Cognitive Impairment in Chronic Rhinosinusitis

慢性鼻窦炎的认知障碍

• 批准号: 10659054
• 负责人: Mahboobeh Mahdavinia
• 金额: $ 7.9万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-04 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10659054
• 关键词: Acceleration; Adult; Affect; Age; Aging; Allergic; American; Assessment tool; Asthma; Biological Markers; Blood specimen; Case/Control Studies; Chronic; Circadian Rhythms; Cognition; Cognitive; Data; Development; Disease; Feasibility Studies; Financial Hardship; Future; Goals; Grant; Health; Impaired cognition; Impairment; Individual; Inflammation; Inflammatory; Interdisciplinary Study; Interleukin 6 Receptor; Interleukin-6; Intervention Studies; Judgment; Language; Lead; Learning; Link; Measures; Mediating; Mediation; Memory; Methods; Outcome; Patients; Pilot Projects; Polysomnography; Process; Quality of life; Questionnaires; Regression Analysis; Research; Research Personnel; Respiratory Disease; Respiratory System; Risk; Risk Factors; Role; Series; Serum; Severities; Sleep; Sleep Disorders; Sleep disturbances; Societies; Statistical Models; Study Subject; Testing; Thinking; Time; Training Support; United States; Work; actigraphy; adverse outcome; atopy; chronic rhinosinusitis; cognitive function; cognitive testing; cohort; comorbidity; comparison control; cost; cytokine; data acquisition; demographics; experience; improved; modifiable risk; participant enrollment; physical conditioning; prevent; recruit; respiratory; skills; sleep onset; socioeconomics

Abstract Cognitive impairment is characterized by problems with memory, language, thinking or judgment. Despite the tremendous known impact of impaired cognition on quality of life and individuals' health, beside our pilot study; impaired cognitive function associated with sleep timing disruption as its potential mechanisms, has not been objectively investigated in patients with inflammatory and allergic respiratory diseases such as Chronic rhinosinusitis (CRS). Our KL-2 supported studies and preliminary data have shown significant cognitive impairment in CRS patients compared to controls that was associated with sleep disturbance and sleep timing changes. Leveraging experienced gained through my KL2, the overall objectives of this proposed study are to: (1) characterize cognitive function profile in both healthy controls and patients with chronic inflammation in upper airways ; and identify those at risk of impaired cognition; (2) identify the preventable risk factors of cognitive impairment including sleep timing shift, (3) test the hypothesis that serum IL-6 has a role in this process and may serve as a biomarker for cognitive impairment in CRS. We have already recruited 124 individuals (69 CRS and 55 controls) for our pilot data and will plan to recruit additional study subjects and complete the data acquisition for all these cases to perform a case control study of 100 CRS patients and 100 controls. Aim 1 will characterize the cognitive function profile analyzing 6 domains of cognitive function in this case-control study of patients with CRS of varied severity compared to matched healthy controls; and also aims to identify risk factors of cognitive impairment in CRS. The potential risk factors we plan to study include demographics, socioeconomic and CRS-severity factors; and CRS-related comorbidities (atopy, asthma, etc.). Aim 2 focuses to test the hypothesis that a sleep-timing shift is linked to cognitive function impairment in CRS. Objective measurements of sleep timing including 7 days actigraphy and circadian rhythm assessment questionnaires will be performed in above 100 CRS and 100 control patients. A four-step statistical approach in which a series of regression analysis are conducted will be applied to test whether the effect of CRS severity on cognitive function is mediated by sleep. Aim 3 focuses to test the hypothesis that serum IL-6 is a valid biomarker for cognitive impairment in CRS. For this aim serum IL-6 level will be determined and related to cognitive variables in patients, using a multi-variate statistical model. If IL-6 is found to have a significant mediation, then sleep variables will be added in the regression analysis to explore how they work together to affect the association between IL-6 and cognition. Other inflammatory cytokines and soluble IL-6 receptor will also be measured to test related hypotheses.

抽象的 认知障碍的特征是记忆，语言，思维或判断问题。 尽管认知受损对生活质量和个人的巨大影响 健康，除了我们的试点研究；与睡眠时间中断相关的认知功能受损 作为其潜在机制，尚未客观地研究炎症患者 和过敏性呼吸道疾病，例如慢性鼻孔炎（CRS）。我们的KL-2支持 研究和初步数据显示CRS患者的认知障碍很大 与与睡眠障碍和睡眠时间变化相关的对照相比。 利用我的KL2获得的经验，这项拟议研究的总体目标是 至：（1）在健康对照和慢性患者中表征认知功能曲线 上呼吸道的炎症；并确定有认知受损的风险的人； （2）确定 可预防的认知障碍危险因素，包括睡眠时间移位，（3）测试 假设血清IL-6在此过程中起作用，并且可以作为认知的生物标志物 CRS的损害。 我们已经为我们的飞行员数据招募了124个人（69个CR和55个对照），并将 计划招募其他研究主题，并完成所有这些情况的数据获取 对100名CRS患者和100例对照进行案例对照研究。 AIM 1将表征认知函数概况分析6个认知功能的域 与匹配的健康相比，对严重程度不同的患者的病例对照研究 控件；并且旨在确定CRS认知障碍的危险因素。潜在风险 我们计划研究的因素包括人口统计学，社会经济和CRS-严重性因素；和 与CRS相关的合并症（特应性，哮喘等）。 AIM 2重点是测试以下假设，即睡眠转变与认知功能有关 CRS的损害。睡眠时机的客观测量，包括7天的行为和 昼夜节律评估问卷将在100多个CR和100个控制中进行 患者。进行了一系列回归分析的四步统计方法 将应用于测试CRS严重程度对认知功能的影响是否由 睡觉。 AIM 3重点是检验血清IL-6是认知障碍的有效生物标志物的假设 在CRS中。对于此目的，将确定血清IL-6级，并与认知变量有关 患者，使用多变量统计模型。如果发现IL-6具有显着的调解， 然后在回归分析中添加睡眠变量，以探索它们如何一起工作 影响IL-6和认知之间的关联。其他炎症细胞因子和可溶性 IL-6受体也将测量以检验相关假设。