Clinical Resource for Alcoholic Hepatitis Inestigation
酒精性肝炎调查的临床资源
基本信息
- 批准号:10652344
- 负责人:
- 金额:$ 68.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-08-01 至 2027-04-30
- 项目状态:未结题
- 来源:
- 关键词:AcuteAcute Alcoholic HepatitisAdrenal Cortex HormonesAlcohol consumptionAlcoholic HepatitisAlcoholic Liver CirrhosisAlcoholic Liver DiseasesAnimal ModelBasic ScienceBiopsyBlood specimenCOVID-19COVID-19 pandemicCaringCell SeparationCellsCholestasisCirrhosisClinicalClinical ResearchCollaborationsCollectionCommunitiesDataData SetDatabasesDevelopmentDiscontinuous CapillaryDiseaseEndothelial CellsEthanolEthanol MetabolismFibrosisFundingGastroenterologyGenerationsGoalsGrantHepatic Stellate CellHepatocellular DamageHepatocyteHepatologyHumanInfiltrationInflammationInstitutionInvestigationJournalsKnowledgeKupffer CellsLaboratoriesLeadLiverLiver diseasesLymphocyteMapsModelingMolecularMouse StrainsNoisePaperParaffinPathogenesisPathologyPatientsPost-Translational Protein ProcessingPreparationPrincipal InvestigatorPrognosisProteomeProteomicsPublicationsPublishingR24ResearchResearch PersonnelResourcesRodentSamplingSerumSpecimenSupportive careTherapeuticTimeTissuesTranslational ResearchUniversitiesalcohol researchcell typedata miningdesignexperimental studyfeedinghuman datahuman tissueinnovationliver inflammationliver injuryliver transplantationmeetingsmortalitynew therapeutic targetnonalcoholic steatohepatitisnovel therapeutic interventionpatient populationprogramssingle-cell RNA sequencingtranscriptometranscriptome sequencingtranscriptomics
项目摘要
Project Summary
Alcoholic hepatitis (AH) is an acute manifestation of alcoholic liver disease (ALD), often with a
grave prognosis. Despite the positive effects of corticosteroid treatment on short-term survival,
this treatment is not ideal and approximately half of patients still die after a short time period. A
major unmet need in the study of acute AH is the lack of a reliable animal model that mimics the
entire spectrum of this disease in humans. Because translational research based on human
samples has a key role in the understanding of mechanisms of alcoholic hepatitis, the collection
of bio specimens from patients with severe AH could help substantially in the design of new
therapeutic strategies. The liver transplant (LT) program for acute AH at Johns Hopkins provided
a unique opportunity for us to create a clinical resource that now serves the alcohol research
community and facilitates access to otherwise unavailable specimens. With support from this
R24 grant, we have created a centralized facility for collecting human samples. The availability of
a large amount of liver tissues and different liver cell types from severe AH patients to the alcohol
research community has generated an innovative resource for translational research of acute AH.
In the last funding period, we have provided our resource to 50 investigators from over 30
institutions/universities resulting in 18 publications in prestigious journals. The goal of this R24
grant renewal is to continue developing clinical resources for severe AH investigations and to
continue meeting investigators’ current and increasing needs and liberally provide our resource
to the entire alcohol research community. Specifically, we need to make more human tissues
(explanted livers from patients with severe AH and other liver diseases) available to any
investigators requesting these. In addition, we will provide expertise at Johns Hopkins to generate
single-cell transcriptome and proteome databases from severe AH that may serve the alcohol
research community and beyond. Specific aims will include maintaining a centralized facility for
collecting human samples from patients with severe AH and other liver diseases and continually
providing our clinical resources to any investigators requesting them, generating single-cell RNA-
sequencing (scRNA-seq) datasets and proteomic and protein post-translational modifications
(PTM) datasets from diseased livers in patients with severe AH or alcoholic cirrhosis (AC) and
making them available to the alcohol research community for data mining/hypothesis generation.
We will continue to promote collaboration through sharing our unique clinical resource.
