Tulane National Primate Research Center

杜兰国家灵长类动物研究中心

• 批准号: 10656656
• 负责人: L Lee HAMM
• 金额: $ 11.83万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10656656
• 关键词: Aging; Animals; Behavior; Biomedical Research; California; Cognition; Communities; Data; Disease model; Epigenetic Process; Genetic; Genomics; Genotype; Goals; Heritability; Human; Human Genome; Immune; Impaired cognition; Individual; Investments; Longevity; Macaca; Macaca mulatta; Methods; Modeling; Molecular; Neurodegenerative Disorders; Oregon; Phenotype; Physiology; Pilot Projects; Primates; Protocols documentation; Recommendation; Reporting; Research; Research Personnel; Resource Sharing; Resources; Rhesus; Scientist; Sequence Read Archive; Single Nucleotide Polymorphism; Somatic Mutation; Source; United States National Institutes of Health; Variant; Work; aged; base; cost; data sharing; genetic variant; genome sequencing; genome wide association study; genomic data; genomic variation; insight; inter-individual variation; interest; member; nonhuman primate; online resource; reproductive; senescence; web portal; whole genome

PROJECT SUMMARY Rhesus macaques are not only the most commonly used nonhuman primate species for biomedical research generally, but also specifically for aging. Rhesus share similar life span metrics with humans and have been used to study numerous facets of aging including cognition, behavior, physiology, and reproductive and immune senescence. Many studies on aging show inter-individual variability with neuro-degenerative disease and cognitive decline perhaps the most obvious. Many of these features of aging are heritable and the variability between individuals is derived, in part, from differences at the genomic level. Any study of aging with a genetic or epigenetic basis will benefit from increased genomic information. While genome-wide association studies (GWAS), particularly on aging phenotypes, are largely impracticable in rhesus macaques, associations of a priori defined genetic variants, such as studies aimed at confirming human GWAS results, may be possible. Moreover, understanding how and where subjects are not genetically different can be as important in identifying sources of variation. Lastly, studies focused on the epigenetics of aging and somatic mutation necessarily rely upon genomic information. It is possible to offer insight into differences between animals by providing whole genome information on animals in the Tulane National Primate Research Center (TNPRC) NIA Aged Rhesus Macaque Colony. This, in turn, would provide researchers using the colony a genomic context in which to ground their studies. It also opens new opportunities for studying molecular aging in nonhuman primate models. At the completion of the proposed project, we will have generated complete whole genome data on the entirety of the NIA-supported colony of aging rhesus macaques at the TNPRC. We will make this information available to the research community in the NIH Short Read Archive (SRA) and at the mGAP web portal. These results will immediately allow any member of the research community with an interest in the NIA-supported aging colony to incorporate genetics into their studies. It will also facilitate pilot studies at the TNPRC to recapitulate and validate previous human studies on aging phenotypes, efforts that can be expanded to other NPRCs with aging colonies.

项目概要 恒河猴不仅是生物医学研究中最常用的非人类灵长类动物 一般而言，但也专门针对老化。恒河猴与人类有着相似的寿命指标，并且已经被 用于研究衰老的许多方面，包括认知、行为、生理、生殖和免疫 衰老。许多关于衰老的研究表明，神经退行性疾病和神经退行性疾病存在个体差异。 认知能力下降也许是最明显的。许多衰老特征都是可遗传的，并且存在变异性 个体之间的差异部分源于基因组水平的差异。任何与遗传有关的衰老研究 或表观遗传基础将受益于增加的基因组信息。虽然全基因组关联研究 （GWAS），特别是关于衰老表型的研究，在恒河猴中很大程度上是不切实际的，先验的关联 确定的遗传变异，例如旨在确认人类 GWAS 结果的研究，是可能的。而且， 了解受试者如何以及在何处没有遗传差异对于识别遗传来源同样重要 变化。最后，关注衰老和体细胞突变的表观遗传学的研究必然依赖于 基因组信息。通过提供全基因组可以深入了解动物之间的差异 杜兰国家灵长类研究中心 (TNPRC) NIA 老年恒河猴的动物信息 殖民地。反过来，这将为使用该菌落的研究人员提供一个基因组背景，使他们能够在其中扎根 研究。它还为研究非人类灵长类动物模型中的分子衰老提供了新的机会。 在拟议项目完成后，我们将生成完整的全基因组数据 NIA 支持的 TNPRC 老年恒河猴群落。我们将提供这些信息 向 NIH Short Read Archive (SRA) 和 mGAP 门户网站的研究社区发送信息。这些结果将 立即允许任何对 NIA 支持的老龄化群体感兴趣的研究界成员 将遗传学纳入他们的研究中。它还将促进 TNPRC 的试点研究，以概括和验证 之前关于衰老表型的人类研究，可以扩展到其他具有衰老群体的 NPRC。