Examining Neurophysiological Predictors of Treatment Response to a Multi-Component Early Intervention for Socially Inhibited Preschoolers

检查社交抑制学龄前儿童对多成分早期干预治疗反应的神经生理学预测因素

• 批准号: 10391565
• 负责人: Nicholas J Wagner
• 金额: $ 8.82万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2023-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10391565
• 关键词: Aftercare; Anxiety; Anxiety Disorders; Arousal; Attention; Attenuated; Behavior; Behavior Therapy; Behavioral inhibition; Biological; Characteristics; Child; Child Rearing; Data; Data Set; Development; Distress; Early Intervention; Foundations; Funding; Future; Galvanic Skin Response; Grant; Intervention; Link; Measures; Mediating; National Institute of Mental Health; Nervous System Physiology; Nursery Schools; Parasympathetic Nervous System; Parent-Child Relations; Parents; Patients; Physiology; Play; Prediction of Response to Therapy; Preparation; Prevention approach; Process; Public Health; Randomized Controlled Trials; Regulation; Reporting; Research; Research Domain Criteria; Resources; Risk; Role; Science; Sinus Arrhythmia; Social Anxiety Disorder; Strategic Planning; Stress; Structure; Sympathetic Nervous System; System; Testing; Time; Turtles; Tweens; aged; behavior change; behavioral response; cognitive system; early childhood; experience; indexing; innovation; insight; intervention program; neurophysiology; parental influence; parental role; personalized intervention; personalized medicine; programs; psychoeducational; relating to nervous system; respiratory; response; skills training; social; social interventions; social skills; social stress; social stressor; treatment group; treatment response

PROJECT SUMMARY/ABSTRACT The apparent and impactful role played by parents’ intrusive-controlling (IC) parenting behaviors in the stability of children’s behavioral inhibition (BI) and as a moderator of risk for anxiety disorders (AD) has motivated treatment and prevention approaches that specifically target these behaviors. Parents who are easily aroused and have difficulty regulating in response to their child’s distress are prone to ineffective, harsh, and intrusive parenting, and a growing body of research demonstrates that parents’ physiology influences their behaviors, particularly during times of heightened stress. However, very little research has investigated the influences of parents’ neurophysiological reactivity and regulation on IC behaviors. Moreover, although there is growing evi- dence that neurophysiological functioning may predict behavior change in response to intervention, no re- search has examined this possibility with regard to IC parenting or children’s BI. The current proposal leverag- es an existing randomized controlled trial dataset (n = 151 parent-child dyads) to (Aim 1) establish the influ- ences of parents’ neurophysiological regulation on their IC parenting behaviors and whether these links are moderated by parents’ anxiety and (Aim 2) test the influences of parents’ neurophysiological regulation and IC parenting on reductions in child BI across treatment, whether children’s neurophysiological regulation mediates these associations, and the moderating role of parents’ anxiety. The Turtle Program (TP), a multi-component (i.e., combination of Parent-Child Interaction Therapy and children’s Social Skills Training) early intervention program, was developed to target IC parenting to reduce risk for anxiety among preschool-aged children by comparing it to the best available psychoeducational treatment for BI, Cool Little Kids (R01MH103253; PIs: Rubin and Chronis-Tuscano).The current proposal specifically examines parents’ sympathetic nervous system (SNS) and parents’ and children’s parasympathetic nervous system (PNS) functioning assessed across social stressors, an impactful next step given PNS and SNS functioning index neural structures implicated in arousal and attention regulation (RDoC Arousal and Cognitive Systems) and may inform treatment response. TP and CLK, which have both demonstrated reductions in IC parenting, systematically vary in intensity, structure, and required resources. As such, the current proposal will provide preliminary evidence for who might need more intensive treatments which will promote the development of personalized intervention and reduce patient bur- den. Additionally, this proposal is innovative and significant because it will (1) establish the processes and mechanisms through which parents’ and children’s neurophysiological regulation predicts treatment response, (2) clarify who might benefit from more intensive treatments, and (3) provide preliminary insight into potential treatment targets.

