Characterization of hematopoietic stem cell (HSC) and progenitor cell aging, identification of candidate age-regulated genes as targets for therapeutic intervention

造血干细胞 (HSC) 和祖细胞衰老的表征，识别候选年龄调节基因作为治疗干预的目标

• 批准号: 10688900
• 负责人: Isabel Beerman
• 金额: $ 19.62万
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10688900
• 关键词: Adult; Age; Aging; Animals; Attenuated; Autoimmunity; Automobile Driving; Biological; Biological Models; Blood; Breeding; Categories; Cell Aging; Cell Compartmentation; Cells; DNA Damage; DNA Methylation; DNA Repair; Disease; Dysmyelopoietic Syndromes; Epigenetic Process; Genes; Hematopoietic; Hematopoietic stem cells; Homeostasis; Human; Intervention; Lymphoid; Maintenance; Mus; Norway; Pathway interactions; Phenotype; Rattus norvegicus; Recording of previous events; Research; Solid; System; Therapeutic Intervention; Work; candidate identification; epigenetic regulation; experimental study; falls; hematopoietic stem cell aging; interest; leukemia; mouse model; nonhuman primate; prevent; primitive cell; regeneration potential; response; restoration; sex; stem cells; targeted treatment; therapeutic target; Adult; Age; Aging; Animals; Attenuated; Autoimmunity; Automobile Driving; Biological; Biological Models; Blood; Breeding; Categories; Cell Aging; Cell Compartmentation; Cells; DNA Damage; DNA Methylation; DNA Repair; Disease; Dysmyelopoietic Syndromes; Epigenetic Process; Genes; Hematopoietic; Hematopoietic stem cells; Homeostasis; Human; Intervention; Lymphoid; Maintenance; Mus; Norway; Pathway interactions; Phenotype; Rattus norvegicus; Recording of previous events; Research; Solid; System; Therapeutic Intervention; Work; candidate identification; epigenetic regulation; experimental study; falls; hematopoietic stem cell aging; interest; leukemia; mouse model; nonhuman primate; prevent; primitive cell; regeneration potential; response; restoration; sex; stem cells; targeted treatment; therapeutic target

The ESC Unit's focus on "Characterization of hematopoietic stem cell (HSC) and progenitor cell aging, identification of candidate age-regulated genes as targets for therapeutic intervention" has been focused on establishing a solid platform for which all experiments will be built from. The Epigenetics and Stem Cell (ESC) Unit largely uses the murine model system to study the hematopoietic stem cell (HSC) compartment and the alterations that occur during aging. The ESC unit is continuing breeding and aging murine colonies for experiments and have expanded our research to include other species of animals including Fisher (F-344), Fisher X BN (F344BN) and Bronwn Norway (BN) rats and non-human primates. We have also begun exploring epigenetic aspects of human primitive cell aging We are currently working on projects that fall into six main research categories with aging HSCs as the primary cells of interest: Epigenetic regulation, Reprogramming, Sex-specific aging phenotypes, Extrinsic Contribution, Interventions, and Additional Model systems.

ESC单元的重点是“造血干细胞（HSC）和祖细胞衰老的表征，鉴定候选年龄调节基因作为治疗干预的靶标”一直集中在建立一个坚实的平台上，以为所有实验建立所有实验。 表观遗传学和干细胞（ESC）单元在很大程度上使用鼠模型系统研究造血干细胞（HSC）室以及衰老过程中发生的变化。 ESC单元正在继续进行实验的繁殖和老化的鼠菌落，并扩大了我们的研究，包括费舍尔（F-344），Fisher X BN（F3444亿）和Bronwn Norway（BN）大鼠和非人类灵长类动物等其他动物。 我们还开始探索人类原始细胞衰老的表观遗传方面 我们目前正在研究，这些项目属于六个主要的研究类别，其中HSC是感兴趣的主要细胞：表观遗传调节，重编程，特定性别的老化表型，外部贡献，干预措施和其他模型系统。