Imaging Core

成像核心

• 批准号: 10652566
• 负责人: Richard E. Carson
• 金额: $ 51.96万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10652566
• 关键词: Adverse effects; Blood; Blood specimen; Brain imaging; Calibration; Clinical; Clinical Data; Data; Data Analyses; Data Storage and Retrieval; Dedications; Development; Devices; Drug Addiction; Environment; Equipment; Generations; Goals; Human; Image; Image Analysis; Imaging Device; Infrastructure; Institutional Review Boards; Kinetics; Laboratories; Methodology; Methods; Mission; Molecular; Monitor; Multi-Institutional Clinical Trial; Participant; Patients; Pennsylvania; Physics; Pilot Projects; Positron-Emission Tomography; Procedures; Protocols documentation; Radiation; Radiochemistry; Reporting; Research; Research Design; Research Personnel; Resolution; Resources; Safety; Scheme; Services; Time; Tracer; Universities; Work; addiction; archive data; data archive; data exchange; design; dosimetry; experience; image archival system; image reconstruction; imaging agent; imaging capabilities; imaging facilities; imaging modality; imaging study; instrumentation; novel; opioid use disorder; parametric imaging; protocol development; radiotracer

IMAGING CORE The Penn PET Addiction Center of Excellence (PACE) Imaging Core will support the design, implementation, execution, and analysis of the PET imaging components of the Center's pilot projects. The Imaging Core will function as a resource for expertise and guidance for investigators and will also serve as a functioning platform to provide services for P30 investigators that include imaging study design, imaging study execution including imaging-related patient coordination, image analysis, PET image data archiving, and regulatory support. As such, the Imaging Core will work closely with the other Cores and the PIs of the P30 Core Center's pilot projects to support the Center's mission in drug addiction research and to expand the scope of PET imaging for research on opiate use disorders at Penn and Yale University. Specific aims of the Imaging Core include: 1) to design the PET components of the Penn PACE pilot core projects; 2) to coordinate and execute PET imaging studies proposed in the Pilot Core at Penn and at Yale; 3) to guide and execute PET image analyses, including kinetic analysis and novel image analysis approaches; and (4) to guide and support regulatory submissions and provide oversight of imaging studies by working closely with the other Cores on data and safety monitoring for the PET imaging component of Pilot Core projects. The Imaging Core is co-led by Dr. David Mankoff of Penn and Dr. Richard Carson of the Yale University PET Center. The Imaging Core takes advantage of a highly developed infrastructure for human PET imaging research at both the Penn and the Yale University PET Centers. The core also benefits from synergistic expertise at Penn (multi-center clinical trials, protocol development, regulatory infrastructure) and Yale (molecular brain imaging methodology, tracer kinetic analysis). The Core has a unusual depth of combined depth of expertise in PET instrumentation physics, image generation, and data analysis – along with dedicated unique scanner resources- to support the scientific mission of this P30 Center.

成像核心 宾夕法尼亚州 PET 成瘾卓越中心 (PACE) 成像核心将支持设计、实施、 该中心的成像核心项目的 PET 成像组件的执行和分析。 作为调查人员的专业知识和指导资源，也将作为一个运作平台 为 P30 研究人员提供影像研究设计、影像研究执行等服务，包括 与成像相关的患者协调、图像分析、PET 图像数据存档和监管支持。 因此，成像核心将与 P30 核心中心试点的其他核心和 PI 密切合作 支持该中心药物成瘾研究使命并扩大 PET 成像范围的项目 宾夕法尼亚大学和耶鲁大学成像核心的具体目标包括： 1) 设计 Penn PACE 试点核心项目的 PET 组成部分 2) 协调和执行 PET； 宾夕法尼亚大学和耶鲁大学的 Pilot Core 中提出的成像研究；3) 指导和执行 PET 图像分析， 包括动力学分析和新颖的图像分析方法；(4) 指导和支持监管 通过与其他核心在数据和 Pilot Core 项目的 PET 成像部分的安全监测由 Dr. 宾夕法尼亚大学的 David Mankoff 和耶鲁大学 PET 中心的 Richard Carson 博士采用了成像核心技术。 宾夕法尼亚大学和耶鲁大学高度发达的人类 PET 成像研究基础设施的优势 大学 PET 中心还受益于宾夕法尼亚大学的协同专业知识（多中心临床试验、 协议开发、监管基础设施）和耶鲁大学（分子脑成像方法、示踪动力学 核心在 PET 仪器物理方面拥有不同寻常的综合专业知识， 图像生成和数据分析 - 以及专用的独特扫描仪资源 - 以支持科学 这个 P30 中心的使命。