Semi-volatile PCBs: Sources, Exposures, Toxicities

半挥发性多氯联苯：来源、暴露、毒性

• 批准号: 7232425
• 负责人: LARRY W ROBERTSON
• 金额: $ 296.21万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-12 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7232425
• 关键词: Semi; volatile; PCBs; Sources; Exposures

DESCRIPTION (provided by applicant) The Superfund basic research program at the University of Iowa (ISBRP) is a joint endeavor involving basic, mechanistic and applied projects in biomedical and non-biomedical research areas. The program's overall theme is the consequences of atmospheric sources and exposures to semi-volatile Polychlorinated Biphenyls (PCBs), and it deals with volatilization, transport and exposure of lower halogenated PCBs, especially those PCBs that are associated with contaminated waters, former industrial sites, other atmospheric sources, and the consequences of exposure to them. We plan to identify routes of exposure with an eye to preventing or limiting exposure and ameliorating the effects. The ISBRP brings together 15 scientists, representing 5 departments in 4 colleges. Working together, they will measure sources, transport and environmental exposure of PCBs (project #4 and #6); their distribution, metabolism and toxicity in animals and humans (project #1, #2 and #3); and novel methods of phytoremediation (project #5). Studies include a community-based participatory research project-an assessment of exposures to citizens who live or work in the vicinity of sources of lower chlorinated PCBs in the Chicago Metropolitan area. We enjoy the cooperation of citizen groups in Chicago, where many ethnic-minority citizens are living below the poverty line near deindustrialized sites. Our research projects and overall efficiency are supported by seven cores- Administration, Synthesis, Analytical, Inhalation Toxicology, Training, Research Translation and Community Outreach -through which program and project administrators will oversee coordination, information transfer, design and analysis of experiments, and assessment of research. The assessment process culminates in an annual meeting of our 8-member External Advisory Committee. The Synthesis Core will synthesize all compounds/mixtures to be studied while the Analytical Core provides critical compositional information from metabolism to movement. Community Outreach and Research Translation Cores will transmit research findings to a variety of stakeholders and involve those stakeholders in research activities. A Training Core and the research projects provide for the training of more than 20 students and postdoctoral scholars. Overall this multidisciplinary program brings abroad range of experience and expertise to bear on problems associated with Superfund chemicals that are critical to the Midwest and the nation.

描述（由申请人提供） 爱荷华大学（ISBRP）的超级基础研究计划是一项联合努力，涉及生物医学和非生物医学研究领域的基本，机械和应用项目。该计划的总体主题是大气来源和对半挥发性多氯化双苯基（PCB）暴露的后果，它涉及下卤代PCB的挥发，运输和暴露，尤其是那些与受污染的水域相关的PCB，既遭受污染的水域，前工业地点，其他大气来源，以及对他们的影响。我们计划确定暴露途径，以防止或限制暴露并改善影响。 ISBRP汇集了15位科学家，代表4所大学的5个系。他们将共同努力，测量PCB的来源，运输和环境暴露（项目＃4和＃6）；它们在动物和人类中的分布，代谢和毒性（项目＃1，＃2和＃3）；和新颖的植物修复方法（项目＃5）。研究包括一个基于社区的参与性研究项目 - 对在芝加哥大都市地区居住或工作附近生活或工作的公民的接触评估。我们喜欢在芝加哥的公民团体的合作，许多种族少数公民都住在去工业化地点附近的贫困线以下。我们的研究项目和整体效率得到了七个核心管理，合成，分析，吸入毒理学，培训，研究翻译和社区外展的支持 - 通过哪些计划和项目管理员将监督协调，信息传输，实验设计和研究分析以及研究评估。评估过程最终在我们由8名成员的外部咨询委员会的年度会议上达到顶峰。合成核心将合成所有要研究的化合物/混合物，而分析核心提供从代谢到运动的关键组成信息。社区宣传和研究翻译核心将将研究结果传输给各种利益相关者，并使这些利益相关者参与研究活动。培训核心和研究项目提供了20多名学生和博士后学者的培训。总体而言，这个多学科计划为国外的经验和专业知识带来了与中西部和国家至关重要的超级基金化学物质有关的问题。