Core 1: Biostatistics & Bioinformatics Core

核心1：生物统计学

基本信息

批准号：
10716157
负责人：
LYNNE R WILKENS
金额：
$ 24.94万
依托单位：
UNIVERSITY OF HAWAII AT MANOA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-19 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10716157
关键词：
Archives Asian Americans Attitude Bayesian Method Behavioral Bioinformatics Biologic Characteristic Biological Markers Biometry Breast Cancer Prevention Breast Cancer Risk Assessment Tool Breast Cancer Risk Factor Calibration Collection Communities Computer software DNA Methylation DNA Sequence Alteration Data Data Analyses Data Collection Data Security Deposition Development Dietary Intervention Ensure Equipment and supply inventories Ethnic Population Fatty acid glycerol esters Fibrosis Funding Gene Expression Goals Guidelines Hawaii Individual Information Systems Informed Consent Intention Liver Malignant Neoplasms Malignant neoplasm of lung Mammography Manuscripts Minority Health Research Modeling Molecular Native Hawaiian Native Hawaiian or Other Pacific Islander Obesity Outcome Pacific Islands Patients Performance Population Population Heterogeneity Preparation Prevalence Prevention Primary carcinoma of the liver cells Process Prognosis Randomized Research Research Design Research Personnel Research Project Grants Retrieval Risk Sampling Schedule Security Structure Techniques Tissue Banks Tissues Translational Research Tumor Subtype Tumor Tissue Woman cancer health disparity cancer risk career cohort computerized data processing data integration data management data quality data resource data sharing database of Genotypes and Phenotypes design dietary adherence dietary restriction disparity reduction efficacy testing experience genome-wide health equity high risk improved liver stiffness lung cancer screening malignant breast neoplasm mammography registry methylation biomarker minority health minority health disparity multi-ethnic non-alcoholic fatty liver disease novel programs radiomics randomized, clinical trials recruit repository risk prediction model screening sharing platform tool tumor tumor registry

项目摘要

SUMMARY / ABSTRACT The goal of the Biostatistics and Bioinformatics Core (BBC) is to provide support to the SPORE projects, other cores, as well as the researchers funded through the Developmental Research Program or Career Enhancement Program in all aspects of study design and data management, processing, integration and analysis. This proposal focuses on translational research in minority health and health equity in cancer for the diverse populations of Hawaii, particularly the understudied Asian American, Native Hawaiian and Pacific Islander (AANHPI) groups. Project 1 will focus on prevention of hepatocellular carcinoma, for which Hawaii’s AANHPI populations are at high risk, by evaluating, in a randomized clinical trial, the efficacy of an intermittent energy restriction on reducing liver fat and liver stiffness in non-alcoholic fatty liver disease (NAFLD) with predicted fibrosis stage 2+. Project 2 will focus on reducing the disparity for lung cancer among Native Hawaiians through elucidation of the behavioral aspects of, and improved guidelines for, screening and the biological characteristics of this malignancy in this population. Project 3 will focus on breast cancer prevention among AANHPI women through calibration and addition of mammography radiomic features, associated with prognosis and adiposity, to commonly used breast cancer risk models (e.g., Gail model). The BBC is staffed by a team experienced in biostatistics and bioinformatics for translational research in multiethnic populations. Provision of the highest quality support will be facilitated by having the expertise concentrated in the Core rather than in individual projects, as this will lead to sharing of ideas and tools. The aims of the core are: 1) to provide support for data management and integration for the projects, while ensuring data quality and security processes are incorporated, 2) to develop and execute study design and analysis plans for each of the research projects, in conjunction with Project Leaders, and 3) to facilitate data sharing among SPORE researchers and with the research community. We will ensure that the most appropriate and rigorous data collection, management and analysis approaches are used, that the flow of data and material is seamless, and that requirements for data governance, security, and sharing are met. In addition, we will explore novel techniques, such as integrative clustering and Bayesian methods for combining omics data, to better understand the underlying mechanisms. The BBC as a single locus for these comprehensive activities will provide efficiency, integration and scientific rigor that are not otherwise available.

摘要/摘要生物统计学和生物信息学核心 (BBC) 的目标是为 SPORE 项目提供支持，其他核心，以及通过发展研究计划或职业资助的研究人员研究设计和数据管理、处理、集成和各个方面的增强计划该提案重点关注少数群体健康和癌症健康公平的转化研究。夏威夷的不同人群，特别是受研究的亚裔美国人、夏威夷原住民和太平洋人岛民 (AANHPI) 小组的项目 1 将重点关注肝细胞癌的预防，夏威夷的该项目是针对该项目的。通过在一项随机临床试验中评估间歇性治疗的有效性，AANHPI 人群处于高风险状态。能量限制可减少非酒精性脂肪肝 (NAFLD) 患者的肝脏脂肪和肝脏硬度预测纤维化阶段 2+ 项目 2 将重点关注减少夏威夷原住民患肺癌的差异。通过阐明筛查和生物学的行为方面并改进指南项目 3 将重点关注该人群中乳腺癌的预防。 AANHPI 女性通过校准和添加与预后相关的乳房 X 线摄影放射组学特征和肥胖，到常用的乳腺癌风险模型（例如盖尔模型），BBC 拥有一个团队。在多种族人群的转化研究方面拥有丰富的生物统计学和生物信息学经验。通过将专业知识集中在核心而不是其他领域，将有助于提供最高质量的支持个人项目，因为这将导致想法和工具的共享。核心的目标是：1）提供支持。用于项目的数据管理和集成，同时确保数据质量和安全流程合并，2）为每个研究项目制定和执行研究设计和分析计划，与项目负责人合作，以及 3) 促进 SPORE 研究人员之间以及与我们将确保最适当和严格的数据收集、管理和研究社区。使用分析方法，数据和材料的流动是无缝的，并且对数据的要求此外，我们将探索新的技术，例如集成。聚类和贝叶斯方法结合组学数据，以更好地理解底层机制。 BBC 作为这些综合活动的单一场所，将提供效率、整合性和科学性严密性是其他方式无法获得的。