A Multicomponent Intervention to Increase HIV Risk Perceptions and PrEPInitiation among Black Men Who Have Sex With Men

提高男男性行为黑人的艾滋病毒风险认知和预防准备的多成分干预措施

• 批准号: 10689428
• 负责人: Derek Tramel Dangerfield II
• 金额: $ 18.41万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-24 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10689428
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Address; Age; Appointments and Schedules; Award; Baltimore; Behavior; Behavioral; California; Cessation of life; Cities; Clinical; Communities; Data; Data Collection; Development; Discrimination; Disease susceptibility; Doctor of Philosophy; Educational workshop; Elements; Evaluation; Exposure to; Focus Groups; Fostering; Future; Guidelines; HIV; HIV Infections; HIV Seronegativity; HIV risk; HIV/STD; Health; Health Personnel; Health Promotion; Healthcare; Incidence; Infection; Insurance; Insurance Coverage; Intervention; Judgment; Lead; Life; Life Cycle Stages; Maryland; Medical; Mentors; Mentorship; Methods; Modeling; Opioid; Patients; Perception; Phase; Population; Predisposition; Prevention education; Prevention strategy; Principal Investigator; Procedures; Provider; Public Health Schools; Recording of previous events; Reduce health disparities; Research; Research Methodology; Research Personnel; Research Training; Risk; Risk Behaviors; Role; Sampling; School Nursing; Scientist; Self Efficacy; Services; Sex Behavior; Statistical Data Interpretation; Techniques; Technology; Telemedicine; Testing; Time; TimeLine; Training; Universities; Work; acceptability and feasibility; base; behavioral/social science; black men who have sex with men; career; cohort; data standards; design; diaries; efficacy trial; experience; generation difference; health belief; high risk; implementation science; improved; innovation; interest; medical schools; men who have sex with men; motivational enhancement therapy; multi-component intervention; peer; peer support; pilot test; pre-exposure prophylaxis; preference; prevent; research and development; risk perception; sexual risk behavior; skills; smartphone Application; social stigma; theories; therapy design; training opportunity; transmission process; uptake; willingness

PROJECT SUMMARY/ABSTRACT Tragically, HIV infections among Black men who have sex with men (BMSM) in the U.S. persist. Despite the availability and interest in pre-exposure prophylaxis (PrEP), effective uptake among BMSM remains low. It is imperative to mitigate barriers to PrEP initiation among this group, which could require HIV interventions that incorporate behavioral, biomedical, and structural strategies. The proposed theory-guided, multi-component intervention is designed to enhance HIV risk perceptions and increase PrEP initiation among BMSM in Baltimore City, using an existing mobile smartphone application along with peer change agents to record and review sexual risk behaviors and encourage PrEP initiation. The proposed research and training plan in this Mentored Research Scientist Developmental Award (K01) proposal will provide the principal investigator, Derek T. Dangerfield II, PhD, with the skills needed in intervention design to develop into a productive, independent investigator. The research and training aims proposed address a critical gap in HIV prevention; it is well established that extant work has failed to substantially lower infections among BMSM throughout the U.S. To strategically advance these training aims, this K01 proposal is crafted to facilitate professional development and research capacities as a rising independent investigator. Targeted course work, didactic workshops, and in-depth mentorship from experts in the domains of clinical intervention design, life course theoretical approaches to health, and statistical analysis are incorporated to facilitate hands-on opportunities to apply newly developed skills. The combined use of technology, peers, and PrEP leverages existing relevant prevention strategies for a multi-component intervention. This research is innovative and timely as it responds to federal and academic calls for carefully considerate, interdisciplinary interventions to reduce HIV incidence among priority populations. The aims of this proposal incorporate qualitative and quantitative research methods to explore the preferences of the components of an intervention to increase PrEP initiation among the population. This research has implications for understanding whether the methods used in this intervention can be applied in clinical settings or can be applied in peer-based settings to circumvent the barriers of traditional healthcare engagement. Dr. Dangerfield will be primarily mentored by senior investigator Jason Farley, PhD, MPH, ANP-BC, FAAN at the Johns Hopkins School of Nursing, with additional mentoring from Drs. Chris Beyrer (Johns Hopkins Bloomberg School of Public Health), Ricky Bluthenthal (University of Southern California Keck School of Medicine), and Renata Arrington-Sanders (Johns Hopkins School of Medicine). Through research and didactic mentoring and training, Dr. Dangerfield will build upon his expertise in behavioral social science to develop a successful career in designing high-impact, multicomponent clinical interventions and reduce health disparities.

