Digital Mindfulness Meditation-enhanced Cognitive Behavioral Therapy (CBT-MM) for Binge Eating Disorder

数字正念冥想增强认知行为疗法（CBT-MM）治疗暴食症

基本信息

批准号：
10661161
负责人：
Margarita Sala
金额：
$ 15.41万
依托单位：
YESHIVA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-01 至 2028-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10661161
关键词：
Address Affect Aftercare American Area Award Behavioral Benchmarking Binge Eating Binge eating disorder Clinical Cognitive Therapy Combined Modality Therapy Conduct Clinical Trials Development Disease Disease remission Eating Eating Disorders Elements Eligibility Determination Emotions Feedback Frequencies Guidelines Health Services Accessibility Individual Intervention Interview Length Logistics Maintenance Measures Meditation Mental Depression Mentorship Mindfulness Training Monitor National Center for Complementary and Integrative Health Obesity Outcome Overweight Participant Pathway interactions Phase Population Protocols documentation Public Health Qualitative Methods Quality of life Randomized Randomized, Controlled Trials Research Research Project Grants Role Shapes Source Specialist Symptoms System Technology Testing Training Transportation Wait Time Weight acceptability and feasibility career cognitive enhancement comparative efficacy cost depressive symptoms dietary digital digital delivery digital treatment effective therapy efficacy evaluation emotion dysregulation follow up assessment follow-up improved indexing innovation mindfulness mindfulness meditation novel primary outcome prototype psychosocial recruit relapse patients skills smartphone application theories therapy development trait usability user centered design virtual web app

项目摘要

PROJECT SUMMARY/ABSTRACT Binge eating disorder (BED) is a prevalent disorder, affecting 3.5% of Americans. BED is maintained by two- pathways: (1) dietary over-restriction and (2) emotion dysregulation. Current treatments for BED, such as Cognitive Behavioral Therapy (CBT) produce suboptimal results because they only target over-restriction. Mindfulness meditation (MM) targets emotion dysregulation and could thus be an important addition to CBT for Eating Disorders. Furthermore, digital delivery of an MMT for BED would offer unprecedented scalability, but there are no current digital MMTs for BED. The current K23 proposal involves developing a digital Mindfulness Meditation-enhanced Cognitive Behavioral Therapy (CBT-MM) for BED via two phases. CBT-MM will target the two different mechanisms of BED (dietary over-restriction and emotion dysregulation). In Phase 1, I will finalize the development of digital CBT-MM via interview-based user testing. In Phase 2, I will conduct a pilot feasibility randomized controlled trial (RCT). For the RCT, 40 individuals with BED recruited nationally will be randomized to digital: 1) CBT-MM (n = 20); or 2) an already developed digital CBT treatment (iTakeControl) only (n = 20). The RCT will be conducted virtually, with video-based assessments at baseline, mid- and post-treatment, and 3-month follow up. Aim 1 is to develop digital CBT-MM. Aim 2 is to evaluate feasibility and acceptability. Aim 3 is to measure within-group changes from pre-to post treatment on binge eating remission, binge eating frequency, weight, quality of life, depressive symptoms, emotion dysregulation, dietary over-restriction, and trait mindfulness. This project has the potential for developing an innovative, theory-driven, efficacious, and scalable mindfulness-based treatment for BED that can have a large public health impact. To carry out this K23, I will receive mentorship from a leading team of experts in the areas of mindfulness, CBT for eating disorders, technology-based treatment development, and qualitative methods. This K23 will specifically facilitate my training in: (1) developing and refining mindfulness-based eating and weight disorder treatments; (2) technology-based treatment development, (3) formalized training in conducting clinical trials, and (4) qualitative methods for intervention development. This award will serve as a launching point for my career as I leverage the training and research skills afforded by this award to become a leader in the field of digital mindfulness-based treatment development for eating and weight disorders.

项目概要/摘要暴食症 (BED) 是一种普遍存在的疾病，影响 3.5% 的美国人。 BED 由两个维护者维护途径：（1）饮食过度限制和（2）情绪失调。目前针对 BED 的治疗方法，例如认知行为疗法 (CBT) 的效果并不理想，因为它们只针对过度限制。正念冥想（MM）针对的是情绪失调，因此可以成为 CBT 的重要补充。饮食失调。此外，BED 的 MMT 数字化交付将提供前所未有的可扩展性，但是目前没有针对 BED 的数字 MMT。当前的 K23 提案涉及开发数字正念针对 BED 的冥想增强认知行为疗法 (CBT-MM) 分为两个阶段。 CBT-MM 将针对 BED 的两种不同机制（饮食过度限制和情绪失调）。在第一阶段，我将完成通过基于访谈的用户测试开发数字 CBT-MM。在第二阶段，我将进行试点可行性随机对照试验（RCT）。对于 RCT，将在全国范围内招募 40 名 BED 患者进行随机分组数字化：1) CBT-MM (n = 20)；或 2) 仅已开发的数字 CBT 治疗 (iTakeControl) (n = 20)。随机对照试验将虚拟进行，在基线、治疗中期和治疗后进行基于视频的评估， 3个月随访。目标 1 是开发数字 CBT-MM。目标 2 是评估可行性和可接受性。目标 3 是为了测量治疗前和治疗后暴食缓解、暴食的组内变化频率、体重、生活质量、抑郁症状、情绪失调、饮食过度限制以及特质正念。该项目有潜力开发一种创新的、理论驱动的、有效的、基于正念的可扩展治疗暴食症，可以对公共健康产生巨大影响。为了执行这个 K23，我将接受正念、饮食 CBT 领域领先专家团队的指导疾病、基于技术的治疗开发和定性方法。这款K23将专门促进我在以下方面的培训：（1）开发和完善基于正念的饮食和体重障碍治疗方法； (2) 基于技术的治疗开发，(3) 进行临床试验的正规培训，以及 (4) 干预开发的定性方法。这个奖项将成为我职业生涯的起点，因为我利用该奖项提供的培训和研究技能，成为数字领域的领导者基于正念的饮食和体重障碍治疗方法的开发。