Comp C Spina Bifida Urologic Protocol at Vanderbilt Children's Hospital

范德比尔特儿童医院的 Comp C 脊柱裂泌尿科治疗方案

• 批准号: 10655383
• 负责人: Douglass Brooks Clayton
• 金额: $ 2.5万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10655383
• 关键词: Comp; Spina; Bifida; Urologic; Protocol

PROJECT SUMMARY Advances in medical care have increased longevity for babies born with spina bifida, the most common permanently disabling birth defect in the United States. The main goals of the urologist participating in the care or patients with spina bifida are: 1) to preserve normal renal function and 2) to ensure adequate bladder continence for enhancing self-esteem and independence. Despite these common goals, practice patterns vary, and best practices are not well defined. The Urologic Management to Preserve Initial Renal Function Protocol (UMPIRE) has been designed to evaluate outcomes on a standardized urologic protocol from the neonatal period to 10 years of age. The Spina Bifida Program at Monroe Carell Jr. Children's Hospital at Vanderbilt (MCJCHV) evaluates approximately 20 newborns with spina bifida each year. The pediatric urology division at MCJCHV has set the following goals for this study: 1) to approach each eligible patient in our program for enrollment, 2) to contribute longitudinal data on diagnostic studies and interventions as specified by the protocol, and 3) to evaluate data from UMPIRE to answer hypothesis-driven questions specifically about clinical predictors for hostile videourodynamics and decreased renal function. The PI along with the clinical research coordinator will ensure quality control of data submitted to the CDC. The PI has a demonstrated record of productive research UMPIRE. Published results from this study will help to inform best practice clinical guidelines for urologic management in the child with spina bifida

项目摘要 医疗服务的进步增加了患有脊柱裂的婴儿的寿命，这是最常见的 在美国永久性禁用先天缺陷。泌尿科医生参与护理的主要目标 或脊柱裂的患者为：1）保留正常的肾功能和2）确保足够的膀胱 增强自尊和独立性的推进。尽管有这些共同的目标，但练习模式各不相同， 最佳实践不是很好的定义。保留初始肾功能协议的泌尿科管理 （裁判）旨在评估新生儿时期的标准泌尿科协议的结果 到10岁。范德比尔特（MCJCHV）的门罗·卡雷尔儿童医院的脊柱裂计划 每年用脊柱裂来评估大约20名新生儿。 McJCHV的儿科泌尿外科部 已经为这项研究设定了以下目标：1）与我们计划中的每个合格患者接触入学率，2） 为协议指定的诊断研究和干预措施提供纵向数据，3） 评估裁判中的数据以回答有关假设驱动的问题，特别是关于临床预测因素的 敌对的视频动力学和肾功能下降。 PI和临床研究协调员将 确保提交给CDC的数据的质量控制。 PI有生产研究的记录 裁判。这项研究的发表结果将有助于为泌尿外识的最佳实践临床指南提供信息 脊柱裂儿童的管理