Modernization of Small Animal Caging for infectious disease studies at the Boise VAMC

博伊西 VAMC 用于传染病研究的小动物笼舍现代化

基本信息

批准号：
10734738
负责人：
Jay R Radke
金额：
$ 21.39万
依托单位：
IDAHO VETERANS RESEARCH / EDUCATION FDN
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10734738
关键词：
2019-nCoV Air Movements Animal Experiments Animal Husbandry Animal Model Animals Award Beds COVID-19 pandemic Cell Nucleus Clinical Communicable Diseases DNA sequencing Development Emerging Communicable Diseases Exposure to Fostering Frequencies Funding Generations Goals Hamsters Housing Human Resources Humidity Idaho Immune response Infectious Agent Laboratories Medical Medical center Modernization Mus Names Pilot Projects Reproducibility Research Research Personnel Research Project Grants Research Support Safety Scientist Site Small Business Technology Transfer Research Temperature Time Training United States Department of Veterans Affairs United States National Institutes of Health Water Water consumption animal dander biobank biological research career clinical diagnostics diagnostic assay experimental study improved innovation microorganism growth molecular diagnostics novel therapeutics pandemic disease programs research study variant detection ventilation wasting

项目摘要

PROJECT SUMMARY While static caging for husbandry of small animals is accepted by the Guide, ventilated caging has become the gold standard for small animal husbandry. Static caging results in increased temperature and humidity in the cages. This results in wet bedding materials that can foster growth of micro-organisms. As a result, increased changing of animal bedding is required to maintain sanitary living conditions. Increased frequency in cage changing has multiple detrimental effects. First, more bedding is required to house the animals and generates more bedding waste. Second, multiple cage changes per week increases the water consumption and dirty wastewater generation as cages require sanitization in hot water cage washers. Third, increased handling of animals can have negative effects on research studies. Fourth, frequent cage changing increases the exposures of VMU personnel to both animal dander and infectious agents. The goal of this project is to obtain funds to upgrade the caging at the Boise Veterans Affairs Medical Center Veterinary Medical Unit (VMU) from static caging to ventilated caging. By moving from static caging to ventilated caging the animals will be in housing that provides better air flow allowing for better control of temperature and humidity in their cages, improving not only the living conditions for the small animals but increasing the rigor and reproducibility of the experiments conducted in the VMU as well as safety of VMU personnel.

项目概要虽然《指南》接受用于饲养小动物的静态笼养，但通风笼养成为小型畜牧业的黄金标准。静态笼养会导致温度升高笼子里的湿度。这会导致垫料潮湿，从而促进微生物生长。作为一个因此，需要增加动物垫料的更换以保持卫生的生活条件。增加频繁更换笼子会产生多种有害影响。首先，需要更多的垫料来容纳动物并产生更多的床上用品废物。其次，每周多次更换笼子会增加耗水量笼子产生的脏废水需要热水笼子清洗机进行消毒。三、增加处理动物可能会对研究产生负面影响。四、频繁换笼增加 VMU 人员接触动物皮屑和传染源。该项目的目标是获得用于升级博伊西退伍军人事务医疗中心兽医医疗单位 (VMU) 笼舍的资金静态笼养改为通风笼养。通过从静态笼子转移到通风笼子，动物将被安置在笼子里提供更好的空气流通，可以更好地控制笼子内的温度和湿度，从而改善只改善小动物的生活条件，但提高实验的严谨性和可重复性以及 VMU 人员的安全。