Metabolic Dysregulation and Cancer Risk Program: Coordinating Center

代谢失调和癌症风险计划：协调中心

• 批准号: 10707116
• 负责人: LORETTA DIPIETRO
• 金额: $ 60.08万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707116
• 关键词: Acceleration; Adolescent; Affect; Agreement; Area; Bioinformatics; Biological; Biological Process; Biometry; Body Composition; Clinical Trials; Clinical Trials Data Monitoring Committees; Collaborations; Communication; Complications of Diabetes Mellitus; Computational Biology; Data; Data Analyses; Data Collection; Data Reporting; Data Set; Department chair; Development; Diabetes Mellitus; Ensure; Epidemiology; Etiology; Event; Exercise; Faculty; Fostering; Future; Goals; Grant Review; Human; Individual; Information Dissemination; Information Systems; Institution; Intervention; Journals; Lead; Leadership; Link; Logistics; Manuals; Maternal-Fetal Medicine Units Network; Measurement; Measures; Metabolic; Metabolic Pathway; Metabolism; Methods; Molecular; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome Study; Output; Pathway interactions; Pilot Projects; Policies; Prevention strategy; Privatization; Protocols documentation; Public Health Schools; Qualifying; Recording of previous events; Reporting; Research; Research Personnel; Resources; Science; Self Correction; Self-Examination; Signal Transduction; Site; System; Training; Universities; Washington; Work; Youth; archive data; cancer initiation; cancer prevention; cancer risk; cancer type; comparative effectiveness study; data archive; data harmonization; data infrastructure; data management; data repository; data resource; data sharing; design; diabetes control; diabetes prevention program; editorial; experience; flexibility; innovation; insulin secretion; meetings; member; multidisciplinary; novel; nutrition; obesity prevention; operation; outreach; programs; research study; scientific hub; skills; success; web site; working group

PROJECT SUMMARY The goal of the Metabolic Dysregulation and Cancer Risk Consortium (MDCRC) is to identify tangible mechanistic/etiologic pathways that link obesity-related metabolic dysregulation with cancer risk to inform cancer prevention strategies. The Consortium proposes to accomplish this through developing common measures for obesity-related metabolic dysregulation for different cancer types, understanding how obesity- related metabolic dysregulation affects cancer initiation and development, characterizing signal cross-talk between key biologic processes that impact obesity-associated metabolic dysregulation and cancer risk, and determining the utility of emerging approaches for the discovery of novel obesity-associated metabolic targets in cancer risk and prevention. The Biostatistics Center (Center) in the Milken Institute School of Public Health (SPH) of the George Washington University (GW), the participating institution, proposes to serve as the MDCRC Coordinating Center (CC). The MDCRC CC will integrate this expertise and experience, drawing upon our successful history of coordinating center leadership in collaborative research consortia, capacity for innovation, and the extensive scientific expertise in obesity and cancer prevention, nutrition, exercise, metabolism, body composition, and bioinformatics/computational biology to form a CC that is rooted in scientific rigor and is flexible and responsive to the diverse challenges and scientific opportunities of the MDCRC. The specific aims of the MDCRC include to 1) provide scientific leadership and project management for collaborative cross-Consortium activities, including providing guidance on the selection of common measures and development of consistent protocols and manuals of operations, maintain private and public websites, establishing topical work groups, and spearhead outreach activities; 2) facilitate data harmonization, data sharing and results dissemination across the MDCRC sites and with NCI, including identification of opportunities for novel data collection to enrich the MDCRC data resources, developing a common data management platform, and training for site staff; and 3) establish a Self-Evaluation Core to promote timely self- evaluation, along with effective self-correcting actions, working with NCI and the Consortium investigators to establish criteria and outputs related to the “success” of individual investigators, study teams, and Consortium sites.

项目摘要 代谢性疏调和癌症风险联盟（MDCRC）的目的是确定有形的 将肥胖相关代谢失调与癌症风险联系起来的机械/病因途径以告知 癌症预防策略。 与肥胖相关的代谢失调的不同癌症类型的措施，了解肥胖如何 相关的代谢失调会影响CANCTS癌化和发育，表征信号交叉对话 在影响肥胖相关的代谢失调和癌症风险的关键生物过程之间 确定新兴方法的实用性，以发现与新闻相关的代谢靶标的 在癌症风险和预防中。 乔治米尔肯学院公共卫生学院（SPH）的生物统计中心（中心） 参与机构华盛顿大学（GW）提议作为MDCRC协调 中心（CC）。 协调中心领导协作研究联盟，创新能力和广泛的 肥胖和癌症科学专业知识 生物信息学/计算生物学，形成植根于科学严谨的CC，是灵活的，反应 MDCRC的各种挑战和科学机会。 MDCRC的具体目的包括1）为科学领导和项目管理提供 协作跨心情活动 以及开发合唱和操作手册，维护私人和公共网站， 建立局部工作组和矛头外展活动； 2）促进数据协调 在MDCRC站点和NCI上共享和结果纪念活动，包括确定 将新型数据收集到MDCRC数据资源的机会，开发常见数据 管理平台和网站工作人员的培训； 3）建立一个自我评估的核心 评估，以及有效的自我校正行动，也与NCI和配偶者合作 建立与个人调查人员，研究团队和财团的“成功”有关的标准和产出 站点。