IGNITE KUH NRSA Training Core

IGNITE KUH NRSA 培训核心

• 批准号: 10652651
• 负责人: DIDIER PORTILLA
• 金额: $ 38.52万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10652651
• 关键词: Acute Renal Failure with Renal Papillary Necrosis; Address; Adult; Advocacy; Affect; American; Anti-Inflammatory Agents; Area; Attenuated; Basic Science; Benign; Bioenergetics; Biology; Biomechanics; Biomedical Engineering; Blood; Breeding; Career Choice; Childhood; Chronic Kidney Insufficiency; Cisplatin; Clinical Research; Clinical Sciences; Clinical and Translational Science Awards; Cohort Studies; Communication; Cystoscopy; Data Science; Dendritic Cells; Development; Disease; Doctor of Philosophy; Endothelium; FGF2 gene; Faculty; Future; General Population; Goals; HL-60 Cells; Health; Healthcare Systems; Hematological Disease; Hematology; Historically Black Colleges and Universities; Human; Immunity; Individual; Inflammation; Infrastructure; Injury; Institution; Interferon Type II; Kidney; Kidney Diseases; Lead; Lipids; Mediating; Medical; Methods; Microbubbles; Mitochondria; Mole the mammal; National Research Service Awards; Nephrology; Nephrons; Neuroimmune; Operative Surgical Procedures; Pathway interactions; Patients; Physicians; Postdoctoral Fellow; Predictive Analytics; Price; Race; Recovery; Reperfusion Injury; Research; Research Institute; Research Personnel; Research Priority; Research Training; Resistance; Resuscitation; Risk Factors; Role; Scientist; Selection for Treatments; Societies; Sphingolipids; Sphingosine; Sphingosine-1-Phosphate Receptor; Students; Surgeon; System; Systems Biology; Therapeutic; Training; Training Programs; Training and Education; Translational Research; Ultrasonics; Underrepresented Populations; Underrepresented Students; United States; Universities; Urologic Diseases; Urology; Virginia; Washington; chemotherapy; cholinergic; clinical center; diabetic; doctoral student; drug discovery; functional genomics; human disease; innovation; kidney fibrosis; medical specialties; nanoparticle delivery; nanotherapeutic; next generation; non-diabetic; novel; pressure; prevent; programs; receptor; recruit; renal ischemia; rosin; sphingosine 1-phosphate; sphingosine kinase; success; targeted delivery; telecare; translational health science; trend; ultrasound; workforce needs

Contact PD/PI: Okusa, Mark D. NRSA-Training-001 (883) NRSA TRAINING CORE ABSTRACT The Integrated Virginia Research Training Centers in Kidney, Urology and Hematology (IGNITE KUH) training program is being proposed to address an unmet need and major gap in prioritized research training through development and integration of a statewide research program in the Commonwealth of Virginia. The IGNITE KUH NRSA Training Core is an innovative and distinctive multi-institutional, multi-departmental program comprising a team of 65 outstanding faculty from the University of Virginia (UVA), Virginia Commonwealth University (VCU), and Virginia Polytechnic Institute and State University (VT) with primary research programs anchored in the basic research and clinical science of benign KUH diseases in six thematic areas: Systems