IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB)

预防结核分枝杆菌中心 (IMPAC-TB) 的免疫机制

• 批准号: 10691837
• 负责人: KEVIN URDAHL
• 金额: $ 921.2万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2026-09-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10691837
• 关键词: Animals; Goals; HIV; HIV Seronegativity; HIV Seropositivity; Human; Immune; Immune Evasion; Immune Targeting; Immune response; Immunity; Immunologics; Mus; Mycobacterium Infections; Mycobacterium tuberculosis; Pathway interactions; Research Activity; Research Personnel; SIV; Tissues; Tuberculosis; Tuberculosis Vaccines; design; human subject; improved; multidisciplinary; non-tuberculosis mycobacteria; nonhuman primate; programs; response; vaccine strategy; vaccine-induced immunity

The goal of this program is to establish an integrated multi-disciplinary team of highly collaborative investigators that will plan and conduct iterative, in-depth immunologic analyses of tissue-specific and systemic responses in small animals, non-human primates (NHPs), and humans to identify the key immune responses needed for protection against Mtb; identify immunologic targets that can be used to improve TB vaccine strategies. Other research activities under the program may include determining the impact of HIV/SIV and Nontuberculous Mycobacteria (NTM) infection(s) on relevant immune responses to Mtb infection or TB vaccines and identifying how bacterial immune evasion mechanisms subvert immune responses to Mtb.

该计划的目的是建立一个由高度协作的研究人员组成的综合多学科团队，该团队将对小动物，非人类灵长类动物（NHP）的组织特异性和全身反应进行迭代，深入的免疫学分析，并确定针对MTB的保护所需的关键免疫反应；确定可用于改善结核病疫苗策略的免疫靶标。该计划下的其他研究活动可能包括确定HIV/SIV和非结核分枝杆菌（NTM）感染对MTB感染或TB疫苗相关免疫反应的影响，并确定细菌免疫逃避机制如何增强对MTB的免疫反应。