High-Definition Characterization of the Persistence and Perturbation of the HIV Reservoir: Project 1

HIV 病毒库的持续性和扰动的高清表征：项目 1

基本信息

批准号：
10654766
负责人：
Jonathan Li
金额：
$ 46.45万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10654766
关键词：
AIDS clinical trial group Address Aftercare Atlases Binding Biological Assay Biological Response Modifiers CD4 Positive T Lymphocytes Cells Clinical Clonal Expansion Clone Cells Communication Dimensions Disease remission Environment Future Genetic Transcription Goals HIV HIV-1 Individual Inflammatory Institution Institutional Review Boards Interruption Intervention Leadership Maps Mediator Membrane Proteins Modeling Participant Pathway interactions Persons Population Progress Reports Proviruses RNA Research Research Personnel Resolution Resources Sampling Services Speed T cell receptor repertoire sequencing T-Lymphocyte Techniques Technology Therapeutic Intervention Transcriptional Activation Viral Viremia Virus Withholding Treatment Work antiretroviral therapy cohort cytokine data exchange design empowerment experience genome-wide insight integration site material transfer agreement meetings multiple omics novel novel therapeutics patient population permissiveness programs protein expression sample collection scientific organization transcriptome viral rebound

项目摘要

SUMMARY The primary goal of this Core is to administer the resources, both financial and participant samples, needed for the successful completion of the Project and Core research aims. Specifically, this core will provide the following services: 1) Provide administrative and budgetary oversight of the Projects and Cores; 2) Plan and arrange for regular team Program leadership meetings and Program scientific meetings; 3) Facilitate the communication and exchange of data between Projects and Cores; 4) Produce and submit annual progress reports, and the final progress report; 5) Assist in the speedy execution of institutional review board applications and material transfer agreements; and 6) Work closely with outside collaborators and the AIDS Clinical Trials Group to coordinate the identification, receipt, and storage of participant samples. In addition, this Core will work closely with outside collaborators and the AIDS Clinical Trials Group to coordinate the identification, receipt, and storage of participant samples. The Administrative and Sample Collection Core will facilitate institutional regulatory approval and material transfer agreements.

概括该核心的主要目标是管理资源，包括财务和参与者样本该项目的成功完成和核心研究的目的。具体来说，该核心将提供以下服务：1）对项目和核心提供行政和预算监督； 2）计划和安排定期的团队计划领导会议和计划科学会议； 3）促进项目和核心之间的数据交流； 4）产生并提交年度进度报告和最终进度报告； 5）协助快速执行机构审查委员会申请和材料转让协议； 6）与外部合作者和艾滋病紧密合作临床试验组以协调参与者样本的识别，收据和存储。此外，该核心将与外部合作者和艾滋病临床试验小组紧密合作，以协调参与者样本的识别，收据和存储。行政和样本收集核心将促进机构监管机构批准和材料转让协议。