Biology and Functional Genomics, Immunity and Inflammation, Biomedical Engineering, Nanotherapeutics and Drug Discovery, Clinical and Data Sciences, and Predictive Analytics. The NRSA Training Core leverages existing strengths in kidney and hematological disease research, uniting them with urological disease research in a cohesive, integrated and coordinated research training program. The NRSA Training Core will be enhanced through participation and integration of the Translational Health Research Institute of Virginia (iTHRIV), a component of the Clinical and Translational Science Award (CTSA) partnership between UVA and VT, and the Wright Center for Clinical and Translational Research (CCTR) at VCU. Three major goals of the IGNITE KUH NRSA Training Core include: 1) increase training of PhD students, residents (urology) and postdoctoral fellows in basic and translational aspects of KUH in health and disease using a unified approach; 2) establish an integrated Virginia-wide research training program focused on KUH-diseases; and 3) attract outstanding students and postdoctoral fellows with long-term career interests in basic or clinical research into the IGNITE KUH Training Program. IGNITE KUH will prioritize strategies to attract students from underrepresented populations at several partner institutions, including three historically black universities in Virginia – Virginia State University (VSU), Hampton University (HU), and Virginia Union Universities (VUU) – thereby further enhancing development and training of both PhD researchers and physician scientists. The IGNITE KUH NRSA Training Core will address human health issues through increased education and training of the next generation of researchers and physician scientists in basic research or clinical science who can guide and lead future research programs aiming to lessen human disease and suffering in KUH-specific fields. Project Summary/Abstract Page 322 Contact PD/PI: Okusa, Mark D. NRSA-Training-001 (883) References 1. Jager KJ, Kovesdy C, Langham R, Rosenberg M, Jha V, Zoccali C. A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases. Kidney Int 2019;96:1048-50. 2. Stapleton FB, Andreoli S, Ettenger R, Kamil E, Sedman A, Chesney R. Future workforce needs for pediatric nephrology: an analysis of the nephrology workforce and training requirements by the Workforce Committee of the American Society of Pediatric Nephrology. J Am Soc Nephrol 1997;8:S5-8. 3. Rosner MH, Berns JS. Transforming Nephrology. Clin J Am Soc Nephrol 2018;13:331-4. 4. de Boer IH. Nephrology at a Crossroads. Clin J Am Soc Nephrol 2018;13:324. 5. Lane CA, Brown MA. Nephrology: a specialty in need of resuscitation? Kidney Int 2009;76:594-6. 6. Tonelli M, Wiebe N, Manns BJ, et al. Comparison of the Complexity of Patients Seen by Different Medical Subspecialists in a Universal Health Care System. JAMA Netw Open 2018;1:e184852. 7. McKibben MJ, Kirby EW, Langston J, et al. Projecting the Urology Workforce Over the Next 20 Years. Urology 2016;98:21-6. 8. Washington SL, 3rd, Baradaran N, Gaither TW, et al. Racial distribution of urology workforce in United States in comparison to general population. Transl Androl Urol 2018;7:526-34. 