Developing an intervention targeting sleep disturbances among minority bereaved individuals

针对少数民族丧亲者的睡眠障碍制定干预措施

• 批准号: 10684220
• 负责人: Diana Andrea Chirinos
• 金额: $ 16.19万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10684220
• 关键词: Acute; Address; Adherence; Adult; Behavior Therapy; Bereavement; Biological; Cardiovascular Diseases; Cardiovascular system; Cessation of life; Clinical Trials; Cognitive Therapy; Collection; Data; Development; Development Plans; Disease; Dropout; Emotional; Ensure; Environment; Event; Evidence based intervention; Faculty; Feedback; Five-Year Plans; Focus Groups; Funding; Future; Goals; Grant; Grief reaction; Individual; Inflammation; Inflammatory; Institution; Intervention; K-Series Research Career Programs; Knowledge; Longitudinal Studies; Measures; Mental Health; Mentors; Methodology; Minority; Myocardial Infarction; Outcome; Participant; Pittsburgh Sleep Quality Index; Population; Positioning Attribute; Quality of life; Randomized, Controlled Trials; Research; Research Personnel; Research Project Grants; Residual state; Severities; Sleep; Sleep disturbances; Sleeplessness; Spouses; Stroke; Structure; Surveys; Symptoms; Testing; Time; Training; Training Activity; United States National Institutes of Health; Universities; Vulnerable Populations; Writing; behavior test; cardiovascular disorder risk; career; career development; depressive symptoms; efficacy testing; improved; improvement on sleep; indexing; medical schools; mortality risk; physical conditioning; post intervention; preference; prevent; primary outcome; psychological distress; recruit; retention rate; secondary outcome; skills; therapy design; therapy development

This five-year plan for a K01 Mentored Career Development Award to Promote Faculty Diversity will equip Dr. Diana Chirinos Medina with the essential knowledge and skills to help launch her career as an independent investigator specializing in the development of evidence-based interventions aimed at reducing cardiovascular disease (CVD) risk among vulnerable populations. Career Development and Training Activities: A carefully drafted career development plan will supplement Dr. Chirinos Medina's expertise in observational CVD studies and allow for an expansion of her skillset as an interventionist. The structure established by well-defined training goals will ensure her career development and facilitate her transition to independence. The training goals are: 1) to develop expertise in the collection and interpretation of objective sleep measures; 2) to gain a deeper understanding of sleep disturbance and other quality of life issues in bereavement; 3) to acquire the necessary skills to create and test behavioral interventions; 4) to strengthen the candidate's training in the inflammatory mechanisms underlying CVD risk; and 5) to continue to develop grant writing skills and successfully submit an R-level application to the National Institutes of Health (NIH). The candidate will receive guidance from experts in their respective fields (Drs. Carnethon, Ong, Fagundes and Miller) and take full advantage of the strong institutional support and environment at Northwestern University Feinberg School of Medicine. Research Plan: In spite of the rates of sleep disturbance in bereavement and its detrimental impact on mental and physical health, no study to date has examined the effects of a direct intervention on sleep disturbance in this population. Therefore, it is unknown whether interventions aimed at improving sleep in bereavement are feasible or effective. The proposed research project will focus on developing a targeted behavioral intervention for sleep disturbance among bereaved individuals and testing it for feasibility, acceptability and preliminary effects. The intervention will be based on existing behavioral treatments for sleep disturbance, but will tailor its components to address the specific needs of the bereaved population. To identify opportunities for targeting treatment and potential barriers to intervention, Dr. Chirinos Medina will recruit bereaved individuals with sleep disturbance who will participate in focus groups (Aim 1). Based on the feedback from focus groups, she will iteratively develop and optimize an intervention for sleep disturbance in bereavement (Aim 2) and test it for acceptability, feasibility, and preliminary effects (Aim 3). The primary outcome will be sleep disturbance. Secondary outcomes will include quality of life and inflammation. At the end of this research, the candidate will be in an ideal position to develop interventions for sleep disturbance in bereavement and other populations vulnerable to CVD. In addition, this study will lay the groundwork for a larger trial to test the efficacy of the targeted intervention in decreasing sleep disturbance and overall CVD risk among bereaved adults.

