UNC Research Training Program in Respiratory Diseases and Critical Care

北卡罗来纳大学呼吸系统疾病和重症监护研究培训计划

• 批准号: 10714527
• 负责人: Richard Charles Boucher
• 金额: $ 52.69万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10714527
• 关键词: Critical Care; Research Training; Respiratory Disease; Training Programs

Project Summary/Abstract This proposal for a new T32 Program titled “UNC Research Training Program in Respiratory Diseases and Critical Care” at The University of North Carolina-Chapel Hill supports 6 postdoctoral trainees with M.D., M.D./Ph.D. or Ph.D. degrees for research training in lung disease, emphasizing a joint training program for Medicine and Pediatric trainees. The Program provides multidisciplinary training in basic, translation and clinical research within the pulmonary and critical care divisions of the Departments of Medicine and Pediatrics and our three Research Centers devoted to understanding lung health and disease. Our Program offers a Training Faculty of 48 trainers (38 mentors, 8 junior mentors and 2 co-mentors) from 7 clinical (2) and basic science (5) departments in the School of Medicine. M.D. trainees will enter at years 3-5 in their clinical and research training, designed to provide them with skills required for a leadership career in academic pulmonary medicine. Ph.D. trainees will typically enter in the second year of their post-doctoral fellowship, and they will be well integrated into the basic, translational and clinical aspects of their project. Each trainee will have a scholarly oversight committee that includes mentors from varying disciplines who will facilitate their scientific growth and career development, including grant writing and leadership skills. Each trainee will be welcomed into a DEI culture, will take workshops, and will become embedded in this culture. Each area of lung research is multidisciplinary in nature and emphasizes a broader knowledge of the basic, translational, clinical and impact implications for each trainee's question. Areas of research include cystic fibrosis, primary ciliary dyskinesia, idiopathic bronchiectasis, cell and molecular biology of airway epithelia in health and disease, leukocyte kinetics and clinical research in COPD, control of airway inflammation, inflammatory and innate immune responses during ARDS and bacterial and viral infections, clinical trials, comparative effectiveness research, analyses of qualitative narrative data, and large cohort studies in critical care, basic and translational proteomics of airways and alveoli, the airway microbiome in health and disease, the responses to injury by physical, chemical, and microbial environmental agents, and clinical and basic science studies in asthma. Novel programs that exemplify the multi-disciplinary nature include ARDS and Critical Care Research, the CF Research Program, and Combustion-induced Bronchitis in the Military, each of which require cross-disciplinary interactions amongst a wide range of expertise to accomplish their goals. Clinical studies will be integrated with basic observations using translational physiologic, biochemical, molecular and genetic technologies, and -omics approaches and will provide training in state-of-the-art –omics and other basic technologies, bioinformatics, database design, use and analyses, and statistical interpretation. Emphasis is on mechanisms underlying lung diseases in pediatric and adult populations and development of novel therapeutic strategies. Our Program provides an opportunity for trainees to develop as scientists and become independent investigators and leaders within the national community.

项目概要/摘要 这项名为“北卡罗来纳大学呼吸系统疾病研究培训计划”的新 T32 计划提案 北卡罗来纳大学教堂山分校的“重症监护”项目为 6 名医学博士后培训生提供支持， 肺部疾病研究培训的医学博士/博士或博士学位，强调联合培训计划 该计划为医学和儿科学员提供基础、翻译和临床方面的多学科培训。 医学和儿科的肺部和重症监护部门的研究以及我们的 三个致力于了解肺部健康和疾病的研究中心我们的计划提供培训。 由来自 7 个临床 (2) 和基础科学 (5) 的 48 名培训师组成（38 名导师、8 名初级导师和 2 名副导师） 医学博士学员将在第 3 至第 5 年级接受临床和研究培训， 旨在为他们提供学术肺医学博士学位所需的领导职业技能。 学员通常会在博士后研究的第二年进入，他们将很好地融入 每位学员都将受到学术监督。 委员会包括来自不同学科的导师，他们将促进他们的科学成长和职业生涯 发展，包括资助写作和领导技能，每位学员都将受到 DEI 文化的欢迎。 参加研讨会，并将融入这种文化中。肺研究的每个领域都是多学科的。 性质，并强调对每个问题的基本、转化、临床和影响影响有更广泛的了解 学员的问题包括囊性纤维化、原发性纤毛运动障碍、特发性支气管扩张、 健康和疾病中气道上皮的细胞和分子生物学、白细胞动力学和临床研究 COPD、控制气道炎症、ARDS 期间的炎症和先天免疫反应以及细菌 和病毒感染、临床试验、比较有效性研究、定性叙述数据分析，以及 重症监护、气道和肺泡的基础和转化蛋白质组学、气道的大型队列研究 健康和疾病中的微生物组，对物理、化学和微生物环境损伤的反应 代理，以及哮喘的临床和基础科学研究。 自然包括 ARDS 和重症监护研究、CF 研究计划和燃烧引起的 军队中的支气管炎，每一种都需要广泛的专业知识之间的跨学科互动 为了实现他们的目标，将使用转化将临床研究与基本观察相结合。 生理学、生化、分子和遗传技术以及组学方法，并将提供培训 最先进的组学和其他基础技术、生物信息学、数据库设计、使用和分析，以及 重点是儿童和成人肺部疾病的机制。 我们的计划为学员提供了发展的机会。 作为科学家并成为国家社会内的独立调查员和领导者。