9. Woldu SL, Raj GV. Surgery: The surgeon-scientist - a dying breed? Nat Rev Urol 2016;13:698-9. 10. Keswani SG, Moles CM, Morowitz M, et al. The Future of Basic Science in Academic Surgery: Identifying Barriers to Success for Surgeon-scientists. Ann Surg 2017;265:1053-9. 11. Hougen HY, Lobo JM, Corey T, et al. Optimizing and validating the technical infrastructure of a novel tele- cystoscopy system. J Telemed Telecare 2016;22:397-404. 12. Sharma D, Wallace N, Levinsohn EA, et al. Trends and factors affecting the US adult hematology workforce: a mixed methods study. Blood Adv 2019;3:3550-61. 13. Hoots WK, Abkowitz JL, Coller BS, DiMichele DM. Planning for the future workforce in hematology research. Blood 2015;125:2745-52. 14. Soffer E, Hoots WK. Challenges facing the benign hematology physician-scientist workforce: identifying issues of recruitment and retention. Blood Adv 2018;2:308. 15. Perry HM, Huang L, Ye H, et al. Endothelial Sphingosine 1Phosphate Receptor1 Mediates Protection and Recovery from Acute Kidney Injury. J Am Soc Nephrol 2016;27:3383-93. 16. Bajwa A, Huang L, Kurmaeva E, et al. Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN-gamma. J Am Soc Nephrol 2016;28:1145-61. 17. Bajwa A, Rosin DL, Chroscicki P, et al. Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury. J Am Soc Nephrol 2014. 18. Bajwa A, Huang L, Ye H, et al. Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury. J Immunol 2012;189:2584-96. 19. Bajwa A, Jo SK, Ye H, et al. Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. J Am Soc Nephrol 2010;21:955-65. 20. Jo SK, Bajwa A, Ye H, et al. Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury. Kidney Int 2009;75:167-75. 21. Jo SK, Bajwa A, Awad AS, Lynch KR, Okusa MD. Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease. Kidney Int 2008;73:1220-30. 22. Kao LP, Morad SAF, Davis TS, et al. Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells. J Lipid Res 2019;60:1590-602. 23. Gigliotti JC, Huang L, Ye H, et al. Ultrasound prevents renal ischemia-reperfusion injury by stimulating the splenic cholinergic anti-inflammatory pathway. J Am Soc Nephrol 2013;24:1451-60. 24. Tanaka S, Inoue T, Hossack JA, Okusa MD. Nonpharmacological, Biomechanical Approaches to Control Inflammation in Acute Kidney Injury. Nephron 2017;137:277-81. 25. Gigliotti JC, Huang L, Bajwa A, et al. Ultrasound Modulates the Splenic Neuroimmune Axis in Attenuating AKI. J Am Soc Nephrol 2015;26:2407-81. 26. Chappell JC, Song J, Burke CW, Klibanov AL, Price RJ. Targeted delivery of nanoparticles bearing fibroblast growth factor-2 by ultrasonic microbubble destruction for therapeutic arteriogenesis. Small 2008;4:1769-77. 27. Anderson AH, Xie D, Wang X, et al. Novel Risk Factors for Progression of Diabetic and Nondiabetic CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis 2020. References Cited Page 323

