Molecular Basis of Viral Infectivity

病毒感染性的分子基础

• 批准号: 10415068
• 负责人: DAVID M. KNIPE
• 金额: $ 48.44万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-07-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10415068
• 关键词: Molecular; Viral

Project Abstract This training program in mechanisms of viral infection will train 6 predoctoral students and 4 postdoctoral fellows per year. The goal of this training grant is to provide students who 1) are well trained in the study of mechanisms of viral replication, 2) can investigate human viruses causing disease, such as the human immunodeficiency virus and herpes viruses, 3) can investigate new antiviral compounds and vaccines to prevent or treat viral diseases, 4) can study viruses that are emerging threats to human health, and 5) can use viruses to probe the cellular and molecular biology of prokaryotic and eukaryotic cells. Nearly all of the predoctoral applicants will have an undergraduate education in biology or chemistry. All of the predoctoral trainees will be graduate students in the Program in Virology, an inter-faculty degree-granting program. The laboratories of the training faculty are located at Harvard Medical School and affiliated hospitals, Harvard School of Public Health, Dana-Farber Cancer Institute, Children's Hospital, and the Harvard University Fairchild Laboratory in Cambridge. The Program in Virology students pursue a broad biological program of study with courses in virology, molecular biology and genetics, biochemistry, cell biology and immunology. These students will also attend seminars, research meetings, and perform 3 laboratory rotations. Faculty curriculum advisors will provide guidance for the students throughout their training, and they will choose their advisors from the Program in Virology faculty. Students will take a preliminary qualifying examination during their second year, and within 6 months form a dissertation advisory committee to provide advice on the progress of their research. Upon successful completion and defense of the dissertation, the student will be awarded a Ph.D. degree in virology. Postdoctoral training takes place in the laboratories of the training faculty. Consistent with the specialized nature of postdoctoral training, the primary program will be designed by the faculty advisor. This training program is designed to augment that training by engaging the postdoctoral fellow in virology program retreats, courses, and seminars. Postdoctoral trainees will form a postdoctoral advisory committee that will meet at least annually to evaluate research and career paths. Predoctoral and postdoctoral trainees will participate in a training program in the ethical conduct of science. An active and previously successful program by the training faculty and Division of Medical Sciences is described for the recruitment of underrepresented minority trainees.

项目摘要 病毒感染机制的该培训计划将培训6名术前学生和4个博士后 每年的研究员。这项培训补助金的目的是为学生提供1）在研究中接受良好培训的学生 病毒复制机制，2）可以调查引起疾病的人类病毒，例如人类 免疫缺陷病毒和疱疹病毒，3）可以研究新的抗病毒化合物和疫苗 预防或治疗病毒疾病，4）可以研究正在出现对人类健康威胁的病毒，5）可以使用 探测原核生物和真核细胞的细胞和分子生物学的病毒。几乎所有 申请申请人将接受生物学或化学的本科教育。全部 受训者将成为该计划的研究生，该计划是一项教师跨学士学位课程。这 培训学院的实验室位于哈佛医学院和哈佛大学附属医院 达纳 - 法伯癌症研究所，儿童医院和哈佛大学公共卫生学院 剑桥的Fairchild实验室。病毒学学生的计划探讨了广泛的生物学计划 通过病毒学，分子生物学和遗传学，生物化学，细胞生物学和免疫学的课程研究。 这些学生还将参加研讨会，研究会议，并进行3次实验室轮换。学院 课程顾问将在整个培训中为学生提供指导，他们将选择他们的 病毒学教师计划的顾问。学生将参加初步的合格考试 他们的第二年，在6个月内成立了一个论文咨询委员会，以提供有关 他们的研究进展。成功完成和辩护论文后，学生将是 授予博士学位病毒学学位。博士后培训发生在培训学院的实验室。 与博士后培训的专业性质一致，主要程序将由 教师顾问。该培训计划旨在通过参与博士后研究员来增强该培训 在病毒学计划撤退，课程和研讨会上。博士后学员将形成博士后咨询 委员会至少每年开会以评估研究和职业道路。杂物和博士后 学员将参加一项科学道德行为的培训计划。主动和以前 介绍了培训教师和医学科学系的成功计划，以招募 代表性不足的少数民族学员。