这项为促进教师多样性的K01指导职业发展奖的五年计划将配备 Diana Chirinos Medina博士具有基本知识和技能，以帮助她成为独立的职业 专门研究旨在减少心血管的循证干预措施的研究者 脆弱人群中的疾病（CVD）风险。职业发展和培训活动：仔细的 起草的职业发展计划将补充Chirinos Medina博士的观察性CVD研究专业知识 并允许扩大她作为干预主义者的技能。定义明确建立的结构 培训目标将确保她的职业发展并促进她向独立的过渡。培训 目标是：1）在收集和解释客观睡眠措施方面发展专业知识； 2）获得 在丧亲中，更深入地了解睡眠障碍和其他生活质量问题； 3）获取 创建和测试行为干预措施的必要技能； 4）加强候选人在 CVD风险的炎症机制； 5）继续发展授予写作技巧和 成功地向美国国立卫生研究院（NIH）提交R级申请。候选人将收到 来自各自领域的专家（Carnethon，Ong，Fagundes和Miller博士）的指导 西北大学Feinberg School的强大机构支持和环境的优势 药品。研究计划：尽管丧亲及其不利影响的睡眠障碍率 关于心理和身体健康，迄今为止尚无研究检查直接干预对睡眠的影响 这个人群的干扰。因此，尚不清楚旨在改善睡眠的干预措施是否 丧亲是可行的或有效的。拟议的研究项目将着重于开发针对性的 丧亲个体中睡眠干扰的行为干预并为可行性进行测试， 可接受性和初步影响。干预将基于现有的睡眠行为治疗 干扰，但会量身定制其组成部分，以满足丧亲人口的特定需求。识别 Chirinos Medina博士将招募靶向治疗和潜在障碍的机会 失去睡眠障碍的人将参加焦点小组（AIM 1）。基于 焦点小组的反馈，她将迭代地开发并优化干预睡眠干扰的干预措施 丧亲（AIM 2）并测试其可接受性，可行性和初步影响（AIM 3）。主要 结果将是睡眠障碍。次要结果将包括生活质量和炎症。在最后 在这项研究中，候选人将有理想的位置，以制定干预措施以进行睡眠障碍 丧亲和其他容易受到CVD的人群。此外，这项研究将为 更大的试验以测试目标干预措施减少睡眠障碍和总体CVD风险的功效 在失去亲人的成年人中。

项目成果

The role of behavioral science in addressing cardiovascular health disparities: A narrative review of efforts, challenges, and future directions.

• DOI: 10.1037/hea0001191
• 发表时间: 2022-10
• 期刊: HEALTH PSYCHOLOGY
• 影响因子: 4.2
• 作者: Chirinos, Diana A.;Vargas, Emily;Kamsickas, Lisa;Carnethon, Mercedes
• 通讯作者: Carnethon, Mercedes

Depressive Symptom Subgroups and Their Association with Prevalent and Incident Cardiovascular Risk Factors in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.

年轻人冠状动脉风险发展 (CARDIA) 研究中抑郁症状亚组及其与流行和事件心血管危险因素的关联。

• DOI: 10.1007/s12529-022-10144-z
• 发表时间: 2023
• 期刊: International journal of behavioral medicine
• 影响因子: 2.7
• 作者: Chirinos,DianaA;Kershaw,KiarriN;Allen,NorrinaB;Carroll,AllisonJ;Lewis,TenéT;Schreiner,PamelaJ;Lewis,CoraE;Kiefe,CatarinaI;Mezuk,Briana;Carnethon,MercedesR
• 通讯作者: Carnethon,MercedesR

Association of Exposure to Abuse, Nurture, and Household Organization in Childhood With 4 Cardiovascular Disease Risks Factors Among Participants in the CARDIA Study.

• DOI: 10.1161/jaha.121.023244
• 发表时间: 2022-05-03
• 期刊: JOURNAL OF THE AMERICAN HEART ASSOCIATION
• 影响因子: 5.4
• 作者: Aguayo, Liliana;Chirinos, Diana A.;Heard-Garris, Nia;Wong, Mandy;Davis, Matthew M.;Merkin, Sharon Stein;Seeman, Teresa;Kershaw, Kiarri N.
• 通讯作者: Kershaw, Kiarri N.