Digital Mindfulness Meditation-enhanced Cognitive Behavioral Therapy (CBT-MM) for Binge Eating Disorder

数字正念冥想增强认知行为疗法（CBT-MM）治疗暴食症

基本信息

批准号：
10661161
负责人：
Margarita Sala
金额：
$ 15.41万
依托单位：
YESHIVA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-01 至 2028-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10661161
关键词：
Address Affect Aftercare American Area Award Behavioral Benchmarking Binge Eating Binge eating disorder Clinical Cognitive Therapy Combined Modality Therapy Conduct Clinical Trials Development Disease Disease remission Eating Eating Disorders Elements Eligibility Determination Emotions Feedback Frequencies Guidelines Health Services Accessibility Individual Intervention Interview Length Logistics Maintenance Measures Meditation Mental Depression Mentorship Mindfulness Training Monitor National Center for Complementary and Integrative Health Obesity Outcome Overweight Participant Pathway interactions Phase Population Protocols documentation Public Health Qualitative Methods Quality of life Randomized Randomized, Controlled Trials Research Research Project Grants Role Shapes Source Specialist Symptoms System Technology Testing Training Transportation Wait Time Weight acceptability and feasibility career cognitive enhancement comparative efficacy cost depressive symptoms dietary digital digital delivery digital treatment effective therapy efficacy evaluation emotion dysregulation follow up assessment follow-up improved indexing innovation mindfulness mindfulness meditation novel primary outcome prototype psychosocial recruit relapse patients skills smartphone application theories therapy development trait usability user centered design virtual web app

项目摘要

PROJECT SUMMARY/ABSTRACT Binge eating disorder (BED) is a prevalent disorder, affecting 3.5% of Americans. BED is maintained by two- pathways: (1) dietary over-restriction and (2) emotion dysregulation. Current treatments for BED, such as Cognitive Behavioral Therapy (CBT) produce suboptimal results because they only target over-restriction. Mindfulness meditation (MM) targets emotion dysregulation and could thus be an important addition to CBT for Eating Disorders. Furthermore, digital delivery of an MMT for BED would offer unprecedented scalability, but there are no current digital MMTs for BED. The current K23 proposal involves developing a digital Mindfulness Meditation-enhanced Cognitive Behavioral Therapy (CBT-MM) for BED via two phases. CBT-MM will target the two different mechanisms of BED (dietary over-restriction and emotion dysregulation). In Phase 1, I will finalize the development of digital CBT-MM via interview-based user testing. In Phase 2, I will conduct a pilot feasibility randomized controlled trial (RCT). For the RCT, 40 individuals with BED recruited nationally will be randomized to digital: 1) CBT-MM (n = 20); or 2) an already developed digital CBT treatment (iTakeControl) only (n = 20). The RCT will be conducted virtually, with video-based assessments at baseline, mid- and post-treatment, and 3-month follow up. Aim 1 is to develop digital CBT-MM. Aim 2 is to evaluate feasibility and acceptability. Aim 3 is to measure within-group changes from pre-to post treatment on binge eating remission, binge eating frequency, weight, quality of life, depressive symptoms, emotion dysregulation, dietary over-restriction, and trait mindfulness. This project has the potential for developing an innovative, theory-driven, efficacious, and scalable mindfulness-based treatment for BED that can have a large public health impact. To carry out this K23, I will receive mentorship from a leading team of experts in the areas of mindfulness, CBT for eating disorders, technology-based treatment development, and qualitative methods. This K23 will specifically facilitate my training in: (1) developing and refining mindfulness-based eating and weight disorder treatments; (2) technology-based treatment development, (3) formalized training in conducting clinical trials, and (4) qualitative methods for intervention development. This award will serve as a launching point for my career as I leverage the training and research skills afforded by this award to become a leader in the field of digital mindfulness-based treatment development for eating and weight disorders.

项目摘要/摘要暴饮暴食（BED）是一种普遍的疾病，影响了3.5％的美国人。床由两个途径：（1）饮食过度限制和（2）情绪失调。当前的床治疗认知行为疗法（CBT）产生次优结果，因为它们仅针对过度限制。正念冥想（MM）靶向情绪失调，因此可能是CBT的重要补充饮食失调。此外，床MMT的数字交付将提供前所未有的可伸缩性，但目前没有床的数字MMT。当前的K23提案涉及开发数字正念通过两个阶段为床的冥想增强的认知行为疗法（CBT-MM）。 CBT-MM将针对床的两种不同的机制（饮食过度限制和情绪失调）。在第1阶段，我将最终确定通过基于面试的用户测试开发数字CBT-MM。在第2阶段，我将进行飞行员的可行性随机对照试验（RCT）。对于RCT，全国招募床的40个人将被随机分配到数字：1）CBT-MM（n = 20）;或2）仅开发的数字CBT处理（ITAKECONTOL）（n = 20）。 RCT实际上将进行基线，中和后处理，并进行基于视频的评估，以及 3个月的随访。目标1是开发数字CBT-MM。目标2是评估可行性和可接受性。目标3 是衡量组内的变化，从治疗前的治疗前进行暴饮暴食，暴饮暴食频率，体重，生活质量，抑郁症状，情绪失调，饮食过度限制和特质正念。该项目具有开发创新，理论驱动，有效的潜力可扩展的基于正念的床治疗可能会对公共卫生产生巨大影响。执行此操作 K23，我将获得正念领域的领先专家团队，CBT饮食疾病，基于技术的治疗发展和定性方法。这个K23将专门促进我在以下方面的培训：（1）开发和完善基于正念的饮食和体重障碍治疗；（2）基于技术的治疗开发，（3）进行临床试验的正式培训和（4）干预开发的定性方法。该奖项将成为我职业生涯的一个发射点利用该奖项提供的培训和研究技能成为数字领域的领导者基于正念的饮食和体重疾病的治疗发展。