联系 PD/PI：Okusa, Mark D.NRSA-Training-001 (883) NRSA 培训核心摘要 弗吉尼亚肾脏、泌尿科和血液学综合研究培训中心 (IGNITE KUH）正在提出培训计划，以解决未满足的需求和优先考虑的重大差距 通过开发和整合联邦研究计划进行研究培训 弗吉尼亚州 IGNITE KUH NRSA 培训核心是一项创新且独特的培训。 多机构、多部门项目，由来自 65 名优秀教师组成的团队组成 弗吉尼亚大学 (UVA)、弗吉尼亚联邦大学 (VCU) 和弗吉尼亚大学 理工学院和州立大学 (VT)，主要研究项目设在 良性 KUH 疾病的基础研究和临床科学六个主题领域： 系统 生物学与功能基因组学、免疫与炎症、生物医学工程、 纳米治疗和药物发现、临床和数据科学以及预测分析。 NRSA 培训核心利用肾脏和血液疾病研究方面的现有优势， 将它们与泌尿系统疾病研究结合起来，进行有凝聚力、综合和协调的研究 NRSA 培训核心将通过参与和整合得到加强。 弗吉尼亚转化健康研究所 (iTHRIV) 的成员，该研究所是临床研究的组成部分 UVA 和 VT 以及 Wright 之间的合作关系和转化科学奖 (CTSA) VCU 临床和转化研究中心 (CCTR) 的三个主要目标。 KUH NRSA 培训核心包括：1) 增加对博士生、住院医师（泌尿科）和 KUH 在健康和疾病方面的基础和转化方面的博士后研究员使用 2）建立一个统一的弗吉尼亚范围内的研究培训计划，重点关注 KUH-疾病；3）吸引具有长期职业生涯的优秀学生和博士后研究员 对 IGNITE KUH 培训计划的基础或临床研究感兴趣。 在多个合作伙伴中优先考虑吸引弱势群体学生的战略 机构，包括弗吉尼亚州三所历史悠久的黑人大学——弗吉尼亚州立大学 (VSU)、汉普顿大学 (HU) 和弗吉尼亚联合大学 (VUU) – 从而进一步 加强博士研究人员和医师科学家的发展和培训。 IGNITE KUH NRSA 培训核心将通过加强教育解决人类健康问题 并培训下一代研究人员和医学科学家进行基础研究或 临床科学谁可以指导和领导未来的研究项目，旨在减少人类 KUH 特定领域的疾病和痛苦。 项目摘要/摘要第 322 页 联系 PD/PI：Okusa, Mark D.NRSA-Training-001 (883) 参考 1. Jager KJ、Kovesdy C、Langham R、Rosenberg M、Jha V、Zoccali C。用于宣传和宣传的单一号码 全球有超过 8.5 亿人患有肾脏疾病。 2019；96：1048-50。 2. Stapleton FB、Andreoli S、Ettenger R、Kamil E、Sedman A、Chesney R。儿科未来的劳动力需求 肾病学：对肾病学劳动力和劳动力培训要求的分析 美国儿科肾病学会委员会。J Am Soc Nephrol 1997；8：S5-8。 3.Rosner MH，Berns JS。《肾病学临床杂志》2018 年；13：331-4。 4. de Boer IH。十字路口的肾脏病学杂志 2018 年；13：324。 5. Lane CA，Brown MA。肾脏病学：需要复苏的专业吗？2009 年；76：594-6。 6. Tonelli M、Wiebe N、Manns BJ 等人不同医疗机构所见患者复杂性的比较 全民医疗保健系统的亚专家。JAMA Netw Open 2018；1：e184852。 7. McKibben MJ、Kirby EW、Langston J 等人预测未来 20 年的泌尿科劳动力。 泌尿外科 2016 年；98：21-6。 8. Washington SL, 3rd, Baradaran N, Gaither TW, et al. 美国泌尿科劳动力的种族分布 各州与一般人群的比较。 Transl Androl Urol 2018；7:526-34。 9. Woldu SL，Raj GV。外科：外科医生科学家 - 垂死的品种？ Nat Rev Urol 2016；13：698-9。 10. Keswani SG、Moles CM、Morowitz M 等人《学术外科基础科学的未来：识别》 外科医生科学家的成功障碍，Ann Surg 2017；265：1053-9。 11. Hougen HY、Lobo JM、Corey T 等人优化和验证新型远程通信的技术基础设施。 膀胱镜检查系统。J Telemed Telecare 2016；22：397-404。 12. Sharma D、Wallace N、Levinsohn EA 等人影响美国成人血液学的趋势和因素。 劳动力：混合方法研究 2019；3：3550-61。 13. Hoots WK、Abkowitz JL、Coller BS、DiMichele DM 血液学未来劳动力规划。 研究。2015 年；125：2745-52。 14. Soffer E，Hoots WK。良性血液学医师科学家队伍面临的挑战：识别 招募和保留问题。2018 年；2：308。 15. Perry HM、Huang L、Ye H 等人。内皮鞘氨醇 1 磷酸盐受体 1 介导保护和 急性肾损伤的恢复。J Am Soc Nephrol 2016；27：3383-93。 16. Bajwa A、Huang L、Kurmaeva E 等人：鞘氨醇激酶 2 缺乏可通过以下途径减轻肾脏纤维化： IFN-γ。J Am Soc Nephrol 2016；28：1145-61。 17. Bajwa A、Rosin DL、Chroscicki P 等人。1-磷酸鞘氨醇受体 1 增强线粒体 功能并减少顺铂引起的肾小管损伤。J Am Soc Nephrol 2014。 18. Bajwa A, Huang L, Ye H, et al. 树突状细胞鞘氨醇 1-磷酸受体 3 调节 Th1-Th2 肾缺血再灌注损伤中的极性。JImmunol 2012；189：2584-96。 19. Bajwa A，Jo SK，Ye H，等人近曲小管中鞘氨醇 1-磷酸 1 受体的激活 防止缺血再灌注损伤。 J Am Soc Nephrol 2010；21：955-65。 20. Jo SK、Bajwa A、Ye H 等人。鞘氨醇激酶在肾脏缺血再灌注损伤中的不同作用。 肾脏国际 2009；75：167-75。 21. Jo SK、Bajwa A、Awad AS、Lynch KR、Okusa MD 1-磷酸鞘氨醇受体：生物学和 肾脏疾病的治疗潜力。Kidney Int 2008；73：1220-30。 22. Kao LP, Morad SAF, Davis TS, et al. 化疗选择压力改变鞘脂成分和 耐药 HL-60 细胞中的线粒体生物能学。 J Lipid Res 2019；60：1590-602。 23. Gigliotti JC，Huang L，Ye H，等人超声通过刺激肾缺血再灌注损伤 脾胆碱能抗炎途径。J Am Soc Nephrol 2013；24：1451-60。 24. Tanaka S、Inoue T、Hossack JA、Okusa MD。 急性肾损伤中的炎症 2017；137：277-81。 25. Gigliotti JC、Huang L、Bajwa A 等人。 AKI。《肾病学会杂志》2015 年；26：2407-81。 26. Chappell JC、Song J、Burke CW、Klibanov AL、Price RJ 纳米颗粒的靶向递送。 成纤维细胞生长因子-2 通过超声波微泡破坏来治疗小动脉生成。 2008；4：1769-77。 27. Anderson AH、Xie D、Wang X 等人。糖尿病和非糖尿病 CKD 进展的新风险因素： 慢性肾功能不全队列 (CRIC) 研究结果 2020 年。 引用的参考文献第 323 页