The Use of Virtual Reality to Discover Objective Correlates of Alcohol Craving

使用虚拟现实来发现酒精渴望的客观关联

• 批准号: 10652931
• 负责人: Kelly Elizabeth Courtney
• 金额: $ 18.76万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10652931
• 关键词: Adult; Alcohol consumption; Alcoholic beverage heavy drinker; Alcohols; Attention; Awareness; Basic Science; Biological Markers; Blinking; Clinical; Clinical Sciences; Clinical Trials; Cognitive; Conscious; Corpus striatum structure; Cues; Development; Dopamine; Environment; Exhibits; Foundations; Future; Goals; Guidelines; Intervention; Investigation; Laboratories; Maintenance; Measurement; Measures; Methods; National Institute on Alcohol Abuse and Alcoholism; Nature; Participant; Pathogenesis; Patient Self-Report; Pharmaceutical Preparations; Pharmacological Treatment; Phenotype; Process; Psychophysiology; Reporting; Research; Sampling; Science; Technology; Telephone; Testing; Time; Treatment outcome; Validation; Visual; addiction; alcohol abuse therapy; alcohol craving; alcohol cue; alcohol exposure; attentional bias; clinically relevant; craving; cue reactivity; effective therapy; experience; feasibility testing; follow-up; improved; innovation; interest; novel; psychobiologic; psychologic; response; smartphone based assessment; substance use; therapy development; virtual reality; virtual reality environment; visual tracking

PROJECT SUMMARY The study of craving for alcohol and drugs is increasingly thought to be essential for understanding the pathogenesis and maintenance of addiction. However, valid and reliable methods for investigating this psychobiologic phenomenon are lacking. This study seeks to develop a novel, ecologically valid paradigm that capitalizes on the technological advances and realism of virtual reality (VR) to both induce alcohol craving, via presentation of realistic alcohol-related cues, and reliably assess alcohol craving, via measurement of potential craving correlates (attentional bias and spontaneous eye-blink rate [EBR]) and subjective reports. Following initial acceptability testing and optimization (n=15), three alcohol active and three neutral VR scenes will be administered to a sample comprised of low-moderate alcohol drinkers (n=50) and heavy alcohol drinkers (n=50). Eye-tracking (to establish attentional bias towards alcohol cues) and EBR will be continuously recorded during presentation of the scenes. Participants will then be followed for seven-days, via mobile assessment, and contacted by phone at day 30, to obtain self-report responses of subjective alcohol craving and alcohol use in their naturalistic environment. Thus, the specific aims of the proposed research are: (1) to develop an ecologically valid and immersive VR cue-reactivity paradigm that reliably induces alcohol craving, (2) test the feasibility, reliability, and utility of VR derived attentional bias as an objective craving correlate by comparing it against commonly used measures of subjective craving and attentional bias, and (3) examine the predictive utility of the objective correlates of alcohol craving acquired during the paradigm and subjective reports of alcohol craving and alcohol use during follow-up. The use of EBR as an objective craving correlate will also be investigated as an exploratory aim. Once fully developed and tested, this paradigm will have tremendous applications within basic science research on alcohol craving and within clinical science via providing a new platform to develop interventions that aim to reduce craving. Further, this project will advance our understanding of attentional bias and its utility as a predictive measure of alcohol craving and use.

项目摘要 人们越来越认为对酒精和药物的渴望研究对于理解 成瘾的发病机理和维持。但是，对此进行有效且可靠的方法 缺乏心理生物学现象。这项研究旨在开发一种新颖的生态有效范式， 利用虚拟现实的技术进步和现实主义（VR）既诱使酒精的渴望 通过测量潜力来呈现与逼真的酒精相关线索，并可靠地评估酒精的渴望 渴望与（注意偏见和自发的眼睛闪烁率[EBR]）和主观报告相关。下列的 最初的可接受性测试和优化（n = 15），将三个酒精和三个中性VR场景为 由低压饮酒者（n = 50）和大量酒精饮用者组成的样品管理 （n = 50）。眼睛跟踪（建立对酒精提示的注意力偏见），EBR将不断记录 在场景演示期间。然后，参与者将通过移动评估进行七日遵守， 并在第30天通过电话联系，以获得主观酒精和酒精的自我报告回应 在其自然环境中使用。 因此，拟议的研究的具体目的是：（1）开发生态有效和身临其境 可靠地诱导酒精的VR提示反应范式，（2）测试可行性，可靠性和效用 VR通过将注意力偏置与普遍使用的措施进行比较，将注意力偏差作为目标偏见相关 主观渴望和注意力偏见，（3）检查客观相关的预测效用 在范式中获得的酒精渴望以及在 后续。将EBR用作客观渴望相关的使用也将作为探索目的进行研究。 一旦完全开发和测试，该范式将在基础科学中具有巨大的应用 通过提供一个新的平台来开发干预措施，对酒精渴望和临床科学的研究 旨在减少渴望。此外，该项目将提高我们对注意力偏见及其效用的理解 作为酒精渴望和使用的预测度量。