Asian American Community Cohort of the New York Metropolitan Area

纽约都会区亚裔美国人社区群体

基本信息

批准号：
10724342
负责人：
Jiyoung Ahn
金额：
$ 63.22万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-18 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10724342
关键词：
Address Adult Age American Area Asian Americans Atherosclerosis Behavioral Biological Biological Markers Blood Blood Vessels Cardiometabolic Disease Cardiovascular Diseases Chinese Chinese American Clinical Collaborations Collection Communities Community Outreach Community Participation Data Development Disease Disparity Endothelium Enrollment Environment Environmental Risk Factor Epidemiology Ethnic Population Event Extramural Activities Funding Genetic Genomics Goals Grant Health Home Institution Knowledge Korean American Koreans Life Style Limited English Proficiency Low income Measures Medical Research Metabolic Diseases Morbidity - disease rate Names Native Hawaiian or Other Pacific Islander New York Non-Insulin-Dependent Diabetes Mellitus Oral Outcome Participant Patient Recruitments Persons Population Questionnaires Recruitment Activity Research Research Infrastructure Retina Science Specialized Program of Research Excellence Surveys United States National Institutes of Health Urine Work biobank cancer health disparity cardiovascular health clinical examination clinically significant cohort community based participatory research data harmonization data sharing diet and exercise epidemiology study experience follow-up health disparity innovation marginalization metropolitan microbiome microbiome research mortality population health programs racial population recruit research study social culture social disparities sociocultural determinant stool sample urban area

项目摘要

ABSTRACT Asian Americans (AsA) are the fastest growing racial/ethnic group in the US, projected to double to 43 million people by 2050; however, our understanding of the factors that lead to disease or health in AsA is limited because AsA overall and specific AsA subpopulations have been severely under-represented in medical research. To address key population health research gaps, the NIH has called for a new epidemiologic cohort among AsA and Native Hawaiian/Pacific Islanders (NHPI). We propose to serve in this nation-wide initiative as a Clinical/Community Field Center for AsA in the New York Metropolitan Area. The overarching rationale for a national Asian American Community Cohort (here named the AACC) is to examine from a “populomics” perspective, the biological, lifestyle, behavioral/environmental and sociocultural factors that impact the health of AsA, with the ultimate goal of reducing morbidity and mortality. In the NY area, the AACC-NY will enroll Korean American adults—the most understudied AsA group—and Chinese American adults—the largest AsA group. A strong feature of AACC-NY is our capacity to target often-marginalized, low- income, non-English speaking communities in the NY area, who most often experience social and health disparities and who are often under-represented in epidemiologic research. The New York Metropolitan Area is home to the largest and most diverse AsA population of any urban region in the US, comprising 3.2 million residents, of which ~40% are Korean or Chinese American. In the longer term, CVD and other metabolic diseases such as type II diabetes will be our priority; however, the cohort also supports aims related to broad health outcomes, particularly through collaborations within the overall national cohort framework. In this funding period, leveraging our exceptionally strong community outreach, engagement, and community based participatory research programs with AsA communities, in Aim 1 we will enroll a cohort of 3200 AsA (age 25–64 years, including 1600 Korean and 1600 Chinese) and conduct participant follow up and surveillance activities, including ascertainment of events of clinical significance. In Aim 2 we will complete baseline exam, including questionnaire survey, physical exam, subclinical measure of CVD, and biospecimen collection. In Aim 3, we will complete data harmonization and sharing with Other Clinical/Community Field and Coordinating Centers. Aim 4 will focus on short-term research studies to examine the effect of sociocultural, diet/exercise, environment, and biological (genetics, microbiome) factors in relation to subclinical markers for cardiometabolic disease in overall and Korean and Chinese ethnic subgroups. The AACC is a unique urban platform with integrated community participation to address priority knowledge gaps regarding cardiovascular health and its disparities in specific AsA subpopulations. This research will provide the scientific basis for addressing these challenges in AsA communities, including the often marginalized and underserved.

抽象的亚裔美国人 (AsA) 是美国增长最快的种族/族裔群体，预计将翻一番，达到 4300 万到 2050 年，我们对导致 AsA 疾病或健康的因素的了解还有限，因为 AsA 总体和特定 AsA 亚群在医学研究中的代表性严重不足。为了解决关键的人口健康研究空白，NIH 呼吁在 AsA 中建立一个新的流行病学队列我们建议作为一名夏威夷原住民/太平洋岛民 (NHPI) 参与这项全国性倡议。纽约都会区 AsA 临床/社区现场中心。建立全国亚裔美国人社区队列（此处称为 AACC）的首要理由是从“大众组学”的角度审视生物学、生活方式、行为/环境和社会文化影响 AsA 健康的因素，最终目标是降低纽约地区的发病率和死亡率。 AACC-NY 将针对韩裔美国成年人（最受关注的 AsA 群体）和华裔美国人成年人——最大的 AsA 群体 AACC-NY 的一个强大特点是我们有能力瞄准经常被边缘化的、低收入群体。纽约地区最常经历社交和健康问题的非英语社区的收入纽约大都市区的人口差异和流行病学研究中的代表性往往不足。拥有美国所有城市地区中最大、最多样化的 AsA 人口，包括 320 万居民，其中约 40% 是韩裔或华裔美国人。从长远来看，CVD 和其他代谢性疾病。 II 型糖尿病等疾病将是我们的首要任务；然而，该队列还支持与广泛相关的目标健康成果，特别是通过在整个国家队列框架内的合作。在此资助期间，利用我们异常强大的社区外展、参与和社区基于与 AsA 社区的参与式研究项目，在目标 1 中，我们将招募 3200 名 AsA 群体（年龄 25-64岁，包括1600名韩国人和1600名中国人）并进行参与者跟踪和监测活动，包括确定具有临床意义的事件，在目标 2 中，我们将完成基线检查，包括问卷调查、体检、CVD 亚临床测量和生物样本采集。 3、我们将完成与其他临床/社区领域和协调的数据协调和共享目标 4 将侧重于短期研究，以检验社会文化、饮食/运动、与心脏代谢亚临床标志物相关的环境和生物（遗传学、微生物组）因素总体以及韩国和中国种族亚群的疾病。 AACC 是一个独特的城市平台，具有综合社区参与，旨在解决优先知识差距这项研究将提供有关心血管健康及其在特定 AsA 亚群中的差异的信息。解决 AsA 社区（包括经常被边缘化的群体）这些挑战的科学依据服务不足。