Core B: Biostatistics and Data Harmonization Shared Resource

核心 B：生物统计学和数据协调共享资源

基本信息

批准号：
10658909
负责人：
Charles Quesenberry
金额：
$ 13.96万
依托单位：
KAISER FOUNDATION RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-15 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10658909
关键词：
Accident and Emergency department Address Adolescent and Young Adult Adolescent and young adult cancer patients Affect Ambulatory Surgical Procedures Biometry Biostatistics Shared Resource California Cancer Survivor Caring Clinical Clinical Data Consultations Continuity of Patient Care Data Data Analyses Data Linkages Data Reporting Data Set Data Sources Development Disease Emergency Situation Ensure Etiology Foundations Goals Guidelines Health Planning Health Resources Healthcare Healthcare Systems Hospitalization Human Resources Individual Information Systems Integrated Health Care Systems Investigation Knowledge Late Effects Leadership Link Malignant Neoplasms Measures Methods North Carolina Outcome Patient Outcomes Assessments Patients Phase Population Predictive Factor Public Health Registries Research Research Activity Research Design Research Personnel Resource Sharing Resources Risk Factors Sampling Selection Bias Services Source Standardization Statistical Methods Surveys Survivors Systematic Bias Universities Utah Variant Weight administrative database adverse outcome cancer care clinical care clinical database clinical encounter cohort cost effectiveness data harmonization data management design expectation experience improved inclusion criteria insight member neoplasm registry population health preference public health intervention

项目摘要

ABSTRACT – Core B, Biostatistics and Data Harmonization Shared Resource Strong biostatistical leadership and expertise are integral to achieving scientific integrity of research data and analytical results, and are indispensable for assuring confidence in the potential clinical or public health impact of research activities. The primary goal of Core B, the Biostatistics and Data Harmonization Shared Resource, is to oversee and guide all aspects of study design, data management and data analysis across all three P01 projects so the scientific aims of each project are addressed using standardized, high- quality datasets and the most appropriate statistical methods. We have a strong team of biostatisticians, programmer/analysts and investigators with extensive experience using the P01 data and population resources. Our resources include the California and Utah Cancer Registries linked to hospitalization, emergency and ambulatory surgery data; the University of North Carolina at Chapel Hill Cancer Information & Population Health Resource; the integrated healthcare systems of Kaiser Permanente Northern California and Southern California; and survey data on a population subset. The varying data sources present several challenges in cleaning, analysis and interpretation, including the potential for reverse causation and various forms of selection bias. Biostatistical consultation provided by the Core will ensure the appropriate application of approaches to determine the potential magnitude of such biases and methods to account for them. The specific aims of the Core are to: 1. Provide overall biostatistical leadership, consultation and support across all three P01 projects and Core C, the Survey Shared Resource; 2. Carry out cohort identification to meet the subject inclusion criteria for each aim of each project and for the survey described in Core C; 3. Harmonize and standardize variable definitions used across data sources and projects; 4. Construct and provide study analytic datasets that incorporate data from clinical and administration data sources, cancer registries, and patient surveys; 5. Oversee analyses using appropriate methods to achieve the aims of each project, including consideration of systematic biases, potential confounders, and sampling weights in the analysis of survey data. To carry out the objectives of this P01, centralized biostatistical expertise and services will ensure use of common concepts and data definitions throughout the P01. This Core will ensure that data are appropriate for the questions addressed, harmonized across source data systems to enhance comparability, and analyzed and interpreted with knowledge of strengths and limitations. This strategy will maximize the potential impact of P01 findings to inform and improve healthcare for adolescent and young adult cancer survivors.

摘要 - 核心B，生物统计学和数据协调共享资源强大的生物统计领导力和专业知识是实现研究科学完整性不可或缺的一部分数据和分析结果，对于确保对潜在临床或公众的信心是必不可少的研究活动的健康影响。核心B的主要目标，生物统计学和数据协调共享资源是在海外和指导研究设计，数据管理和数据分析的各个方面在所有三个P01项目中质量数据集和最合适的统计方法。我们有一个强大的生物统计学家，使用P01数据和人群具有丰富经验的程序员/分析师和研究人员资源。我们的资源包括与住院有关的加利福尼亚和犹他州癌症注册机构，急诊和门诊手术数据；北卡罗来纳大学教堂山癌症信息和人口健康资源； Kaiser Permanente North California和南加州；和人口子集的调查数据。不同的数据源显示了几个清洁，分析和解释方面的挑战，包括逆向因果和各种的潜力选择偏见的形式。核心提供的生物统计咨询将确保适当的申请确定此类偏见和方法的潜在幅度的方法。核心的具体目的是： 1。在所有三个P01项目中提供总体生物统计领导，咨询和支持 Core C，调查共享资源； 2。执行队列识别，以满足每个项目的每个目标的主题纳入标准 Core C中描述的调查； 3.在数据源和项目中使用并标准化变量定义； 4。构建并提供研究分析数据集，以结合临床和管理的数据数据源，癌症注册表和患者调查； 5。使用适当的方法监督分析，以实现每个项目的目标，包括在分析中考虑系统偏见，潜在的混杂因素和抽样权重调查数据。为了实现此P01的目标，集中的生物统计学专业知识和服务将确保使用整个P01的常见概念和数据定义。该核心将确保数据合适对于解决的问题，跨源数据系统进行了协调以增强可比性和分析并以优势和局限性的知识来解释。该策略将最大化 P01的发现，以告知和改善青少年和年轻成人癌症生存的医疗保健。