Improving Waisman Center Animal Care Facility

改善魏斯曼中心动物护理设施

• 批准号: 7249201
• 负责人: ALBEE MESSING
• 金额: $ 70万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-15 至 2008-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7249201
• 关键词: Address; Animal Disease Models; Animal Experimentation; Animals; Appendix; Area; Behavior; Behavioral; Biohazardous Substance; Biological; Biological Sciences; Biomedical Research; Brain imaging; Budgets; Clinical; Clinical Research; Comprehensive Health Care; Condition; Crowding; Developmental Disabilities; Direct Costs; Elements; Embryo; Environment; Equipment; Facility Construction Funding Category; Faculty; Floor; Funding; Genetic; Gifts; Goals; Housing; Human; Interdisciplinary Study; Investigation; Laboratory Research; Mechanics; Medical Surveillance; Mission; Molecular and Cellular Biology; Mus; National Center for Research Resources; Nature; Neurodegenerative Disorders; Operative Surgical Procedures; Quarantine; Rattus; Research; Research Infrastructure; Research Personnel; Research Training; Rodent; Schedule; Schools; Science; Security; Services; Site; Source; Sterility; System; Text; Time; TimeLine; Universities; Vendor; Water; Wisconsin; animal care; animal facility; biological research; cost; density; drinking water; foot; gene therapy; improved; medical specialties; nerve stem cell; nervous system disorder; programs; repaired; research study; response; segregation

DESCRIPTION (provided by applicant): The Waisman Center at the University of Wisconsin-Madison is one of thirteen NIH-funded centers focused on developmental disabilities and neurodegenerative diseases, with a broad mission that encompasses research, training, and clinical activities. Since its inception in 1973 the Center has included an animal facility as a key element of its infrastructure and one of its scientific core services, yet little has been done to upgrade the facility to allow it to keep pace with the needs of current science. During the past six years both internal and external reviews identified critical shortcomings in our animal facility that needed to be addressed. Eighteen months ago both the main and backup cage-washers failed and could not be repaired, forcing evacuation of the entire facility. We have formulated a comprehensive plan for renovation, the overall cost of which is approximately $2.7 million (the majority paid for by university and gift funds). The goal of this renovation is to support Waisman Center investigators and affiliates by 1) increasing capacity in what is now a rodent-only facility, 2) improving barrier functions through increased use of microisolation, purchase and installation of biohazard hoods for selected areas, purchase and installation of an on-site autoclave for support of immunodeficient animals, and creation of dedicated quarantine space, 3) upgrading infrastructure by replacing outdated equipment for cage washing, installing, a disposable pouch system for supplying drinking water, installing ceilings to improve environmental control, and repairing flooring throughout, 4) improving security by installation of video surveillance systems and card-access controls, and 5) creating a suite of rooms optimized for long-term behavioral studies that is separate from the barrier portion of the facility.

描述（由申请人提供）：威斯康星大学麦迪逊分校的魏斯曼中心是 NIH 资助的 13 个中心之一，专注于发育障碍和神经退行性疾病，其使命广泛，涵盖研究、培训和临床活动。自 1973 年成立以来，该中心已将动物设施作为其基础设施的关键要素和科学核心服务之一，但几乎没有采取任何措施来升级该设施以使其跟上当前科学的需求。在过去的六年中，内部和外部审查都发现了我们动物设施中需要解决的严重缺陷。十八个月前，主笼式清洗机和备用笼式清洗机都发生故障且无法修复，迫使整个设施疏散。我们制定了全面的翻修计划，总成本约为270万美元（大部分由大学和捐赠基金支付）。此次改造的目标是通过以下方式支持威斯曼中心的研究人员和附属机构：1) 提高目前仅限啮齿类动物的设施的容量，2) 通过增加微隔离的使用、为选定区域购买和安装生物危害罩来改善屏障功能、购买安装现场高压灭菌器以支持免疫缺陷动物，并创建专用检疫空间，3）通过更换过时的笼子清洗设备来升级基础设施，安装用于供应饮用水的一次性袋系统，安装天花板以改善环境控制，并修复整个地板，4）通过安装视频监控系统和卡访问控制来提高安全性，5）创建一套针对长期行为研究而优化的房间，该房间与屏障部分分开该设施的。