Space Optimization, Allergen Mitigation, and Improved Microenvironmental Conditions in a Shared Use Animal Facility at Florida State University

佛罗里达州立大学共享动物设施的空间优化、过敏原缓解和改善微环境条件

• 批准号: 10735627
• 负责人: William Allen Hill
• 金额: $ 34.93万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10735627
• 关键词: Agriculture; Air; Allergens; Ammonia; Animal Welfare; Animals; Area; Biological Sciences; Biomedical Research; Carbon Dioxide; Data Science; Engineering; Enrollment; Ensure; Environment; Exposure to; Faculty; Florida; Funding; Future; Goals; Growth; Health Personnel; Human Resources; Humidity; Immunocompromised Host; Individual; Infrastructure; Investigation; Laboratory Animals; Location; Mechanics; Medical Research; Medical Students; Mentors; Modernization; Modification; Monitor; Mus; Occupational; Occupational Health; Oxygen; Positioning Attribute; Publishing; Rattus; Request for Proposals; Research; Research Personnel; Risk; Rodent; Safety; Sampling; Side; System; Technology; Temperature; Translating; United States National Institutes of Health; Universities; Work; air sampling; animal care; animal facility; animal resource; effectiveness evaluation; effectiveness testing; experience; health data; improved; innovation; programs; research facility; success; tenure track; ventilation

PROJECT SUMMARY This proposal requests funds to acquire Tecniplast Emerald EM500 individually ventilated caging (IVC) systems to modernize and incorporate the latest IVC technology into a shared use vivarium at Florida State University (FSU). The FSU Animal Care and Use Program is poised to experience unprecedented growth as a result of the University President’s bold and ambitious agenda to increase annual research funding from $328M to $500M by building capacity in life sciences, medical research, and health data sciences and by hiring approximately 170 new, full- time, tenure-track faculty. The open-top and microisolator caging used program-wide cannot support the anticipated growth within existing facilities. Moreover, the expansion of the FSU research enterprise will undoubtedly translate into an increase in work with immunocompromised rodents and hazardous agents, which due to the lack of appropriate engineering controls, the University is presently ill-equipped to handle. Additionally, recent consultancy studies commissioned by the FSU Office of the Vice President for Research (OVPR) have identified occupational health concerns, specifically personnel exposure to laboratory animal allergens associated with the widespread use of open-top caging. The goal of this project is to acquire six single-sided mouse racks, three double-sided mouse racks, and one single-sided rat rack for the Biomedical Research Facility (BRF) vivarium, which, in combination, will provide 1,092 cage spaces for rodents and increase the mouse cage holding capacity of the vivarium by 162%. In addition to space optimization, the IVC technology requested is expected to mitigate occupational allergen exposure risks, provide appropriate engineering controls for work with immunocompromised rodents and hazardous agents, and improve microenvironmental conditions for FSU animal resources. The operational innovation and benefits to personnel health and safety and animal welfare achieved by the success of this proposal will uniquely position FSU and LAR to meet the demands of a burgeoning research enterprise and the needs of current and future NIH-funded investigators.

项目概要 该提案要求提供资金购买 Tecniplast Emerald EM500 独立通风 笼养 (IVC) 系统实现现代化并将最新的 IVC 技术纳入共享用途 佛罗里达州立大学 (FSU) 的动物饲养场准备开展动物护理和使用计划。 由于大学校长的大胆和雄心勃勃，经历了前所未有的发展 通过生活能力建设将年度研究经费从 3.28 亿美元增加到 5 亿美元的议程 科学、医学研究和健康数据科学，并通过雇用大约 170 名新的、全职的 时间，终身教职人员无法在整个计划中使用开放式和微型隔离笼。 此外，还支持 FSU 的扩展。 毫无疑问，研究事业将转化为与以下方面的合作的增加： 免疫功能低下的啮齿动物和危险物质，由于缺乏适当的 工程控制方面，大学目前没有足够的能力来处理。 佛罗里达州立大学研究副校长办公室委托进行的咨询研究 (OVPR) 已确定职业健康问题，特别是人员接触 与开顶笼的广泛使用相关的实验动物过敏原。 本项目拟购置6个单面鼠标架、3个双面鼠标架、1个 用于生物医学研究设施 (BRF) 动物园的单面大鼠架，结合起来， 将为啮齿类动物提供1,092个笼舍空间，并增加老鼠笼的容纳能力 除了空间优化之外，IVC 技术也有望提高 162%。 为了减轻职业过敏原暴露风险，提供适当的工程控制 与免疫功能低下的啮齿动物和危险物质一起工作，并改善 FSU动物资源的微环境条件。 该项目的成功为人员健康和安全以及动物福利带来了好处 该提案将为 FSU 和 LAR 提供独特的定位，以满足新兴研究的需求 企业以及当前和未来 NIH 资助的研究人员的需求。