Topological Mapping of Immune, Microbiota, Metabolomic and Clinical Phenotypes to Reveal ME/CFS Disease Mechanisms - Admin Core

免疫、微生物群、代谢组学和临床表型的拓扑图揭示 ME/CFS 疾病机制 - Admin Core

• 批准号: 10664153
• 负责人: Derya Unutmaz
• 金额: $ 4.54万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10664153
• 关键词: Acquired Immunodeficiency Syndrome; Administrator; Advocate; Chronic Fatigue Syndrome; Clinical; Collaborations; Communication; Communities; Community Outreach; Congresses; Connecticut; Data; Disease; Education; Education and Outreach; Educational Activities; Ensure; Feedback; Fostering; General Population; Geographic Distribution; Goals; Immune; Immunologist; Leadership; Location; Logistics; Monitor; North Carolina; Occupational activity of managing finances; Office of Administrative Management; Patient Monitoring; Patient Recruitments; Patients; Personnel Management; Physicians; Preparation; Production; Protocols documentation; Publications; Research; Research Activity; Research Personnel; Research Project Grants; Resource Sharing; Resources; Role; Running; Series; Source; Strategic Planning; Technology; Time; United States National Institutes of Health; Universities; Videoconferencing; career development; clinical phenotype; conflict resolution; data management; data sharing; experience; medical schools; meetings; member; metabolomics; microbiota; podcast; programs; virtual; webinar

PROJECT SUMMARY ADMINISTRATIVE CORE The goal of the Administrative (Admin) Core is to provide management, oversight and logistical support for the proposed JAX Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Collaborative Research Center (ME/CFS CRC). The Admin Core's role will be to: 1) foster productive scientific interactions within the JAX ME/CFS CRC, which involves 12 investigators at four different locations (JAX, University of Connecticut, North Carolina State University, Bateman Horne Center); 2) maintain alignment of the JAX ME/CFS CRC with ME/CFS Network activities; 3) monitor the progress of research projects, collaborative projects, and cores towards their specific research and resource-sharing goals; 4) ensure efficient data sharing with the ME/CFS Data Management and Coordinating Center (DMCC); 5) coordinate career development and community outreach activities; and 6) administer the solicitation, review, and selection of Collaborative Project proposals. The Admin Core will be led by Center Director Dr. Derya Unutmaz, a highly accomplished immunologist with experience in Center leadership and a deep connection to the ME/CFS community. Dr. Unutmaz recently formed a clinical alliance withthe Bateman Horne Center of Excellence, the clinical partner on this application, to study ME/CFS. Dr. Unutmaz will leverage this connection with the BHC and with the proposed Community Impact Steering Committee as a source of feedback from key stakeholders as well as an outlet for dissemination of ME/CFS research. The Admin Core will leverage the excellent capabilities, facilities and resources offered at JAX for administering large-scale collaborative research projects and educational activities. These resources include support for a full time, institutionally supported Center Administrator, who will assist Dr. Unutmaz by performing many essential Center functions. Together, Dr. Unutmaz and the Center Administrator will effectively execute the following Specific Aims: 1) Optimize integration and function of JAX ME/CFS CRC activities through strong administrative and scientific oversight, including strategic planning, budgetary oversight, conflict resolution, executive decisions on the direction of research activities and collaborations with other ME/CFS Centers; 2) Enhance communication and collaboration among JAX ME/CFS CRC investigators and between ME/CFS centers and NIH representatives; and 3) Convene Community Impact Steering Committee and engage in education and outreach activities for ME/CFS patients, physicians, and investigators new to ME/CFS research.

项目摘要行政核心 行政（管理）核心的目的是为管理，监督和后勤支持提供 提出的JAX肌电脊髓炎/慢性疲劳综合征协作研究中心 （ME/CFS CRC）。管理员核心的作用将是：1）在JAX内培养生产性科学互动 ME/CFS CRC，涉及四个不同地点的12位调查人员（Jax，康涅狄格大学， 北卡罗来纳州立大学，贝特曼·霍恩中心）； 2）保持JAX ME/CFS CRC的对齐 与我/CFS网络活动一起； 3）监控研究项目，协作项目和 核心其特定的研究和资源分担目标； 4）确保与 ME/CFS数据管理和协调中心（DMCC）； 5）协调职业发展和 社区外展活动； 6）管理协作的招标，审查和选择 项目建议。管理员核心将由中心主任Derya Unutmaz博士领导， 免疫学家在中心领导方面具有经验，并与ME/CFS社区建立了深厚的联系。博士 Unutmaz最近与临床合作伙伴贝特曼·霍恩卓越中心建立了临床联盟 在此应用程序上，研究我/CFS。 Unutmaz博士将利用与BHC以及 拟议的社区影响指导委员会是主要利益相关者的反馈来源以及 传播ME/CFS研究的出口。 管理员核心将 利用出色的功能，设施 以及JAX提供的资源，用于管理大规模的协作研究项目和教育 活动。这些资源包括对全职的支持，机构支持的中心管理员，他们将 通过执行许多基本的中心功能来协助Unutmaz博士。 一起， Unutmaz博士和中心 管理员将有效执行以下特定目的：1）优化JAX的集成和功能 ME/CFS CRC通过强大的行政和科学监督，包括战略规划， 预算监督，解决冲突，有关研究活动方向的执行决策和 与其他ME/CFS中心的合作； 2）加强JAX ME/CFS之间的沟通和协作 CRC调查人员以及我/CFS中心与NIH代表之间； 3）召集社区影响 指导委员会并为我/CFS患者，医师和 我/CFS研究的新研究人员。