OCT Angiography for Age-related Macular Degeneration

OCT 血管造影检查年龄相关性黄斑变性

• 批准号: 10660875
• 负责人: Steven T Bailey
• 金额: $ 68.43万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10660875
• 关键词: Affect; Age Years; Age related macular degeneration; Algorithms; Anatomy; Angiography; Architecture; Area; Artificial Intelligence; Biological Markers; Blindness; Blood Vessels; Blood capillaries; Blood flow; Cardiovascular system; Characteristics; Choroidal Neovascularization; Clinical Research; Compensation; Computational algorithm; Cross-Sectional Studies; Defect; Detection; Development; Devices; Diagnosis; Disease Progression; Drusen; Elderly; Evaluation; Exudate; Exudative age-related macular degeneration; Eye; Eye diseases; Future; Goals; Grant; Image; Lateral; Length; Lobular; Location; Longitudinal Studies; Measurement; Measures; Methods; Monitor; Morphologic artifacts; Noise; Nonexudative age-related macular degeneration; Optical Coherence Tomography; Pathogenesis; Perfusion; Persons; Photoreceptors; Resolution; Retina; Risk; Risk Factors; Role; Sampling; Scanning; Sensitivity and Specificity; Series; Signal Transduction; Source; Speed; Structure of retinal pigment epithelium; System; Technology; Testing; Time; Vascular Endothelial Growth Factors; Vision; Visualization; Work; advanced analytics; analytical method; analytical tool; attenuation; choroidal circulation; deep learning; density; feature extraction; geographic atrophy; geographic risk; high risk; improved; innovation; interest; macula; novel; novel marker; prevent; prototype; reconstruction; retina blood vessel structure; retina circulation; retinal imaging; success; treatment response

PROJECT SUMMARY Age-related macular degeneration (AMD) is an eye disease leading to permanent central vision loss. Our prior work focused on using optical coherence tomographic angiography (OCTA) in the diagnosis and management of choroidal neovascularization (CNV), the characteristic feature of exudative AMD. Our clinical studies have shown OCTA has high sensitivity and specificity for CNV detection when evaluated by clinicians and artificial intelligence; we have developed novel CNV quantitative metrics to monitor treatment response; and, have shown OCTA can identify non-exudative CNV that carries a high risk for developing exudation. Though exudative AMD is treatable, many eyes under treatment will lose vision due to developing advanced dry AMD, characterized by geographic atrophy (GA). There is great interest in using OCTA to detect perfusion defects in the choriocapillaris and retinal DCP that could serve as biomarkers for eyes at risk for developing advanced AMD prior to vision loss. We will accomplish these goals with the following aims and evaluations: Aim 1: Improve imaging of the choriocapillaris and deep capillary plexus (DCP). Our high-speed swept-source (SS)-OCT prototype has shown superior resolution compared to other OCTA devices. However, several issues currently still prevent clean visualization of deep vascular layers on 9×9-mm scans at the central macula. We will address these issues by optimizing scan sampling density, improving the OCTA computation algorithm, and developing a new projection resolution algorithm that is effective in these layers. Aim 2: Develop quantitative analysis of choriocapillaris and deep capillary plexus perfusion defects. Imaging capillaries in deeper anatomic layers is difficult due to signal attenuation and background noise. To compensate for these effects, we will improve avascular area measurements by including a capillary reconstruction strategy in the pre-processing steps. We will also develop a novel flow defect measurement by combining the structural OCT and OCTA signals that will be able to identify non-perfused capillary segments. Aim 3: Evaluate advanced OCTA for AMD in clinical studies. Three clinical studies will test three advanced OCTA-derived biomarkers: choriocapillaris avascular area, DCP avascular areas, and non-perfused capillary length in the DCP. (1) Conduct a cross-sectional study to determine if the advanced OCTA biomarkers are associated with increasingly advanced stages of AMD. (2) Conduct a longitudinal study that evaluates eyes with intermediate AMD to determine if advanced OCTA biomarkers can identify eyes at risk factors for developing advanced AMD. (3) Conduct a longitudinal study of eyes with exudative AMD under treatment, to determine if the advanced OCTA biomarkers will predict eyes at risk for developing GA. If successful, OCTA will enable a better understanding of the role of choriocapillaris and DCP in AMD pathogenesis and will help predict eyes at risk for developing advanced AMD. The innovations presented here will allow OCTA technology to fulfill its potential by providing highly detailed images and measurements of vasculature throughout the retina and choriocapillaris.

