Four-dimensional multi-modality microimaging-microdevice system for high throughput drug screening in vivo

用于高通量体内药物筛选的四维多模态显微成像-微器件系统

基本信息

批准号：
10707307
负责人：
Guigen Liu
金额：
$ 17.28万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-30 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10707307
关键词：
3-Dimensional 4D Imaging Adoption Award Biomedical Research Biopsy Calibration Catheters Cell Death Cells Clinical Clinical Oncology Color Custom Dependence Development Development Plans Diffusion Doctor of Philosophy Dose Drug Delivery Systems Drug Evaluation Drug Exposure Engineering Environment Evaluation Event Excision Fiber Optics Fluorescence Four-dimensional Future Generations Goals Healthcare Histologic Hospitals Image Imaging Device Imaging technology Immune Implant In Situ In Vitro Intervention Investigation Label Laboratories Laboratory Research Lasers Learning Length Location MC38 Manuscripts Massachusetts Mechanics Mentors Methods Microscopy Needles Optics Organ Paper Patients Pharmaceutical Preparations Procedures Protocols documentation Publications Publishing Quantitative Evaluations Radiology Specialty Raman Spectrum Analysis Reporting Research Research Activity Research Personnel Resolution Resources Signal Transduction Silicon Site Skin Tissue Speed Subcutaneous Tissue System Systems Development Technology Testing Three-Dimensional Imaging Time Tissues Training Training Activity Translating Tumor Tissue Visualization Woman brain tissue career career development clinical application design drug development drug efficacy drug testing experience experimental study flexibility fluorescence imaging high throughput technology high-throughput drug screening imaging probe imaging system immune cell infiltrate in vivo in vivo evaluation in vivo imaging innovation instructor interest leadership development lens medical schools microdevice minimally invasive multimodality optical fiber optical imaging post-doctoral training programs quantitative imaging response sensor technology skill acquisition skills standard of care success tool translational oncology tumor two-dimensional two-photon

项目摘要

Project Summary Guigen Liu, Ph.D., is a mechanical and optical engineer whose overarching career goal is to develop and translate optical fiber based biomedical optical imaging and sensing technologies. The research, entitled “Four- dimensional multi-modality microimaging-microdevice system for high throughput drug screening in vivo”, combines the advanced optical microimaging system with an emerging microdevice, which has the huge potential impact on drug development, individualized health care, and fundamental biomedical research. Candidate: Dr. Liu is an Instructor at the Radiology Department of Brigham and Women’s Hospital, Harvard Medical School. During his previous postdoctoral training, he and colleagues pioneered a silicon-tipped fiber- optic sensing platform featuring high speed and high resolution, which earned the 2015 Alan Berman Research Publication Award from the U.S. Naval Research Laboratory. While Dr. Liu has shown a successful track of record in engineering, his training in biomedical research is limited. Through the career development plans: 1) Gain more experience in two-photon fluorescence and Raman microimaging; 2) Learn to design and implement the microimaging-microdevice system; 3) Establish in vivo drug delivery and tissue response testing skills; and 4) Enhance leadership and career development skills, Dr. Liu will launch his independent career in the new field. Mentors/Environment: Dr. Liu has assembled a strong team of mentors to guide him through the proposed training and research activities. The proposed career development plan includes the rich resources available through Brigham & Women’s Hospital and Harvard Medical School, the Tearney Laboratory at the Wellman Center for Photomedicine, and the Laser Biomedical Research Center at Massachusetts Institute of Technology. Research: The research seeks to build an in situ multi-modality optical histological laboratory for the biomedical microdevice, through four specific research aims: 1) To implement quantitative 4D multi-color two-photon fluorescence microimaging; 2) To test drug efficacy in vivo using the 4D two-photon fluorescence MI-MD system; 3) To develop label-free MI-MD system using Raman microscopy; and 4) To investigate microimaging through long and flexible GRIN probes. Completion of these aims will push the microdevice a big step toward potential clinical adoptions in the future. Summary: Innovation of the proposed research is the integration of 3D microimaging and microdevice for 4D testing of drug efficacy and tissue response in vivo, which will meet the pressing needs of high throughput drug screening. The candidate has identified a group of experts who provide complementary training and mentoring on all the aspects for him to complete the proposed research and develop an independent research career.

项目概要 Guigen Liu 博士是一名机械和光学工程师，其首要职业目标是开发和翻译基于光纤的生物医学光学成像和传感技术，题为“四-”。 “用于体内高通量药物筛选的多维多模态微成像-微器件系统”，将先进的光学显微成像系统与新兴的微型器件相结合，具有巨大的对药物开发、个性化医疗保健和基础生物医学研究的潜在影响。候选人：刘博士是哈佛大学布莱根妇女医院放射科讲师在他之前的博士后培训期间，他和同事开创了一种硅尖光纤- 具有高速、高分辨率的光学传感平台，荣获2015年Alan Berman Research奖刘博士获得了美国海军研究实验室的出版奖。由于他在工程方面的记录，他在生物医学研究方面的培训是有限的。通过职业发展计划：1）。获得更多双光子荧光和拉曼显微成像的经验2）学习设计和实现； 3）建立体内药物输送和组织反应测试技能； 4）增强领导力和职业发展能力，刘博士将在新的领域开启他的独立职业生涯。导师/环境：刘博士组建了一支强大的导师团队来指导他完成拟议的项目拟议的职业发展计划包括丰富的可用资源。通过布莱根妇女医院和哈佛医学院、韦尔曼医院的蒂尔尼实验室麻省理工学院光医学中心和激光生物医学研究中心。研究：该研究旨在为生物医学建立原位多模态光学组织学实验室微器件，通过四个具体研究目标：1）实现定量4D多色双光子荧光显微成像；2) 使用4D双光子荧光MI-MD系统测试体内药效； 3) 使用拉曼显微镜开发无标记 MI-MD 系统；4) 通过研究显微成像；长而灵活的 GRIN 探针的完成将推动微型设备向潜力迈出一大步。未来临床采用。摘要：本研究的创新之处在于 3D 微成像和 4D 微器件的集成体内药效和组织反应测试，满足高通量药物的迫切需求筛选候选人已确定一组提供补充培训和指导的专家。在所有方面帮助他完成拟议的研究并发展独立的研究生涯。