项目概要/摘要 可悲的是，美国男男性行为黑人 (BMSM) 中的艾滋病毒感染持续存在。 尽管对暴露前预防 (PrEP) 的可用性和兴趣，BMSM 的有效采用 仍然很低。必须消除该群体启动 PrEP 的障碍，这可能需要 HIV 结合行为、生物医学和结构策略的干预措施。所提出的理论指导， 多成分干预旨在增强艾滋病毒风险认知并增加人群的 PrEP 启动 巴尔的摩市的 BMSM 使用现有的移动智能手机应用程序以及同行变革代理来 记录和审查性风险行为并鼓励启动 PrEP。拟议的研究和培训 本指导研究科学家发展奖 (K01) 提案中的计划将提供主要内容 研究员 Derek T. Dangerfield II 博士，拥有干预设计所需的技能，可发展为 富有成效的、独立的调查员。拟议的研究和培训目标旨在解决艾滋病毒方面的关键差距 预防;众所周知，现有工作未能显着降低 BMSM 中的感染率 为了战略性地推进这些培训目标，本 K01 提案旨在促进 作为一个正在崛起的独立调查员的专业发展和研究能力。有针对性的课程作业， 教学研讨会以及临床干预设计、生活领域专家的深入指导 课程结合了健康理论方法和统计分析，以方便实践 应用新开发的技能的机会。技术、同行和 PrEP 杠杆的结合使用 现有的多成分干预的相关预防策略。这项研究具有创新性和 及时响应联邦和学术界的呼吁，要求采取深思熟虑的跨学科干预措施 降低重点人群的艾滋病毒发病率。该提案的目标包括定性和 定量研究方法探索干预措施组成部分的偏好，以增加 在人群中启动 PrEP。这项研究对于理解这些方法是否 此干预中使用的方法可以应用于临床环境，也可以应用于基于同伴的环境 规避传统医疗保健参与的障碍。 Dangerfield 博士将主要接受以下人士的指导： 约翰霍普金斯大学护理学院高级研究员 Jason Farley，博士、公共卫生硕士、ANP-BC、FAAN 博士的额外指导。 Chris Beyrer（约翰霍普金斯大学彭博公共卫生学院），Ricky Bluthenthal（南加州大学凯克医学院）和 Renata Arrington-Sanders（约翰斯 霍普金斯医学院）。通过研究、教学指导和培训，丹格菲尔德博士将建立 凭借他在行为社会科学方面的专业知识，在设计高影响力方面取得了成功的职业生涯， 多成分临床干预措施并减少健康差距。

项目成果

Conducting Virtual, Synchronous Focus Groups Among Black Sexual Minority Men: Qualitative Study.

• DOI: 10.2196/22980
• 发表时间: 2021-02-08
• 期刊: JMIR public health and surveillance
• 影响因子: 8.5
• 作者: Dangerfield Ii DT;Wylie C;Anderson JN
• 通讯作者: Anderson JN

Community engagement and linkage to care efforts by peer community-health workers to increase PrEP uptake among sexual minority men.

• DOI: 10.1111/phn.12887
• 发表时间: 2021-09
• 期刊: Public health nursing (Boston, Mass.)
• 作者: Farley JE;Dangerfield DT 2nd;LaRicci J;Sacamano P;Heidari O;Lowensen K;Jennings JM;Tobin KE
• 通讯作者: Tobin KE