项目摘要/摘要 父母在稳定中的侵入性控制（IC）育儿行为所扮演的明显而有影响力的角色 儿童的行为抑制（BI）和作为焦虑症风险的主持人（AD）已经成熟 专门针对这些行为的治疗和预防方法。容易引起的父母 并且很难响应孩子的痛苦而进行调节 育儿和越来越多的研究表明，父母的生理学会影响他们的行为， 特别是在压力增加的时候。但是，很少研究研究的影响 父母对IC行为的神经生理反应性和调节。而且，尽管越来越多 DNCE认为神经生理功能可能会预测响应干预的行为变化，无需 搜索已经检查了有关IC育儿或儿童BI的这种可能性。当前的提案杠杆 ES现有的随机对照试验数据集（n = 151个亲子二元组）（目标1）建立影响 - 父母对其IC育儿行为的神经生理调节的经典以及这些联系是否是 由父母的动画和（目标2）测试父母神经生理调节和IC的影响 育儿儿童BI在整个治疗中的减少，儿童的神经生理调节培养基是否 这些关联以及父母动画的调节作用。乌龟计划（TP），多组分 （即，亲子互动疗法和儿童社交技能培训的结合）早期干预 计划的计划是针对IC育儿的，以降低学龄前儿童中动画的风险 将其与BI，酷小孩的最佳可用心理教育治疗（R01MH103253; PIS： 鲁宾和成年人）。当前的提案专门研究父母的交感神经系统 （SNS）以及在社会上评估的父母和孩子的副交感神经系统（PNS） 压力源是PNS和SNS功能索引神经结构的有影响力的下一步 以及注意力调节（RDOC唤醒和认知系统），并可能为治疗反应提供信息。 TP和 CLK既表现出IC育儿的减少，在强度，结构和 需要资源。因此，当前的提案将为谁可能需要更多的人提供初步证据 强化治疗将促进个性化干预措施的发展并减少患者的侵害 书房。此外，该提案具有创新性和重要意义，因为它将（1）建立流程和 父母和孩子的神经生理调节预测治疗反应的机制， （2）Clariify谁可能会从更深入的治疗中受益，（3）提供对潜在潜力的初步见解 治疗目标。

项目成果

Psychometric Properties, Factor Structure, and Validity of the Sensitivity to Threat and Affiliative Reward Scale in Children and Adults.

• DOI: 10.1177/10731911221128946
• 发表时间: 2023-09
• 期刊: ASSESSMENT
• 影响因子: 3.8
• 作者: Perlstein, Samantha;Wagner, Nicholas;Dominguez-Alvarez, Beatriz;Antonio Gomez-Fraguela, Jose;Romero, Estrella;Lopez-Romero, Laura;Waller, Rebecca
• 通讯作者: Waller, Rebecca

Characterizing change in vagal tone during the first three years of life: A systematic review and empirical examination across two longitudinal samples.

• DOI: 10.1016/j.neubiorev.2021.07.025
• 发表时间: 2021-10
• 期刊: Neuroscience and biobehavioral reviews
• 影响因子: 8.2
• 作者: Wagner NJ;Holochwost SJ;Lynch SF;Mills-Koonce R;Propper C
• 通讯作者: Propper C

Comparison of behaviorally inhibited and typically developing children's play behaviors in the preschool classroom.

• DOI: 10.3389/fpsyg.2023.1193915
• 发表时间: 2023
• 期刊: FRONTIERS IN PSYCHOLOGY
• 影响因子: 3.8
• 作者: Druskin, Lindsay R.;Novick, Danielle R.;Smith, Kelly A.;Chronis-Tuscano, Andrea;Wagner, Nicholas J.;Pham, Stephanie;Fleece, Hailey M.;Danko, Christina M.;Rubin, Kenneth H.
• 通讯作者: Rubin, Kenneth H.

Examining Links Between Infant Parasympathetic Regulation during the Still-Face Paradigm and Later Callous-Unemotional Traits.

检查静止面孔范式中婴儿副交感神经调节与后来的冷酷无情特征之间的联系。

• DOI: 10.1007/s10802-021-00860-7
• 发表时间: 2022
• 期刊: Research on child and adolescent psychopathology
• 影响因子: 2.5
• 作者: Lynch,SarahF;Bedford,Rachael;Propper,Cathi;Wagner,NicholasJ
• 通讯作者: Wagner,NicholasJ

Examining the Relations Between Children's Vagal Flexibility Across Social Stressor Tasks and Parent- and Clinician-Rated Anxiety Using Baseline Data from an Early Intervention for Inhibited Preschoolers.

使用来自抑制性学龄前儿童早期干预的基线数据，检查儿童在社会压力源任务中的迷走神经灵活性与家长和临床医生评定的焦虑之间的关系。

• DOI: 10.1007/s10802-023-01050-3
• 发表时间: 2023
• 期刊: Research on child and adolescent psychopathology
• 影响因子: 2.5
• 作者: Wagner,NicholasJ;Shakiba,Nila;Bui,HongNT;Sem,Kathy;Novick,DanielleR;Danko,ChristinaM;Dougherty,LeaR;Chronis-Tuscano,Andrea;Rubin,KennethH
• 通讯作者: Rubin,KennethH