Administrative Core

行政核心

基本信息

批准号：
10631990
负责人：
JOHN N. CONSTANTINO
金额：
$ 14.72万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-28 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10631990
关键词：
Adult Area Attention Behavioral Biological Models Brain Child Care Clinical Collaborations Core Facility Development Developmental Disabilities Diagnosis Disparate Down Syndrome Education Ensure Environment Etiology Evolution Extramural Activities Faculty Funding Future Genetic Genome Human Individual Infrastructure Institution Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Interruption Investments Knowledge Laboratories Leadership Mental Health Microcephaly Mission Missouri Modeling National Institute of Child Health and Human Development Neurodevelopmental Disability Neurology Pathogenicity Pediatrics Phase Phenotype Postdoctoral Fellow Prevention Productivity Provider Psychiatry Research Research Personnel Research Training Resources Role Science Series Structure System Time Training Programs Translations United States National Institutes of Health Universities Washington Zika Virus brain abnormalities clinical translation cohesion cost effective design disability frontier functional genomics improved member neuroimaging operation personalized medicine post-doctoral training premature prevent programs research facility standard of care translational pipeline

项目摘要

Administrative Core Project Abstract In this application we present a core scientific structure that is specifically designed to support scientific effort along the overarching themes of prematurity prevention and advancing personalized medicine approaches to IDD; for the latter, utilizing expertise in the elucidation of intermediate phenotypes, advancing characterization of the developing human brain, and infrastructures for functional genomic studies. The Administrative Core assumes responsibility for scientific oversight as an integrated Center that is a discovery pipeline for translational advances in IDD research. The Specific Aims are: 1) To sustain an effective system of management of the day- to-day operation of the Center’s funds and resources, which includes the efficient flow of necessary resources to maintain three efficient, cost-effective, state-of-the-art core scientific facilities that constitute a critical infrastructure for IDD research in the WUSTL environment: the Model Systems Core (MSC), the Developmental Neuroimaging Core (DNC), and the Clinical-Translational Core (CTC); 2) To stimulate intramural and extramural scientific collaboration and discovery along key frontiers of IDD research and 3) To disseminate new knowledge and implement practice improvements that are based upon new discovery, through partnerships with the University Centers of Excellence in Developmental Disabilities (UCEDDs), Leadership Education in Neurodevelopmental Disabilities (LENDs), the Missouri Dept. of Mental Health, regional clinical providers, and other external entities involved in the care of children and adults with developmental disabilities.

行政核心项目摘要在此应用中，我们提出了一种核心科学结构，该结构专门设计用于支持科学工作沿着预防早产的总体主题，并推进个性化医学方法 idd;对于后来，在阐明中间表型中使用专业知识，推进表征发展的人脑和功能基因组研究的基础设施。行政核心负责科学监督为综合中心，这是转化的发现管道 IDD研究的进步。具体目的是：1）维持一天的有效管理系统 - 该中心资金和资源的今天运营，其中包括必要资源的有效流保持三个高效，具有成本效益的最先进的核心科学设施，构成关键 WUSTL环境中IDD研究的基础架构：模型系统核心（MSC），发展神经影像学核心（DNC）和临床翻译核心（CTC）； 2）刺激壁内和壁外沿IDD研究的主要边界和3）传播新知识的科学合作与发现并通过与新发现，实施实践改进大学发育障碍卓越中心（UCEDDS），领导力教育神经发育残疾（贷款），密苏里州心理健康部，区域临床提供者和其他外部实体参与了患有发育障碍儿童和成人的护理。