Expanding Translational Research in Arkansas

扩大阿肯色州的转化研究

• 批准号: 10672218
• 负责人: Laura P James
• 金额: $ 426.9万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10672218
• 关键词: Address; African American; Area; Arkansas; Cardiovascular Diseases; Clinical Research; Clinical and Translational Science Awards; Collaborations; Communities; Complex; Death Rate; Diabetes Mellitus; Ecosystem; Environment; Faculty; Fostering; Foundations; Future; Growth; Health; Health Benefit; Healthcare; Healthcare Systems; Home; Individual; Informatics; Institution; Interdisciplinary Study; Intervention; Knowledge; Lead; Link; Longevity; Measurable; Medical; Methods; Minority Groups; Mission; Obesity; Pediatric Hospitals; Population; Positioning Attribute; Poverty; Process; Research; Research Institute; Research Methodology; Research Personnel; Research Support; Research Training; Resistance; Resources; Rewards; Rural; Rural Population; Science; Site; Training; Training and Education; Translational Research; Underrepresented Populations; Universities; Veterans; Vision; Work; career; career development; community engagement; health care disparity; improved; innovation; metropolitan; novel strategies; programs; rural area; success; translational scientist

Contact PD/PI: James, Laura P PROJECT SUMMARY Overall The health challenges of Arkansas mandate that the University of Arkansas for Medical Sciences (UAMS) Translational Research Institute (TRI) works in partnership with communities and stakeholders to develop and conduct clinical and translational research (CTR) that will measurably improve the health of Arkansans. As the academic home for translational researchers, our Clinical and Translational Science Award (CTSA) hub has developed efficient and resourceful workflows, established excellent research training and educational programs, and launched initiatives to support the growth of team science and community engagement. With maturation of our hub, we have expanded our integration with our participating sites, Arkansas Children’s Hospital (ACH) and the Central Arkansas Veteran’s Healthcare System (CAVHS), which provides us with diverse perspectives and a collaborative foundation of multidisciplinary research across these three closely- linked institutions. Collectively, hub faculty from UAMS, ACH, and CAVHS have rich expertise in CTR engaging rural and underrepresented populations and will help us expand CTR resources more broadly. Our vision is to be a thriving translational research ecosystem that catalyzes discoveries into health solutions for rural and underrepresented populations. Our future work, based on our previous accomplishments, will be guided by the following five specific aims: Aim 1). Enrich our environment for CTR by supporting and rewarding team-based collaborations at the local and national level; Aim 2). Enhance training to researchers across the translational research spectrum and at all career levels through innovative and team-based approaches; Aim 3). Increase partnerships with diverse stakeholders to expand the impact of clinical and translational research in and with rural populations; Aim 4). Streamline translational research processes and enhance research quality with state-of-the-art informatics approaches and methods; and Aim 5). Expand clinical and translational research opportunities across the lifespan and in underrepresented populations. The collective impact of our success as a CTSA hub will provide “real world solutions” for effective CTR in rural and underrepresented populations, a facet insufficiently represented within the CTSA Consortium. Page 303 Project Summary/Abstract Contact PD/PI: James, Laura P

联系PD/PI：James，Laura P 项目摘要 全面的 阿肯色州的健康挑战要求阿肯色大学医学科学（UAMS） 转化研究所（TRI）与社区和利益相关者合作发展和 进行临床和翻译研究（CTR），可以衡量地改善阿肯色州的健康状况。作为 翻译研究人员的学术主场，我们的临床和转化科学奖（CTSA）中心已有 开发了高效且足智多谋的工作流程，建立了出色的研究培训和教育 计划，并发起了支持团队科学和社区参与的成长的举措。和 枢纽的成熟，我们扩大了与参与网站的集成，阿肯色州儿童 医院（ACH）和阿肯色州中央资深医疗保健系统（CAVHS），它为我们提供了 潜水员的观点和这三个近距离研究的多学科研究的合作基础 链接的机构。总体而言，UAMS，ACH和CAVH的枢纽教师在CTR方面拥有丰富的专业知识 参与粗糙和代表性不足的人群，将有助于我们更广泛地扩展CTR资源。我们的 愿景将成为一个蓬勃发展的转化研究生态系统，将发现催化为健康解决方案 粗糙且代表性不足的人群。我们的未来工作，基于我们以前的成就，将是 在以下五个特定目标的指导下：目标1）。通过支持和奖励的CTR环境 基于团队的地方和国家一级的合作；目标2）。增强对整个研究人员的培训 通过创新和基于团队的方法，转化研究范围以及所有职业水平；目的 3）。增加与潜水员利益相关者的伙伴关系，以扩大临床和翻译研究的影响 在大量的人口中；目标4）。简化翻译研究过程并增强研究 具有最先进的信息方法和方法的质量；和目标5）。扩展临床和翻译 整个生命周期和代表性不足的人群的研究机会。我们的集体影响 作为CTSA枢纽的成功将提供“现实世界的解决方案”，以使其在粗糙和代表性不足的情况下有效CTR 种群是CTSA财团内代表不足的方面。 第303页 项目摘要/摘要 联系PD/PI：James，Laura P

项目成果

Insertion sequences and other mobile elements associated with antibiotic resistance genes in Enterococcus isolates from an inpatient with prolonged bacteraemia.

• DOI: 10.1099/mgen.0.000855
• 发表时间: 2022-08
• 期刊: MICROBIAL GENOMICS
• 影响因子: 3.9
• 作者: Udaondo, Zulema;Abram, Kaleb Z.;Kothari, Atul;Jun, Se - Ran
• 通讯作者: Jun, Se - Ran

Development of a potential opioid misuse measure from administrative dispensing data and contrasting opioid misuse among individuals on long-term tramadol, long-term short-acting hydrocodone or long-term short-acting oxycodone therapy in Arkansas.

• DOI: 10.1080/03007995.2022.2112874
• 发表时间: 2022-11
• 期刊: Current medical research and opinion
• 影响因子: 2.3

Sociodemographic Determinants of COVID-19 Vaccine Hesitancy, Fear of Infection, and Protection Self-Efficacy.

• DOI: 10.1177/21501327211040746
• 发表时间: 2021-01
• 期刊: Journal of primary care & community health
• 影响因子: 3.6
• 作者: McElfish PA;Willis DE;Shah SK;Bryant-Moore K;Rojo MO;Selig JP
• 通讯作者: Selig JP

Allergen-specific T cells and clinical features of food allergy: Lessons from CoFAR immunotherapy cohorts.

• DOI: 10.1016/j.jaci.2021.09.029
• 发表时间: 2022-04
• 期刊: The Journal of allergy and clinical immunology
• 作者: Berin MC;Agashe C;Burks AW;Chiang D;Davidson WF;Dawson P;Grishin A;Henning AK;Jones SM;Kim EH;Leung DYM;Masilamani M;Scurlock AM;Sicherer SH;Wood RA;Sampson HA
• 通讯作者: Sampson HA

"Life is hard": How the COVID-19 pandemic affected daily stressors of women.

• DOI: 10.1016/j.dialog.2022.100018
• 发表时间: 2022-12
• 期刊: Dialogues in health
• 作者: Purvis, Rachel S;Ayers, Britni L;Rowland, Brett;Moore, Ramey;Hallgren, Emily;McElfish, Pearl A
• 通讯作者: McElfish, Pearl A