项目概要
酒精性肝炎(AH)是酒精性肝病(ALD)的急性表现,通常伴有
尽管皮质类固醇治疗对短期生存有积极影响,
这种治疗并不理想,大约一半的患者在短时间内仍然死亡。
急性 AH 研究中主要未满足的需求是缺乏可靠的动物模型来模拟
因为转化研究是基于人类的。
样本对于了解酒精性肝炎的机制、收集样本具有关键作用
来自严重 AH 患者的生物样本可以极大地帮助设计新的
约翰·霍普金斯大学的急性 AH 肝移植 (LT) 计划提供了治疗策略。
对我们来说这是一个独特的机会来创建现在服务于酒精研究的临床资源
社区并促进获取原本无法获得的标本。
R24 拨款,我们创建了一个用于收集人体样本的集中设施。
从严重AH患者到酒精,大量的肝组织和不同的肝细胞类型
研究界为急性 AH 的转化研究提供了创新资源。
在上一个资助期内,我们已向来自 30 多个国家的 50 名研究人员提供了资源
机构/大学在著名期刊上发表了 18 篇论文 R24 的目标。
拨款更新是为了继续为严重的 AH 调查开发临床资源,并
继续满足调查人员当前和不断增长的需求,并慷慨地提供我们的资源
具体来说,我们需要制造更多的人体组织。
(来自患有严重 AH 和其他肝脏疾病的患者的移植肝脏)可供任何人使用
此外,我们将在约翰·霍普金斯大学提供专业知识来生成这些信息。
来自严重 AH 的单细胞转录组和蛋白质组数据库可能与酒精有关
研究界及其他领域的具体目标将包括维护一个集中设施。
从患有严重 AH 和其他肝病的患者身上收集人体样本,并不断
向任何有需求的研究人员提供我们的临床资源,生成单细胞 RNA-
测序 (scRNA-seq) 数据集以及蛋白质组和蛋白质翻译后修饰
(PTM) 严重 AH 或酒精性肝硬化 (AC) 患者患病肝脏的数据集
使它们可供酒精研究界进行数据挖掘/假设生成。
我们将继续通过分享我们独特的临床资源来促进合作。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('ZHAOLI SUN', 18)}}的其他基金
Clinical, Radiologic and Biochemical Factors Related to Diabetes Development after Acute Pancreatitis
急性胰腺炎后与糖尿病发展相关的临床、放射学和生化因素
- 批准号:
10264897 - 财政年份:2020
- 资助金额:
$ 68.59万 - 项目类别:
Project 4-Animal transplant models to characterize immune and regenerative effects of alcohol
项目4-动物移植模型来表征酒精的免疫和再生作用
- 批准号:
10560563 - 财政年份:2019
- 资助金额:
$ 68.59万 - 项目类别:
Project 4-Animal transplant models to characterize immune and regenerative effects of alcohol
项目4-动物移植模型来表征酒精的免疫和再生作用
- 批准号:
10093989 - 财政年份:2019
- 资助金额:
$ 68.59万 - 项目类别:
Project 4-Animal transplant models to characterize immune and regenerative effects of alcohol
项目4-动物移植模型来表征酒精的免疫和再生作用
- 批准号:
10356017 - 财政年份:2019
- 资助金额:
$ 68.59万 - 项目类别:
Clinical Resources for Alcoholic Hepatitis Investigations
酒精性肝炎研究的临床资源
- 批准号:
9982730 - 财政年份:2016
- 资助金额:
$ 68.59万 - 项目类别:
Clinical Resources for Alcoholic Hepatitis Investigations
酒精性肝炎研究的临床资源
- 批准号:
9321291 - 财政年份:2016
- 资助金额:
$ 68.59万 - 项目类别:
Clinical Resources for Alcoholic Hepatitis Investigations
酒精性肝炎研究的临床资源
- 批准号:
9754728 - 财政年份:2016
- 资助金额:
$ 68.59万 - 项目类别:
Clinical Resource for Alcoholic Hepatitis Inestigation
酒精性肝炎调查的临床资源
- 批准号:
10411102 - 财政年份:2016
- 资助金额:
$ 68.59万 - 项目类别:
Clinical Resources for Alcoholic Hepatitis Investigations
酒精性肝炎研究的临床资源
- 批准号:
10461673 - 财政年份:2016
- 资助金额:
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Alcoholic Liver Diseases: Damage, Repair and Stem Cell Regeneration
酒精性肝病:损伤、修复和干细胞再生
- 批准号:
7990196 - 财政年份:2010
- 资助金额:
$ 68.59万 - 项目类别:
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