项目摘要 与年龄相关的黄斑变性（AMD）是一种眼科疾病，导致永久性中央视力丧失。我们的先验 专注于在诊断和管理中使用光学连贯性层析成像（OCTA）的工作 脉络膜新生血管（CNV），成人AMD的特征。我们的临床研究有 临床医生和艺术评估时，显示的八颗CNV对CNV检测具有高灵敏度和特异性 智力;我们已经开发了新型的CNV定量指标来监测治疗反应。并且，已显示 Octa可以识别出具有高渗出剂风险的非估算性CNV。虽然极端AMD 可以治疗，许多受到治疗的眼睛会因发展为高级干燥AMD而失去视力，其特征是 地理萎缩（GA）。有兴趣使用八粒检测绒毛膜中的灌注缺陷 和视网膜DCP，可以用作生物标志物，以使眼睛有风险在视力之前发展高级AMD 损失。我们将通过以下目标和评估来实现这些目标：目标1：改进成像 绒毛膜毛细血管和深毛细血管（DCP）。我们的高速扫掠源（SS）-OCT原型具有 与其他八八个设备相比，分辨率优越。但是，目前仍然有几个问题可以防止清洁 在中央黄斑处的9×9毫米扫描上的深血管层的可视化。我们将通过 优化扫描采样密度，改善八八计算算法并开发新的投影 在这些层中有效的分辨率算法。目标2：开发绒毛膜毛毛皮的定量分析 和深毛细血管灌注缺陷。由于更深的解剖层中的成像毛细血管很难 信号衰减和背景噪声。为了弥补这些影响，我们将改善血管区域 通过在预处理步骤中包括毛细管重建策略来测量。我们还将发展 通过结合结构OCT和八八个信号的新型流缺陷测量 非毛细管段。 AIM 3：评估临床研究中AMD的高级八颗。三个临床 研究将测试三个先进的八源生物标志物：绒毛膜毛细血管血管区域，DCP血管 DCP中的区域和非毛细管长度。 （1）进行横断面研究，以确定是否是否 高级八八生物标志物与AMD的高级阶段越来越高。 （2）进行 纵向研究，评估具有中间AMD的眼睛，以确定高级八颗生物标志物是否可以 识别出开发高级AMD的风险因素的眼睛。 （3）对极端的眼睛进行纵向研究 AMD正在接受治疗，以确定高级八颗生物标志物是否会预测眼睛有发展的风险 GA。如果成功的话，八章将可以更好地理解Choriocapillaris和DCP在AMD中的作用 发病机理，将有助于预测患有晚期AMD的风险。这里提出的创新 通过提供高度详细的图像和测量值 整个视网膜和绒毛膜的脉管系统。

项目成果

Filling gaps in asymmetric hydrogenation methods for acyclic stereocontrol: application to chirons for polyketide-derived natural products.

• DOI: 10.1021/ar200145q
• 发表时间: 2012-10
• 期刊: Accounts of chemical research
• 影响因子: 18.3
• 作者: Ye Zhu;K. Burgess

Optimization of the split-spectrum amplitude-decorrelation angiography algorithm on a spectral optical coherence tomography system.

• DOI: 10.1364/ol.40.002305
• 发表时间: 2015-05-15
• 期刊: Optics letters
• 影响因子: 3.6
• 作者: Gao SS;Liu G;Huang D;Jia Y
• 通讯作者: Jia Y

High dynamic range optical coherence tomography angiography (HDR-OCTA).

• DOI: 10.1364/boe.10.003560
• 发表时间: 2019-06
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Xiang Wei;T. Hormel;Shaohua Pi;Yukun Guo;Y. Jian;Yali Jia

Optical coherence tomography angiography in pediatric choroidal neovascularization.

光学相干断层扫描血管造影在小儿脉络膜新生血管中的应用。

• DOI: 10.1016/j.ajoc.2016.03.009
• 发表时间: 2016
• 期刊: American journal of ophthalmology case reports
• 作者: Veronese,Chiara;Maiolo,Chiara;Huang,David;Jia,Yali;Armstrong,GraysonW;Morara,Mariachiara;Ciardella,AntonioP
• 通讯作者: Ciardella,AntonioP

75-degree non-mydriatic single-volume optical coherence tomographic angiography.

• DOI: 10.1364/boe.10.006286
• 发表时间: 2019-11
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Xiang Wei;T. Hormel;Yukun Guo;Yali Jia