01 资助的坦桑尼亚项目（目标 2-4）、基金会奖项（目标 5）、 以及肯尼亚新资助的 CVD 研究项目（目标 6）。来自威尔康奈尔大学的美国（US）实习生 医学将得到 NIH T32 培训补助金的支持，并将约 50% 的时间花在东部的研究地点 非洲拥有长期的国际合作者和优良的研究培训环境。东方 非洲学员将获得两项 NIH D43 培训补助金和机构基金的支持。共同的主题是 所有的研究项目都以以患者为中心的CVD研究为重点，重点是 与艾滋病毒的相互作用，并将作为指导研究培训的工具。具体目标包括： 1. 坦桑尼亚艾滋病毒感染者 (PLWH) 发生舒张功能障碍的生物标志物 2. 坦桑尼亚的艾滋病毒、睡眠、夜间血压和心血管疾病 3. 坦桑尼亚一项让宗教领袖参与降低血压的整群随机试验 4. 降低坦桑尼亚与严重高血压相关的院后死亡率 5. 坦桑尼亚青少年高血压的原因和后果 6. 肯尼亚以社区为中心的高血压治疗的护理点风险分层 研究培训的重点将放在各种临床实习生身上，从住院医生到研究员，再到 临床教师。该候选人在指导坦桑尼亚以患者为中心的研究人员方面拥有良好的记录 并参加了威尔康奈尔大学的多项私人和美国国立卫生研究院资助的研究奖学金。学员将 参与坦桑尼亚（目标 1-5）和肯尼亚（目标 6）的研究项目。学员通过以下方式学习 开展他们指导的研究项目并与来自美国和东非的同事建立伙伴关系 相关研究。 K24 奖项将使候选人能够减少其行政职责和 投入至少 25% 的精力用于对美国和坦桑尼亚学员的 CVD 研究指导。作为 K24 的一员，他 将接受正规的指导培训，并加强转化生物标志物研究的技能。