Urban rat exposure and pediatric asthma

城市老鼠暴露与小儿哮喘

• 批准号: 10723612
• 负责人: Marieke Hilarides Rosenbaum
• 金额: $ 16.67万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10723612
• 关键词: Age; Allergens; Allergic; Allergic Disease; Asthma; Award; Binding; Binding Proteins; Boston; Child; Childhood; Childhood Asthma; Chronic Disease; Cities; Clinical Research; Clinical Trials; Collaborations; Commerce; Communities; Data; Disease; Doctor of Philosophy; Ecology; Enrollment; Environment; Environmental Health; Epidemiology; Exposure to; Faculty; Funding; Goals; Health; Home; Home environment; Hospitalization; House Dust; House mice; Housing; Human; IgE; Incidence; Individual; Institution; Intervention; Intervention Trial; Investigation; Learning; Measures; Mediating; Medical; Mentors; Modeling; Morbidity - disease rate; Mus; National Heart, Lung, and Blood Institute; National Institute of Environmental Health Sciences; Patient Self-Report; Pheromone; Play; Population Dynamics; Prevention Measures; Prevention strategy; Primary Prevention; Prospective cohort; Protein Secretion; Public Health; Rattus; Recording of previous events; Research; Resources; Restaurants; Rodent; Role; Sampling; Schools; Scientist; Services; Severities; Sleep; Statistical Methods; Techniques; Testing; Time; Training; Training Programs; Translational Research; Translations; United States National Institutes of Health; Universities; Urine; Veterinarians; Veterinary Medicine; Visit; Wild Animals; Work; Youth; career; career development; clinical investigation; clinical translation; cohort; community engagement; data to knowledge; density; design; educational atmosphere; environmental allergen; indexing; inner city; interest; mouse allergen; novel; particle; preventive intervention; primary outcome; school environment; skills; sociodemographic variables; statistics; therapy design; trial design; urban children; urban school; urban setting

Project Summary/Abstract Research: Asthma is the most common chronic disease of children living in urban centers, and exposure to rat allergen can trigger asthma in children who are sensitized. The goal of this award is to evaluate the relationship between rat exposure and asthma severity in children using novel techniques to estimate rat exposure, including ecological studies of rat population dynamics and publicly available rat-related 311 complaint calls, around the home and school environment. Established cohorts of inner-city children enrolled in the School Inner-City Asthma Study (SICAS) and Environmental Assessment of Sleep in Youth (EASY) study (PI, Dr. Wanda Phipatanakul) will be used to study the impact of rat exposure on pediatric asthma severity. This study is unique and novel because it will be the first to evaluate the relationship between rat population dynamics on asthma severity. Results may lead to interventional trials designed to reduce commensal rodent abundance as a primary prevention measure to reduce exposure to the allergens they produce. Career Development: Dr. Marieke Rosenbaum is a veterinarian and public health scientist who seeks to integrate clinical research and veterinary medicine to design interventions that reduce the negative impact of urban peri-domestic wild animals on human health. Over the course of this award, Dr. Rosenbaum will gain important human clinical research skills, learn advanced statistics and modeling, and explore community engagement as the three pillars of her K08 training program. The proposed research and Dr. Rosenbaum’s career trajectory closely align with NIEHS 2018-2023 strategic themes 1 (Advance Environmental Health Science) and 2 (Promoting Translation – Data to Knowledge to Action) by opening a new line of transdisciplinary investigation about the urban environment, rat exposure, and pediatric asthma. Environment: Dr. Rosenbaum will be mentored by Dr. Phipatanakul, an expert in epidemiology, clinical trials, and clinical investigation in asthma and allergic diseases. Her team of advisors include Jon Runstadler (DVM, PhD), Jessica Leibler (DrPH, MS), and Janis Breeze (MPH), who together with the primary mentor have committed their time, resources, and expertise to facilitate Dr. Rosenbaum’s career development and successful completion of the proposed project. During this award period, Dr. Rosenbaum will complete course work and training at Tufts University, Boston University, and Harvard University, and she will be supported by the Tufts University Clinical Translational Science Institute, which offers career development training for junior faculty. The academic environment created by the mentor and institutions and their affiliates provides an optimal environment for learning and collaborating specific to the proposed research and training.

项目概要/摘要 研究：哮喘是城市中心儿童最常见的慢性疾病，与老鼠接触 过敏原可引发过敏儿童哮喘。该奖项的目的是评估两者之间的关系。 使用新技术来估计大鼠暴露，包括大鼠暴露与儿童哮喘严重程度之间的关系 老鼠种群动态的生态研究和公开的与老鼠相关的311投诉电话，围绕 就读于内城学校的已建立的内城儿童群体。 哮喘研究 (SICAS) 和青少年睡眠环境评估 (EASY) 研究（PI，Wanda 博士） Phipatanakul）将用于研究大鼠暴露对儿童哮喘严重程度的影响。 之所以新颖，是因为它将是第一个评估大鼠种群动态与哮喘之间关系的项目 结果可能会导致旨在减少共生啮齿动物丰度的干预试验作为主要手段。 减少接触其产生的过敏原的预防措施。 职业发展：Marieke Rosenbaum 博士是一位兽医和公共卫生科学家，致力于 整合临床研究和兽医学来设计干预措施，以减少负面影响 在此过程中，罗森鲍姆博士将获得城市周边野生动物对人类健康的影响。 重要的人类临床研究技能，学习先进的统计和建模，并探索社区 参与作为她的 K08 培训计划的三大支柱 拟议的研究和 Rosenbaum 博士的研究。 职业轨迹与 NIEHS 2018-2023 战略主题 1（推进环境健康 科学）和 2（促进翻译——从数据到知识到行动），开辟一条新的跨学科路线 关于城市环境、老鼠暴露和小儿哮喘的调查。 环境：Rosenbaum 博士将接受流行病学、临床试验、 她的顾问团队包括 Jon Runstadler（DVM， Ph.D）、Jessica Leibler（PH 博士、MS）和 Janis Breeze（MPH），他们与主要导师一起 投入时间、资源和专业知识来促进罗森鲍姆博士的职业发展和成功 在此奖励期间，罗森鲍姆博士将完成课程作业并完成所提议的项目。 在塔夫茨大学、波士顿大学和哈佛大学接受培训，她将得到塔夫茨大学的支持 大学临床转化科学研究所，为初级教师提供职业发展培训。 导师和机构及其附属机构创造的学术环境提供了最佳环境 针对拟议的研究和培训的学习和合作。