Research and Methods Core

研究和方法核心

• 批准号: 10661409
• 负责人: David H Rehkopf
• 金额: $ 38.12万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-26 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10661409
• 关键词: Address; Area; Behavioral; Cancer Burden; Cancer Etiology; Categories; Centers for Population Health; Collaborations; Collection; Colorectal Cancer; Communities; County; Data; Data Collection; Dedications; Development; Disease; Doctor of Philosophy; Ensure; Environmental Risk Factor; Funding; Health Sciences; Incidence; Income; Individual; Inequity; Intervention; Latino; Leadership; Long-Term Effects; Malignant Neoplasms; Measures; Methodology; Methods; Mission; Modeling; Natural experiment; Pilot Projects; Play; Population; Poverty Areas; Prevention; Prevention Research; Process; Productivity; Reproducibility; Research; Research Methodology; Research Personnel; Research Project Grants; Role; Surveys; Training; Universities; Vietnamese; Work; cancer prevention; career; dashboard; data curation; data resource; experimental study; insight; interoperability; intervention program; mathematical model; poor communities; prevent; social factors; social health determinants; synergism

Research and Methods Core: Project Summary The focus of our proposed UPSTREAM Research Center is examining the impacts of income intervention programs for reducing the long-term burden of cancer in persistent poverty areas. Our proposal to achieve this is through a scientific and collaborative process that prioritizes both the overlapping and also distinct needs of the Latino and Vietnamese communities in the persistent poverty areas of Santa Clara County and Yolo County, CA. The rationale for this approach is that there is robust evidence supporting a fundamental causes approach to cancer prevention – that is, only through intervening on the “causes of the causes” will we make substantial progress in reducing the cancer burden in persistent poverty areas. We cannot rely solely on individual or group behavioral change interventions alone for population reductions in the cancer burden; we must move ‘upstream’. The Research & Methods Core will support this mission through: Aim 1. Coordinating data collection, measures and methods and ensuring the interoperability of both quantitative and qualitative data within the Center and between Centers, Aim 2. Modeling the long-term effects of the project interventions and other exposures on colorectal cancer incidence, Aim 3. Coordinating with the projects and Cores to create data dashboards and insights with the persistent poverty communities in ways that will most benefit community led actions in cancer prevention, Aim 4. Evaluating the Center’s research productivity and impact over the funding period. The Research and Methods Core will address the needs of the Research projects by coordinating the collection of similar measures across research projects to enable inference as to the relative value of different income intervention programs, working with project investigators to coordinate methodological approaches for inference, and coordinating with project investigators to use estimates from their analytic data based models for inputs to a mathematical model that will predict population level changes in colorectal cancer incidence in persistent poverty areas. Across all of the above processes, the Research & Methods Core will evaluate the Center’s research productivity and impact over the funding period as part of the leadership team aims outlined in the Administrative Core. The mission of the Research and Methods Core is driven by two intertwining areas of intended impact – 1) robust and reproducible scientific discovery on the impact of income interventions on preventing cancer in persistent poverty areas in combination with 2) building capacity for cancer prevention research in those areas. Our team sees these as inseparable objectives. Despite the compelling evidence for the impact of addressing social determinants of health as fundamental causes of disease, less of this work has been based on actual interventions and actions, and even less of this work in relation to cancer incidence. To build capacity for prevention in persistent poverty areas, this scientific research needs to be co-produced with these communities in order to have the greatest impact, and the Research & Methods Core will play a part in this mission of our Center.

研究与方法核心：项目摘要 我们拟议的上游研究中心的重点是检查收入干预的影响 减少持续性贫困地区癌症长期癌症的计划。我们实现这一目标的建议 通过一个科学和协作的过程，优先考虑重叠和不同的需求 圣克拉拉县持续贫困地区的拉丁裔和越南社区和尤洛 加利福尼亚州县这种方法的理由是有强大的证据支持基本原因 预防癌症的方法 - 也就是说，只有通过介入“原因的原因”，我们才能做出 在减少持续性贫困地区癌症燃烧方面的巨大进展。我们不能仅仅依靠 单独的个人或团体行为改变干预措施，用于减少癌症的人口降低； 必须移动“上游”。研究与方法核心将通过以下方面支持此任务：AIM 1。协调 数据收集，测量和方法，并确保定量和定性的互操作性 中心内和中心之间的数据，目标2。建模项目干预的长期影响 以及其他关于结直肠癌事件的暴露，目标3。与项目和核心协调以创建 数据仪表板和与持续的贫困社区的见解，以最大程度地使社区受益的方式 领导预防癌症的行动，目标4。评估该中心的研究生产力和对 资金期。研究和方法核心将通过 协调跨研究项目的类似措施的收集，以推断相对 不同收入干预计划的价值，与项目调查人员合作以协调 推理方法学方法，并与项目调查人员协调以使用估计值 他们针对数学模型的输入的基于分析数据的模型，该模型将预测人群级别的变化 持续贫困地区的结直肠癌发病率。在上述所有过程中，研究和 方法核心将评估该中心的研究生产力和在资金期间的影响 领导团队的目标是行政核心。研究和方法的使命核心是 受两个预期影响的互动领域的驱动 - 1）关于 感染干预措施对预防持续贫困地区癌症的影响与2）建筑 这些领域的癌症预防研究能力。我们的团队将这些视为不可分割的目标。 尽管有令人信服的证据证明将健康的社会决定者作为基本的影响 疾病的原因，这项工作的较少是基于实际的干预措施和行动，甚至更少 与癌症事件有关的工作。为了在持续的贫困地区建立预防能力，这是科学的 研究需要与这些社区共同制作，以产生最大的影响，并 研究与方法核心将在我们中心的这一任务中发挥作用。