GODDESS (Gathering Online for Dialogue and Discussion to Enhance Social Support): Engaging young African American women in a virtual group app to address alcohol misuse, sexual risk, and PrEP in NC

GODDESS（在线聚集进行对话和讨论，以加强社会支持）：让年轻的非裔美国女性参与虚拟团体应用程序，以解决北卡罗来纳州的酒精滥用、性风险和 PrEP 问题

• 批准号: 10684239
• 负责人: Felicia Amira Browne
• 金额: $ 61.49万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10684239
• 关键词: AIDS prevention; Address; Adoption; Affect; African American; African American population; Alcohol consumption; Alcohols; Area; Asian; Behavior Therapy; Biological; Biological Testing; COVID-19; COVID-19 morbidity; COVID-19 risk; Cellular Phone; Centers for Disease Control and Prevention (U.S.); Classification; Collaborations; Communities; County; Coupled; Data; Data Analytics; Disparity; Drug usage; Enrollment; Epidemic; Evidence based intervention; Feedback; Focus Groups; Goals; HIV; HIV Seronegativity; HIV diagnosis; HIV/AIDS; Health; Heavy Drinking; Human immunodeficiency virus test; Impairment; Incidence; Individual; Intervention; Interview; Measures; Methods; Modification; North Carolina; Outcome; Outcome Assessment; Participant; Patient Self-Report; Persons; Population; Populations at Risk; Prevention; Process; Public Health; Reduce health disparities; Research; Research Activity; Research Priority; Resources; Risk; Risk Reduction; Sexually Transmitted Diseases; Social support; Support Groups; Surveys; Tablets; Technology; Testing; Time; United States National Institutes of Health; Unsafe Sex; Violence; Woman; Work; aged; alcohol and other drug; alcohol misuse; arm; biobehavior; cost; critical period; efficacy evaluation; epidemiologic data; evidence base; experience; implementation outcomes; innovation; intervention delivery; mHealth; mortality; multi-racial; peer support; pre-exposure prophylaxis; prevent; prevention service; randomized trial; reduced alcohol use; research study; response; satisfaction; service providers; sex; uptake; violence prevention; virtual; virtual group; young woman

PROJECT SUMMARY/ABSTRACT The intersection between alcohol and other drug (AOD) use among young African American women at risk for HIV is a public health issue. Recent epidemiological data highlight increases in alcohol misuse among young African American women, especially since COVID-19. These issues are coupled with persistent disparities in HIV and other sexually transmitted infections (STIs) for young African American women. Eliminating persistent disparities in HIV acquisition is key to ending the HIV epidemic, particularly in the U.S. South. Consequently, there is a critical need to decrease alcohol use and impaired sex and to increase pre-exposure prophylaxis (PrEP) uptake as prevention for this key population. The proposed study builds on decades of research of a best-evidence woman-focused intervention, including collaboration with health departments to address AOD use, sexual risk, and violence prevention. Most recently, the study team found the delivery of the intervention via mobile health (mHealth) had findings comparable with face-to-face delivery, with reduced odds of heavy alcohol use and impaired sex, suggesting that scalability via mHealth is a viable option. The next logical step is to add and test a virtual group component, as recent participant feedback across several studies with African American women in North Carolina has shown additional group engagement and support is highly desired. Consequently, in response to RFA-AA-21-016: HIV Prevention and Alcohol, this application addresses the following specific aims: Aim 1. To modify an evidence-based mHealth AOD use and sexual risk reduction intervention to include a virtual group component and information about PrEP for utilization. Initial research activities include focus group discussions with 24 African American young women who misuse alcohol and 16 service providers, as well as pretesting of the virtual group component. This brief iterative process will include modifications and refinements based on content (PrEP) and technology (from tablet to smartphone) and will include review from our Community Collaborative Board. Aim 2. To test the modified mHealth intervention (with the group component) relative to the mHealth intervention in a two-arm randomized trial with young African American women (aged 18 to 30) who misuse alcohol. A total of 500 participants who are HIV-negative who engage in heavy alcohol use will be enrolled across two North Carolina counties and referred to their local health departments for PrEP. Primary biobehavioral outcomes assessed will include reduced alcohol use (self-reported and biological, including PEth), increased PrEP uptake (self-reported and biological), and reduced sexual risk (self-reported condomless sex and impaired sex and biological testing for HIV/STIs) at 3-, 6-, 9-, and 12-month follow-ups. Aim 3. To assess acceptability, adoption, and cost of the virtual group component as a strategy to increase engagement with the mHealth intervention and PrEP utilization. Acceptability will be assessed via satisfaction surveys and post-study interviews, adoption via data analytics measuring engagement in the group and examined as a meditator of intervention outcomes, and cost via data collected about time and resources of implementing the group component.

项目摘要/摘要 在非洲裔美国妇女中，酒精与其他药物（AOD）使用之间的交集 艾滋病毒的风险是一个公共卫生问题。最近的流行病学数据突出了酒精滥用的增加 在年轻的非裔美国妇女中，特别是自19岁以来。这些问题与 艾滋病毒和其他性传播感染（性传播感染）的持续差异 女性。消除艾滋病毒收购中的持续差异是结束艾滋病毒流行的关键，尤其是在 美国南方。因此，迫切需要减少酒精使用和损害性行为以及 增加暴露前预防（PREP）吸收作为该关键人群的预防。 拟议的研究是基于数十年来对以女性为中心的最佳证据的研究， 包括与卫生部门合作以解决AOD使用，性风险和预防暴力。 最近，研究小组发现通过移动健康（MHealth）进行干预的提供结果 与面对面的交付相当，减少了大量酒精饮酒和性别受损的几率 通过MHealth的可扩展性是一个可行的选择。下一个逻辑步骤是添加和测试虚拟组 组成部分，作为最近与北部非裔美国妇女进行的几项研究的参与者反馈 卡罗来纳州表明了额外的小组参与和支持。因此，回应 到RFA-AA-21-016：预防艾滋病毒和酒精，该申请涉及以下具体目的： 目的1。修改基于证据的MHealth AOD使用和减少性风险干预措施 包括一个虚拟组组件和有关利用准备的信息。最初的研究活动 包括与24名滥用酒精和16名服务的非裔美国人年轻妇女的焦点小组讨论 提供者以及虚拟组组件的预测试。这个简短的迭代过程将包括 基于内容（准备）和技术（从平板电脑到智能手机）的修改和改进，将 包括我们社区合作委员会的评论。 目的2。用于测试相对于MHealth的修改后的MHealth干预措施（组组件） 与年轻的非洲裔美国妇女（18至30岁）进行两臂随机试验的干预 滥用酒精。共有500名艾滋病毒阴性的参与者将是大量饮酒的参与者 在北卡罗来纳州的两个县招收，并转交给其当地卫生部门进行PreP。基本的 评估的生物行为结局将包括减少酒精的使用（自我报告和生物学，包括 Peth），增加的预期吸收（自我报告和生物学），并降低了性风险（自我报告 3，6-，9和12个月的随访，无避孕套的性别和性别和生物学测试。 目的3。评估虚拟组组件的可接受性，采用和成本作为一种策略 增加参与MHealth干预和预备利用。可接受性将被评估 通过满意度调查和研究后访谈，通过数据分析来衡量参与 小组并被检查为干预结果的冥想者，并通过收集时间和时间的数据成本 实施组组件的资源。