Micro-randomized trial of a physical activity intervention to manage pain symptoms among older cancer survivors

体力活动干预治疗老年癌症幸存者疼痛症状的微随机试验

• 批准号: 10707890
• 负责人: Whitney A Morelli
• 金额: $ 13.49万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707890
• 关键词: Activities of Daily Living; Affect; Age; Algorithms; Applications Grants; Area; Award; Behavioral Model; Cancer Survivor; Cancer Survivorship; Data; Development; Development Plans; Elderly; Experimental Designs; Feedback; Foundations; Funding; Future; Glean; Health; Hour; Individual; International; Intervention; K-Series Research Career Programs; Knowledge; Maintenance; Malignant Neoplasms; Measurement; Mentors; Mentorship; Monitor; Nature; Notification; Pain; Pain management; Participant; Patient Self-Report; Personal Satisfaction; Persons; Physical Function; Physical activity; Population; Probability; Psyche structure; Quality of life; Randomized, Controlled Trials; Recommendation; Recording of previous events; Research; Research Personnel; Risk; Risk Reduction; Survivors; Symptoms; Technology; Testing; Time; Training; Work; adaptive intervention; career development; chronic pain; design; disability; discrete time; exercise intervention; experience; health communication; health literacy; human old age (65+); improved; intervention delivery; mortality; novel; pain reduction; pain symptom; patient oriented; patient population; persistent symptom; physical conditioning; physical symptom; preservation; programs; psychosocial; randomized trial; reduce symptoms; sedentary; side effect; skills; theories; therapy design; time use; trial design

PROJECT SUMMARY/ABSTRACT The older cancer survivor is particularly affected by cancer and its treatments with numerous physical, mental, and psychosocial short- and long-term side effects, such as an increase in risk to experience chronic pain symptoms. Strong evidence indicates physical activity is correlated with lower rated symptoms of chronic pain. Despite the known benefits of physical activity, only 7% of older cancer survivors meet current physical activity recommendations. High ratings of pain are associated with low physical activity levels in older cancer survivors. Therefore, it is critical to understand how and when to best deliver physical activity intervention health messaging to reduce chronic pain symptoms among older cancer survivors who experience chronic pain symptoms. This application proposes the career development plan for Dr. Whitney Welch to establish an independent research program examining the relationship between physical activity and the maintenance of independence through the reduction of chronic symptoms among older cancer survivors. Dr. Welch's career development will be supported by an exceptional interdisciplinary group of investigators with a lengthy history of federal funding and a track record of successful mentorships. Her mentors, Dr. Rini, Dr. Spring, and Dr. Wolf are internationally recognized scholars in the areas of cancer survivorship, adaptive intervention design, and health literacy and health communications, respectively. The overall aim of this application is to develop and test the timing of physical activity promotion messages to increase physical activity and reduce pain symptoms among older cancer survivors who experience chronic pain symptoms using a micro-randomized trial design. In Aim 1, we propose to use a patient-centered, health literacy approach to develop and select theory-based health messaging that increase survivors' likelihood of engaging in physical activity tailored to their current pain symptoms. In Aim 2, we will conduct a micro-randomized trial, a new experimental design developed to optimize the construction of in-the-moment interventions, to determine the optimal pain state (pain/no pain) to deliver a message to increase physical activity and the probability that older cancer survivors will engage in physical activity. Finally, we propose an exploratory aim to determine the optimal pain state (pain/no pain) to deliver the message to increase physical activity and the probability participants will experience a subsequent pain episode. Results from this study will provide a robust foundation for a R01 submission to conduct a just-in- time adaptive physical activity intervention to manage pain symptoms in older cancer survivors. This award will directly lead to the establishment of an independent research program in physical activity and health research among older cancer survivors.

项目摘要/摘要 老年癌症幸存者特别受到癌症及其治疗的影响 和社会心理短期和长期副作用，例如体验慢性疼痛的风险增加 症状。有力的证据表明，体育活动与慢性疼痛的评分症状较低相关。 尽管有体育锻炼的已知好处，但只有7％的老癌症幸存者符合当前的体育活动 建议。疼痛的高评分与老年癌的身体活动水平低有关 幸存者。因此，了解如何以及何时最好地提供身体活动干预 健康消息传递以减少经历慢性的老年癌症幸存者的慢性疼痛症状 疼痛症状。该申请建议惠特尼·韦尔奇博士建立职业发展计划 独立研究计划，研究身体活动与维护之间的关系 通过减少老年癌症幸存者慢性症状的独立性。韦尔奇博士的职业 开发将得到一个杰出的跨学科研究人员的支持 联邦资金和成功指导的记录。她的导师Rini博士，Spring博士和沃尔夫博士 是癌症生存，适应性干预设计和 健康素养和健康传播。该应用程序的总体目的是开发和 测试体育活动促进信息的时间，以增加身体活动并减轻疼痛症状 在老年癌症幸存者中，他们使用微型试验设计经历了慢性疼痛症状。 在AIM 1中，我们建议使用以患者为中心的健康素养方法来开发和选择基于理论的方法 健康消息传递增加了幸存者从事当前疼痛量身定制的体育活动的可能性 症状。在AIM 2中，我们将进行微型试验，这是一种新的实验设计 优化瞬间干预措施的构建，以确定最佳疼痛状态（疼痛/无疼痛） 传递信息以增加体育锻炼以及老年癌症幸存者参与的可能性 体育锻炼。最后，我们提出了一个探索目的，以确定最佳疼痛状态（疼痛/无疼痛） 传递信息以增加体育锻炼，概率参与者将经历随后的 痛苦情节。这项研究的结果将为R01提交提供强大的基础，以进行公正 时间适应性体育锻炼干预以管理老年癌症幸存者的疼痛症状。这个奖项将 直接导致建立一个独立的体育活动和健康研究计划 在老年癌症幸存者中。