Intravital Microscopy Core

活体显微镜核心

• 批准号: 10703082
• 负责人: Roberto Weigert
• 金额: $ 26.1万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10703082
• 关键词: Anaphase; Animal Model; Animals; CCR; Cell Cycle; Cell physiology; Data Analyses; Development; Disease; Experimental Designs; Extracellular Matrix; Human; Image; Immune system; Investigation; Malignant Neoplasms; Messenger RNA; Mission; Neoplasm Metastasis; Neutrophil Infiltration; Organ; Pathologic; Peripheral; Pharmaceutical Preparations; Physiological; Procedures; Research Personnel; Rhabdomyosarcoma; Rodent Model; Role; Skin; Squamous cell carcinoma; Time; Tissues; Transgenic Animals; Tumor Cell Invasion; Xenograft Model; cellular imaging; drug efficacy; efficacy testing; high resolution imaging; imaging approach; intravital imaging; intravital microscopy; lung cancer cell; malignant breast neoplasm; mechanical properties; melanoma; multimodality; novel; tumor; tumor initiation; tumor microenvironment; tumor progression; wound healing

Since its inception, the CCR IVM Core has been developing the following 8 projects: 1) Role of peripheral mRNAs in controlling tumor invasion and metastasis - Investigator Voula Mili (LCMB) 2) Intravital imaging of drug-induced Anaphase Catastrophe in human Lung Cancer Cells expressing Fucci-4 in Xenograft models - Investigator Ethan Dimitorvsky (Frederick National Lab) 3) Role of Smurf2 during wound healing - Investigator -Ying Zhang (LCMB) 4) Role of ASAP1 in the progression of Rhabdomyosarcomas (RBDs). - Investigator Paul Randazzo (LCMB) 5) Imaging mechanical properties of tumor microenvironment during melanoma progression - Investigator Glenn Merlino LCBG 6) Role of Trail during neutrophil infiltration in breast cancer. Investigator Stan Lipkowitz (WMB); 7) Ramiro Iglesias-Barolome (LCMB) - Role of PKI in basal squamous cell carcinoma in the skin; 8) Steven Cappell (LCBG) - Imaging cell cycle during tumor progression.

自成立以来，CCR IVM核心一直在开发以下8个项目：1）周围mRNA在控制肿瘤侵袭和转移中的作用 - 研究者Voula mili（LCMB）2）药物诱导的过后期灾难的内部想象成像在人类肺癌细胞中表达富素级的模型（Fucci -4伤口愈合过程中的蓝精神 - 研究者-Ying Zhang（LCMB）4）ASAP1在横纹肌肉瘤进展中的作用（RBD）。 - 研究人员Paul Randazzo（LCMB）5）黑色素瘤进展过程中肿瘤微环境的成像机械性能 - 研究者Glenn Merlino LCBG 6）tra迹在嗜中性粒细胞浸润在乳腺癌中的作用。研究人员Stan Lipkowitz（WMB）; 7）Ramiro Iglesias -Barolome（LCMB） - PKI在皮肤中基底鳞状细胞癌中的作用； 8）Steven Cappell（LCBG） - 肿瘤进展过程中成像细胞周期。