Transdiagnostic Associations Across Developmental Disorders

发育障碍的跨诊断关联

基本信息

批准号：
10701008
负责人：
ELENA L GRIGORENKO
金额：
$ 65.87万
依托单位：
UNIVERSITY OF HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-09 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10701008
关键词：
14 year old Address Adolescent Adopted Africa Africa South of the Sahara African Area Asia Attitude Behavior Belief Biological Blindness Botswana Brain Caregivers Caring Catchment Area Characteristics Child Child Health Church Classification Clinical Communities Community Services Country Data Data Set Dedications Detection Development Developmental Disabilities Diagnosis Diagnostic Differential Diagnosis Disease EEF1A2 gene Electroencephalography Ensure Etiology Event Family Fathers Focus Groups Funding Genetic Markers Genome Ghana Goals Health Health Services Health education Home Hospital Administration Hospitals Household Income Individual Individuality Intellectual functioning disability Interview Kenya Link Literature Malawi Mission Monitor Mothers Namibia Nigerian Pacifiers Pathway Analysis Pathway interactions Perception Personal Satisfaction Persons Phenotype Policy Maker Population Prevalence Province Public Health Punishment Radial Research Research Personnel Resources Rural Rural Community Sampling Schools Services Siblings Social Environment Source Structure Surveys Sustainable Development Tanzania Trust Typology United Nations United States National Institutes of Health Universities Witchcraft Work Youth Zambia Zimbabwe aged burden of illness child services childhood epilepsy developmental disease disability dynamic system early childhood functional near infrared spectroscopy girls health record hearing impairment human subject improved informant low and middle-income countries member neurophysiology physically handicapped policy recommendation proband recruit remediation rural setting social stigma

项目摘要

SUMMARY The Global Burden of Disease (GBD) data of 2017 revealed that worldwide 291.2 million (11.2%) of 2.6 billion children and adolescents were estimated to have one of four developmental disabilities (childhood epilepsy, intellectual disability, and vision loss and hearing loss), which is an increase of more than double since 2004. Sub-Saharan Africa (SSA), along with South Asia, hosts the overwhelming majority (94.5%) of these children. These children, especially in SSA, are severely underrepresented in the relevant literature. The proposed work is intended to contribute to improving the representation of children and youth from SSA in the scientific literature. The overarching objective of this work is to identify and characterize children/youth (aged 3-18) with developmental disabilities (DD) growing up in rural Zambia. The proposed work is structured around three unique SA. SA1 pertains to the ascertainment of a large sample of children/youth with DD and their matched siblings (total n = 4,000). SA2 addresses the characterization of this sample of children to identify and classify the etiology and potential treatment of their DD. SA3 intends to document the services that are currently accessed by children/youth with DD, and to ascertain community perceptions of DD, to advise on what services are available, accessed, or needed. Collectively, SA1-3 will generate a unique multi-level (social context—behavior—brain—genome) dataset presenting a range of manifestations and causal pathways to DD in rural Zambia in particular and in SSA in general.

概括 2017 年全球疾病负担 (GBD) 数据显示，全球 26 亿人中有 2.912 亿人 (11.2%) 据估计，儿童和青少年患有四种发育障碍之一（儿童癫痫、智力障碍、视力丧失和听力丧失），自 2004 年以来增加了一倍多。撒哈拉以南非洲 (SSA) 以及南亚收容了绝大多数 (94.5%) 的儿童。这些儿童，尤其是 SSA 儿童，在相关文献中的代表性严重不足。旨在促进提高 SSA 儿童和青少年在科学领域的代表性这项工作的首要目标是识别和描述儿童/青少年（3-18 岁）的特征。拟议的工作围绕三个方面展开。独特的 SA1 涉及确定大量患有 DD 的儿童/青少年及其匹配的样本。 SA2 描述了该儿童样本的特征，以进行识别和分类。其 DD 的病因和潜在治疗方法 SA3 旨在记录当前提供的服务。患有 DD 的儿童/青少年访问，并确定社区对 DD 的看法，就什么问题提出建议服务可用、可访问或需要总的来说，SA1-3 将生成一个独特的多层次（社交。背景—行为—大脑—基因组）数据集呈现了一系列 DD 的表现和因果路径特别是在赞比亚农村地区和整个撒哈拉以南非洲地区。