The Pittsburgh Scientific and Data Research Center for the COPE-AKI Consortium (Pitt-SDRC)

COPE-AKI 联盟匹兹堡科学与数据研究中心 (Pitt-SDRC)

基本信息

批准号：
10670114
负责人：
Kaleab Z Abebe
金额：
$ 80.72万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-19 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10670114
关键词：
Acute Acute Renal Failure with Renal Papillary Necrosis Address Adverse event Ambulatory Care Biometry Cardiovascular system Caring Cessation of life Chronic Kidney Failure Clinical Clinical Data Clinical Trials Clinical Trials Design Collaborations Conduct Clinical Trials Consensus Continuity of Patient Care Data Data Analyses Data Collection Data Coordinating Center Development Dialysis procedure Education End stage renal failure Gills Glucose Goals Health Hospitalization Hospitals Impaired health Incidence Information Dissemination Injury to Kidney Intervention Kidney Kidney Diseases Knowledge Manuals Measurement Medical Medication Management Monitor Morbidity - disease rate Nurses Online Systems Outcomes and Health Services Research Participant Patient Discharge Patient Outcomes Assessments Patient-Focused Outcomes Patients Persons Pharmacists Phase Population Procedures Process Protocols documentation Randomized Recording of previous events Records Recurrence Renin-Angiotensin-Aldosterone System Reporting Research Research Design Risk Risk Factors Safety Sodium Symptoms Syndrome System Technology Testing United States National Institutes of Health Universities adverse outcome cardiovascular risk factor care coordination clinical center clinically relevant data dissemination data management data quality design disability evidence base experience follow-up health management health related quality of life high risk hospital care hospital readmission improved kidney dysfunction multi-component intervention multidisciplinary operation patient engagement patient oriented pharmacologic primary outcome process optimization programs protocol development readmission rates satisfaction success symporter telehealth treatment as usual virtual visit

项目摘要

ABSTRACT Acute kidney injury (AKI) and chronic kidney disease (CKD) are “interconnected” syndromes in which each influences the other. CKD is a risk factor for AKI and AKI contributes to the development or progression of CKD, end-stage renal disease (ESRD), cardiovascular symptoms, and death, not to mention recurrent AKI episodes and impaired health-related quality of life (HRQoL). Processes of care after AKI hospitalization have been found to be suboptimal, with lack of continuity of care, delayed follow-up and suboptimal medication management exacerbating the risks of adverse outcomes. In addition, optimal pharmacologic therapy, such as blockade of the renin-angiotensin-aldosterone system (RAAS) or sodium-glucose cotransporter type 2 (SGLT2), has not been defined. The Caring for OutPatiEnts after Acute Kidney Injury (COPE-AKI) Consortium will address these important gaps in knowledge of optimal management of patients surviving an episode of moderate (stage 2) or severe (stage 3) AKI. The goal of the COPE-AKI Consortium will be to develop and test interventions to optimize processes of care and identify key pharmacologic and non-pharmacologic interventions to reduce morbidity among these high-risk patients. The Center for Clinical Trials & Data Coordination (CCDC) at the University of Pittsburgh is well poised to serve as the Scientific and Data Research Center (SDRC) for the COPE-AKI Consortium. Our multidisciplinary investigative team has a history of collaboration, wealth of experience and expertise, including expertise in acute and chronic kidney disease, critical and translational care, medication management, design of clinical trials, telehealth, clinical and data coordination, project administration support, biostatistics, measurement of patient-reported outcomes, health services research and patient engagement. Our goal is to serve as the Scientific and Data Research Center for the COPE-AKI Consortium. Specifically, we will 1) establish an efficient and rigorous process for designing the Consortium study, including protocol development and adaptation of an existing web-based data collection system; 2) provide comprehensive expertise for data management and analysis within the Consortium; and 3) provide program coordination and administrative support throughout all phases of the study.

抽象的急性肾损伤 (AKI) 和慢性肾病 (CKD) 是“相互关联”的综合征两者相互影响，CKD 是 AKI 的危险因素，而 AKI 又会导致 AKI 的发生。 CKD 的发生或进展、终末期肾病 (ESRD)、心血管症状、和死亡，更不用说反复发生 AKI 发作和健康相关生活质量受损 (HRQoL)。AKI 住院后的护理过程并不理想，缺乏连续性护理、延迟随访和次优药物管理此外，最佳的药物治疗，如加剧不良后果的风险。阻断肾素-血管紧张素-醛固酮系统 (RAAS) 或钠-葡萄糖协同转运蛋白 2 型 (SGLT2)，尚未定义。急性肾损伤后门诊病人的护理。 (COPE-AKI) 联盟将解决最优知识方面的这些重要差距对中度（2 期）或重度（3 期）AKI 发作后幸存的患者进行管理。 COPE-AKI 联盟的目标是开发和测试干预措施以优化护理过程并确定关键的药物和非药物干预措施降低这些高危患者的发病率。匹兹堡大学协调中心 (CCDC) 已准备好充当科学和 COPE-AKI 联盟的数据研究中心 (SDRC) 我们的多学科。调查团队有着合作历史、丰富的经验和专业知识，包括急慢性肾病、重症和转化护理、药物治疗方面的专业知识管理、临床试验设计、远程医疗、临床和数据协调、项目管理支持、生物统计学、患者报告结果的测量、健康我们的目标是成为科学和数据服务的研究和患者参与。具体来说，我们将 1) 建立一个高效且高效的 COPE-AKI 联盟研究中心。设计联盟研究的严格流程，包括方案开发和改编现有的基于网络的数据收集系统；2) 提供全面的专业知识；用于联盟内部的数据管理和分析；以及 3) 提供项目协调；以及整个研究各个阶段的行政支持。