Administrative Core

行政核心

• 批准号: 10699953
• 负责人: Suzanne Walker
• 金额: $ 13.13万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-07 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10699953
• 关键词: Antibiotic Resistance; Area; Biochemistry; Biogenesis; Cell division; Combating Antibiotic Resistant Bacteria; Communication; Communities; Complement; Creativeness; Development; Fostering; Genetic Screening; Goals; Individual; Infection; Infrastructure; Knowledge; Membrane; Membrane Proteins; Multi-Drug Resistance; National Institute of Allergy and Infectious Disease; Pathway interactions; Proteins; Regulation; Research; Research Personnel; Resources; Scientific Advances and Accomplishments; Scientist; Sum; antimicrobial; cell envelope; data sharing; design; enzyme pathway; experience; innovation; member; multidisciplinary; new technology; programs; protein complex; reconstitution; screening; structural biology; therapeutic protein

PROJECT SUMMARY – Administrative Core This Combating Antibiotic Resistant Bacteria (CARB) proposal outlines the design and function of a multidisciplinary, collaborative partnership applying new and innovative approaches to understand the mechanisms underlying bacterial envelope assembly and enable the discovery of treatments against multidrug- resistant infections. Because this is an academic effort, emphasis will be on developing the scientific knowledge that will allow discovery of new compounds and protein therapeutics for especially challenging and unexploited targets involved in cell envelope biogenesis, with membrane proteins and protein complexes a focal point in all three projects. The project team comprises an accomplished group of scientists with extensive and synergistic expertise in biochemistry, including reconstitutions of multi-enzyme pathways and large protein machines, in structural biology of membrane proteins and membrane protein complexes, in approaches for discovery of components essential for cell envelope biogenesis, in the creative use of genetic screens to dissect the regulation of pathways important in cell division and envelope biogenesis, and in development of new technologies and screening approaches for discovery of antimicrobial compounds and therapeutic proteins. Synergistic expertise in both the Gram-negative and Gram-positive cell envelopes is also well-represented among the project team members. The scientific expertise of the project team will be complemented by substantial administrative experience. The goal of the CARB Administrative Core therefore is to oversee the smooth implementation of the research plan and deployment of resources, and to foster the cohesive and well- functioning whole to achieve goals that are greater than the sum of the individual projects. This will be accomplished by achieving the following Specific Aims: 1) Provide program management, oversight, and compliance assurance, 2) Facilitate regular interactions among CARB investigators and trainees from the various labs and projects in a smooth and effective manner, and promote connectivity with other Harvard-wide initiatives; 3) Provide critical infrastructure for fiscal management of the program; 4) Provide a single point of contact and active coordination for on-going communication with NIAID, the Program Officer, and other NIAID staff and initiatives. The Administrative Core will foster the continued development of a highly functioning, well integrated, and synergistic whole to contribute to much-needed scientific advances in a challenging area of research that holds considerable promise for overcoming antibiotic resistance, while generating resources and fostering data sharing with the greater scientific community.

项目摘要 - 行政核心 这种打击抗生素耐药细菌（CARB）提案概述了A的设计和功能 多学科的合作伙伴关系，采用新的和创新的方法来了解 细菌包膜组装的机制，并能够发现针对多药的治疗方法 抗性感染。因为这是一种学术上的努力，所以重点将是发展科学知识 这将允许发现新化合物和蛋白质疗法，以特别具有挑战性和意外 涉及细胞包膜生物发生的靶标，膜蛋白和蛋白质复合物在所有方面都是焦点 三个项目。该项目团队组成了一群成熟的科学家，具有广泛而协同的作用 生物化学方面的专业知识，包括多酶途径和大蛋白机的重构， 膜蛋白和膜蛋白复合物的结构生物学，在发现的方法中 细胞包膜生物发生必不可少的成分，在创造性地使用遗传筛选以剖析 调节在细胞分裂和包膜生物发生中重要的途径以及新的发展 发现抗菌化合物和治疗蛋白的技术和筛选方法。 革兰氏阴性和革兰氏阳性细胞信封的协同专业知识也是代表性的 在项目团队成员中。项目团队的科学专业知识将由 丰富的行政经验。因此，碳水化合物行政核心的目标是监督 平稳地实施研究计划和资源部署，并促进凝聚力和良好的 整体运作以实现大于单个项目的总和。这将是 通过实现以下特定目的来实现：1）提供计划管理，监督和 合规性保证，2）促进碳水化合物调查人员的定期互动和各种培训 实验室和项目以平稳有效的方式，并促进与其他哈佛大学倡议的连通性； 3）为该计划的财政管理提供关键的基础设施； 4）提供一个联系点， 与NIAID，计划官员和其他NIAID员工进行的积极协调，以及 倡议。行政核心将促进一个高度功能，整合， 和协同的整体为在研究的挑战领域中急需的科学进步做出贡献， 在产生资源和培养数据的同时，对克服抗生素抗性有很大的希望 与更大的科学界分享。