Olfactory Dysfunction in Aging Adults

老年人的嗅觉障碍

• 批准号: 10660971
• 负责人: RODNEY JON SCHLOSSER
• 金额: $ 41.71万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10660971
• 关键词: Adult; Affect; Age; Age Years; Aging; Anatomy; Anosmia; Area; Biological Markers; Body Weight Changes; Characteristics; Classification; Clinical; Cognition; Data; Demographic Factors; Desire for food; Development; Diagnostic; Dimensions; Disease; Elderly; Elements; Endoscopy; Enrollment; Food; Functional disorder; Funding; Future; Health; Health Surveys; Hygiene; Impairment; Individual; Longitudinal cohort study; Magnetic Resonance Imaging; Measures; Mental Depression; Methodology; Methods; Modeling; Moods; Mucous body substance; Nasal cavity; National Institute on Deafness and Other Communication Disorders; Natural History; Olfactory Nerve; Olfactory Pathways; Olfactory dysfunction; Outcome Measure; Pathology; Patient Outcomes Assessments; Patients; Peripheral; Persons; Phenotype; Population; Predictive Factor; Prognostic Factor; Prospective, cohort study; Proteins; Protocols documentation; Psychophysics; Quality of life; Radiology Specialty; Reporting; Research; Research Design; Safety; Site; Smell Perception; Social Interaction; Social isolation; Strategic Planning; Structure; Techniques; Testing; Therapeutic; Time; Variant; Visual; analog; central gray matter; clinical phenotype; clinically relevant; cognitive function; cognitive testing; comorbidity; cooking; cribriform plate; demographics; hearing impairment; improved; insight; interest; mortality; neuroepithelium; nutrition; olfactory receptor; personalized medicine; population health; prevent; prospective; psychosocial; screening; sex; specific biomarkers; white matter

PROJECT SUMMARY/ABSTRACT: Olfactory dysfunction (OD) has been reported in more than 50% of older adults and is strongly associated with 5 year mortality. Unfortunately, a key weakness of prior research on OD in aging is that it comes primarily from broad population health surveys using limited screening tests for OD. The result is that currently there are no methods for organizing patients with OD in aging based on either disease site or mechanism. Various anatomic sites along the olfactory pathway may be involved in OD in aging, including the nasal cavity, olfactory neuroepithelium, olfactory nerves, cribriform plate, and central olfactory structures. At these anatomic sites, OD then likely occurs through distinct mechanisms that will be associated with unique olfactory-specific biomarkers. Although prior studies have been instrumental in demonstrating that OD is highly prevalent in older individuals, most were not designed to comprehensively evaluate the olfactory- specific measures that would allow classification into subtypes of OD. Our hypothesis is that patients with OD in aging can be grouped into clinically relevant phenotypes based on anatomic sites of dysfunction that will provide important mechanistic insights. Our long term objective is to develop better diagnostic protocols and personalized treatments for patients with OD in aging. However, in order to develop targeted treatments one must first be able to classify patients based on the underlying site of disease and likely mechanism. This hypothesis will be tested using the following Aims: 1) Establish reliable and clinically relevant phenotypes of OD in older adults, 2) Determine the impact of OD on health and quality of life (QOL) in older adults, and 3) Determine which baseline factors predict olfactory changes over time in older adults. The National Institute on Deafness and Other Communication Disorders has a stated its interest in this area, “as the population ages, (to) determine how many more people report…smell problems that affect quality of life.” This proposal will improve our understanding of clinical classifications, mechanisms, QOL impact and natural history of OD in older adults and lay the groundwork for future studies examining therapeutic options to prevent, delay the onset or treat OD in aging.

项目摘要/摘要： 据报道，超过50％的老年人已经报道了嗅觉功能障碍（OD），并且很强 与5年死亡率有关。不幸的是，先前研究OD的关键弱点 衰老是它主要来自使用有限筛查测试的广泛人口健康调查 对于OD。结果是目前尚无组织OD患者在衰老中的方法 基于疾病部位或机制。沿嗅觉途径的各种解剖站点 可能参与OD的衰老，包括鼻腔，嗅觉神经皮质，嗅觉 神经，环形板和中央嗅觉结构。在这些解剖部位，OD可能 通过与独特的特定嗅觉特异性相关的不同机制发生 生物标志物。尽管先前的研究一直在证明OD高度发挥作用 在老年人中普遍存在，大多数并非旨在全面评估嗅觉 - 将允许分类为OD亚型的特定措施。我们的假设是 衰老中的OD患者可以根据基于临床相关的表型分为 功能障碍的解剖部位将提供重要的机械见解。我们的漫长 术语目标是为患者制定更好的诊断方案和个性化治疗 与OD衰老。但是，为了开发目标治疗，必须首先能够 根据疾病的潜在部位和可能的机制对患者进行分类。这个假设 将使用以下目的进行测试：1）建立可靠且与临床相关的表型 老年人的OD，2）确定OD对老年人健康和生活质量（QOL）的影响 成人和3）确定哪些基线因子预测嗅觉随着时间的变化而变化 成年人。美国国家聋哑和其他沟通障碍研究所已经说明了它的 对这一领域的兴趣，“随着人口的年龄，（要）确定有多少人报告……闻起来 影响生活质量的问题。”该建议将改善我们对临床的理解 老年人中OD的分类，机制，质量质量影响和自然历史，并放置 未来研究的基础研究检查治疗方案，以防止，延迟发作或治疗 OD衰老。

项目成果

Adverse events associated with budesonide nasal irrigation reported to the US Food and Drug Administration: 2007 to 2022.

向美国食品和药物管理局报告的与布地奈德鼻腔冲洗相关的不良事件：2007 年至 2022 年。

• DOI: 10.1002/alr.23232
• 发表时间: 2024
• 期刊: International forum of allergy & rhinology
• 影响因子: 6.4
• 作者: Rathi,VinayK;Sawicki,NicholasW;Schlosser,RodneyJ;Soler,ZacharyM;Scangas,GeorgeA;Workman,AlanD;Gray,StaceyT
• 通讯作者: Gray,StaceyT

Unsupervised Clustering of Olfactory Phenotypes.

嗅觉表型的无监督聚类。

• DOI: 10.1177/19458924221114255
• 发表时间: 2022
• 期刊: American journal of rhinology & allergy
• 影响因子: 2.6
• 作者: Schlosser,RodneyJ;Dubno,JudyR;Eckert,MarkA;Benitez,AndreanaM;Gregoski,Matthew;Ramakrishnan,Viswanathan;Matthews,Lois;Soler,ZacharyM
• 通讯作者: Soler,ZacharyM