A versatile lens architecture to shape visible light

用于塑造可见光的多功能镜头架构

• 批准号: 10652885
• 负责人: DONALD K ROPER
• 金额: $ 42.92万
• 依托单位: UTAH STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10652885
• 关键词: Age; Alzheimer' s Disease; Architecture; Area; Automobile Driving; Aviation; Biomedical Research; Classification; Collaborations; Color; Color Perception; Color Visions; Contact Lenses; Cornea; Cues; Custom; Deposition; Depth Perception; Deterioration; Devices; Disadvantaged; Disease; Dyes; Electron Microscopy; Elements; Emotions; Engineering; Environment; Evaluation; Exhibits; Eye; Fishes; Future; Geometry; Glaucoma; Health; Individual; Inherited; Injections; Lead; Light; Macular degeneration; Measurement; Mentors; Methods; Military Personnel; Minor; Molds; Mormyridae; Motion Perception; Nature; Optics; Outcome; Parkinson Disease; Perception; Performance; Persons; Pharmaceutical Preparations; Preparation; Procedures; Publications; Quality of life; Red-Green Color Blindness; Research; Retina; Severities; Shapes; Side; Specific qualifier value; Spectrum Analysis; Surface; Testing; Variant; Visible Radiation; Vision Disorders; Work; career; design; design,build,test; fabrication; food preparation; improved; lens; manufacture; monocular; nanometer; nanoparticle; notch protein; novel; outcome disparities; polydimethylsiloxane; recruit; retinal rods; self assembly; simulation; submicron; transmission process; undergraduate student

PROJECT SUMMARY This proposal aims to demonstrate a versatile lens architecture to shape light incident on the cornea in order to remedy deuteranomaly, with potential for other vision disorders. Twelve million people in the U.S. are deficient in their ability to discern color differences. This negatively impacts their quality of life for health, emotions, and especially careers. They often have difficulty preparing food, driving, or taking medications. They may be disadvantaged or restricted from certain work in military, aviation, or engineering. While typically inherited, color vision deficiency (CVD) frequently accompanies glaucoma, macular degeneration, Alzheimer’s disease, Parkinson’s disease, and other diseases. Color vision deteriorates markedly with age. There are wide variations in classification of CVD and its severity. So, outcomes from accommodation by standard tinted lenses vary considerably. Many such lenses are bandpass filters. They reduce light incident on the retina across a broad spectral region on either side of the anomaly. This distorts the wearer’s perception of contrast, hue, and intensity. Benefits of monocular bandpass filters are offset by alterations in depth and motion perception. In contrast, an ideal notch filter eliminates transmission across just tens of nanometers (nm) of visible light. This separates peak sensitivities of red and green photopigments which overlap excessively in deuteranomaly. Attempts, however, to make notch filters from dye- or nanoparticle-doped lenses still produce broad reductions in transmission around the target wavelength. This wavelength is approximately 560 nm for red-green color blindness. So, doped filters alter perceived hue, saturation, and brightness relative to normal. Nature offers clues to high-acuity, red-green color vision in the eyes of the elephantnose fish (Gnathonemus petersii). Multilayers of submicron-sized crystal lamellae reflect incident light away from rod photoreceptors. Reflection is wavelength- specific due to submicron spacing between adjacent lamellae. We hypothesize that submicron-spaced optical nodes at the convex surface of a lens can be customized to sharply reduce transmission at a wavelength near 560 nanometers Doing so could improve red-green perception based on the anomaloscopic examination of each person. This proposal would use the PI’s rapid bridging simulations to identify composition, geometry, and spatial arrangement of optical nodes required to improve color perception based on chromaticity. Specified nodes would be synthesized and self-assembled into a template stamped with regularly-spaced cavities with few missing nodes. This uses a method recently demonstrated by the PI. This protolens would be located at the convex surface of a contact lens to integrate into existing contact lens manufacture. Microspectroscopy of the lens-integrated protolens would quantify improvement in color perception. This AREA proposal will recruit 8 diverse undergraduates to collaborate with experts in devices, optoelectronics, simulation, and soft materials to conduct biomedical research that strengthens the research environment at USU and prepares them to lead independent research in future eye health through mentoring, publication, and proposal preparation.

项目摘要 该建议旨在展示一种多功能的镜头体系结构，以塑造角膜上的光线事件，以记住 氘化，具有其他视力障碍。美国有10000万人缺乏他们的能力 辨别颜色差异。这对他们的健康，情感，尤其是职业的生活质量产生了负面影响。他们 通常很难准备食物，驾驶或服用药物。他们可能处于不利地位或限制 在军事，航空或工程中工作。虽然通常继承，但色觉缺乏症（CVD）经常涉及 青光眼，黄斑变性，阿尔茨海默氏病，帕金森氏病和其他疾病。彩色视觉恶化 随着年龄的增长明显。 CVD的分类及其严重性有很大差异。因此，标准有色的住宿结果 镜头谨慎不同。许多这样的镜头都是带通滤波器。它们减少了视网膜上的光线事件 异常两侧的光谱区域。这会扭曲佩戴者对对比，色调和强度的看法。好处 单眼带通滤波器的深度和运动感知的改变所抵消。相比之下，理想的缺口过滤器 消除仅跨几十纳米（NM）的可见光的传播。这将红色和 绿色的绿色光成像在氘化中极为重叠。但是，尝试从染料或 纳米粒子透镜仍会在目标波长周围的传播中大大减少。这个波长是 大约560 nm，用于红绿色色盲。因此，掺杂的过滤器改变了感知的色调，饱和度和亮度相对 正常。 大自然为象豆鱼（Gnathonemus petersii）眼中的高激素，红绿色的色觉提供了线索。 亚微米大小的晶体薄片的多层反映远离杆感光体的入射光。反射是 波长 - 特定于相邻薄片之间的亚微米间距。我们假设亚微米间隔光学 可以定制镜头凸表面的节点，以在560纳米附近的波长下急剧减少传播 这样做可以根据每个人的隔离检查来改善红绿色的感知。该提议将 使用PI的快速桥接模拟来识别所需光节点的组成，几何和空间排列 基于色度提高颜色感知。指定的节点将被合成并自组装成一个 模板上用规则间隔的腔体盖章，几乎缺少节点。这使用了最近通过的方法 pi。该植物将位于隐形眼镜的凸表面，以集成到现有的隐形眼镜制造中。 晶状体积分质子的微光谱学可以量化颜色感知的改善。 该领域建议将招募8位潜水员的本科生与设备，光电子学的专家合作， 模拟和软材料进行生物医学研究，以增强USU的研究环境并准备 他们通过心理，出版和提案准备来领导未来眼睛健康的独立研究。