Neurosys - Neuroinformatics for Neural Systems

Neurosys - 神经系统的神经信息学

基本信息

批准号：
7315478
负责人：
Gwen Ann Jacobs
金额：
$ 51.01万
依托单位：
MONTANA STATE UNIVERSITY - BOZEMAN
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-09-01 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7315478
关键词：
Amplifiers Brain Categories Clinical Collaborations Collection Communities Computer software Controlled Vocabulary Data Data Analyses Data Collection Data Files Data Set Databases Development Devices Documentation Electron Microscope Environment Extensible Markup Language Feedback Functional disorder Funding Goals Grant Human Human Resources Informatics Institution Internet Laboratories Metadata Methods Modeling Nervous system structure Neurons Neurosciences Neurosciences Research Online Systems Phase Physiological Process Publications Publishing Research Research Personnel Resources Secure Series Site Source Standardization Suggestion System Testing Translating Validation Vocabulary Work base computerized data processing data acquisition data management data modeling digital distributed data interoperability neuroinformatics open source peer prevent programs prototype relating to nervous system simulation tool

项目摘要

DESCRIPTION (provided by applicant): Several major technological barriers obstruct progress toward answering fundamental questions in basic and clinical neuroscience. One principal barrier is the lack of effective mechanisms for neuroscientists and clinicians to share their data with colleagues at other institutions, and to gain access to the vast resources of data that are distributed throughout the neuroscience research community. This barrier must be removed by the development of more powerful and accessible informatics tools to enable our exploration of the development, structural organization and dysfunction of our nervous system. The problems contributing to this 'informatics' barrier can be subdivided into two general categories: technical problems which limit the capabilities of existing informatics tools, and practical problems which prevent the use of those tools by the general research community. Through funding from a Phase I Human Brain Project grant, we have developed a prototype database environment that solves several of the most significant technical and practical problems. This software environment, called NeuroSys, enables neuroscience researchers to construct, maintain and extend their own in-lab databases, enhances their ability to share data and analysis tools with their collaborators at different sites, and provides an execution environment where query results on their data can be sent directly into an expandable list of advanced data analysis and simulation tools. The general goals of this project are to extend the capabilities and general utility of this prototype system, to refine the system based on intensive beta testing, and to release NeuroSys to the general scientific community.

描述（由申请人提供）：几个主要的技术障碍阻碍了回答基础和临床神经科学基本问题的进展。一个主要障碍是神经科学家和临床医生缺乏与其他机构的同事共享数据以及获取分布在整个神经科学研究界的大量数据资源的有效机制。必须通过开发更强大、更易于使用的信息学工具来消除这一障碍，使我们能够探索神经系统的发育、结构组织和功能障碍。造成这种“信息学”障碍的问题可以分为两大类：限制现有信息学工具能力的技术问题，以及阻止一般研究界使用这些工具的实际问题。通过第一阶段人脑项目拨款的资助，我们开发了一个原型数据库环境，可以解决几个最重要的技术和实际问题。这个名为 NeuroSys 的软件环境使神经科学研究人员能够构建、维护和扩展他们自己的实验室数据库，增强他们与不同地点的合作者共享数据和分析工具的能力，并提供一个执行环境，在其中查询数据结果可以直接发送到可扩展的高级数据分析和模拟工具列表中。该项目的总体目标是扩展该原型系统的功能和通用实用性，基于密集的 beta 测试来完善该系统，并向一般科学界发布 NeuroSys。