Biomedical Informatics Shared Resource

生物医学信息学共享资源

基本信息

批准号：
10661635
负责人：
Aris Floratos
金额：
$ 8.08万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-07-04 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10661635
关键词：
Adopted Adoption Applications Grants Basic Cancer Research Bioinformatics Biological Markers Biomedical Research Cancer Biology Cancer Center Support Grant Cancer Etiology Cells Collection Communities Complex Computational Biology Consult Data Data Analyses Data Set Data Storage and Retrieval Databases Dedications Development Disease Progression Doctor of Philosophy Ensure Environment Experimental Designs Faculty Flow Cytometry Funding Genomics Goals Herbert Irving Comprehensive Cancer Center High Performance Computing Human Resources Individual Informatics Infrastructure Investigation Journals Knowledge Laboratories Literature Maintenance Malignant Neoplasms Manuscripts Mediating Memory Methodology Methods Molecular NCI Center for Cancer Research Nature Paper Phenotype Play Process Proteomics Publications Research Research Peer Review Research Personnel Research Project Grants Resources Sample Size Services Signal Transduction System Systems Biology Technology Therapeutic Training Training and Education Translational Research United States National Institutes of Health Universities Update Validation Work analytical method analytical tool anticancer research biological research biomedical informatics cancer cell cancer education cancer therapy computational pipelines computer cluster computer infrastructure computerized tools computing resources cost cost effective data repository drug mechanism experience gene regulatory network genomic data high throughput technology informatics shared resource informatics tool insight lipidomics member metabolomics multidimensional data novel operation petabyte programs repository statistics stem cells success technology platform terabyte tool transcriptomics translational cancer research treatment response

项目摘要

BIOMEDICAL INFORMATICS SHARED RESOURCE: PROJECT SUMMARY The Biomedical Informatics Shared Resource (BISR), directed by Aris Floratos, PhD, provides members of the Herbert Irving Comprehensive Cancer Center (HICCC) with access to the knowledge and expertise of specialized personnel and a computational infrastructure that supports integrative analyses of genomic, transcriptomic, and large-scale proteomic data. Such analyses are complex but essential for basic and translational cancer research, which increasingly requires the use of multi-dimensional data generated by high throughput technologies. Through the BISR, HICCC members gain cost-effective access to experienced staff with strong cross-disciplinary knowledge in cancer biology, informatics, and statistics. Working closely with HICCC members, they to help answer research questions using state-of-the-art computational and statistical approaches. Services offered include: (1) guiding experimental design to ensure adequately powered downstream analyses; (2) providing the full analysis component of laboratory and translational investigations; (3) assisting in the development of the bioinformatic portions of papers and grant applications; (4) assisting in the submission of genomic data to NIH data repositories; and (5) providing education and training in the use of informatics methods. In addition to using well-established computational pipelines based on community- accepted best practices, the BISR applies novel systems biology methodologies to characterize regulatory processes that mediate cancer establishment, maintenance, and progression as well as response to treatment. These powerful methodologies have been developed by faculty within the Department of Systems Biology and have been used with remarkable success to elucidate regulatory and signaling programs that play key roles in coordinating cell-state transitions across many cancer phenotypes. To support its operations, the BISR maintains a large collection of biomedical informatics tools and databases in addition to utilizing the world-class computational infrastructure of Columbia University’s Center for Computational Biology and Bioinformatics, which includes one of the largest academic computer clusters dedicated to biological research. During the current project period (2014-2019), the BISR was utilized by 46 HICCC members across all HICCC Research Programs and provided key data and insights to support 17 peer-reviewed research grants and 34 HICCC member publications including work in 13 journals with an impact factor >10, of which 10 were in journals with an impact factor >20 (Nature, Cancer Cell, and Cell Stem Cell). As technologies evolve and new methods of analysis emerge, the BISR is committed to continuously updating service offerings to meet the research needs of HICCC members through adoption of new methodologies for data analysis, new analytical approaches, and enhancement of existing analytical methods.

生物医学信息学共享资源：项目摘要由 Aris Floratos 博士指导的生物医学信息学共享资源 (BISR) 为成员提供赫伯特·欧文综合癌症中心 (HICCC) 可以利用以下机构的知识和专业知识专业人员和支持基因组综合分析的计算基础设施，转录组和大规模蛋白质组数据的分析很复杂，但对于基础和分析至关重要。转化癌症研究，越来越需要使用高通量生成的多维数据通过 BISR，HICCC 成员可以经济高效地接触经验丰富的员工。在癌症生物学、信息学和统计学方面拥有丰富的跨学科知识，并与他们密切合作。 HICCC 成员，他们使用最先进的计算和统计方法帮助回答研究问题提供的服务包括：（1）指导实验设计以确保充足的动力。下游分析；(2) 提供实验室和转化研究的完整分析部分； (3) 协助开发论文和资助申请的生物信息学部分；向 NIH 数据存储库提交基因组数据；(5) 提供使用方面的教育和培训；除了使用基于社区的完善的计算管道之外。 BISR 采用新颖的系统生物学方法来表征监管的最佳实践介导癌症形成、维持和进展以及对治疗的反应的过程。这些强大的方法是由系统生物学系和已被用来阐明在协调多种癌症表型的细胞状态转变为了支持其运作，BISR 坚持认为。除了利用世界一流的生物医学信息学工具和数据库之外，还收集了大量的生物医学信息学工具和数据库哥伦比亚大学计算生物学和生物信息学中心的计算基础设施，其中包括致力于生物研究的最大学术计算机集群之一。当前项目期间（2014-2019），BISR 被所有 HICCCC 研究的 46 名 HICCCC 成员使用制定计划并提供关键数据和见解，以支持 17 项同行评审研究资助和 34 项 HICCC 成员出版物包括在 13 种影响因子 >10 的期刊上发表的作品，其中 10 种发表在影响因子大于 10 的期刊上随着技术的发展和新方法的发展，影响因子>20（自然、癌细胞和细胞干细胞）。分析表明，BISR 致力于不断更新服务产品以满足研究需求通过采用新的数据分析方法、新的分析方法和加强现有的分析方法。